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  4. Human Trefoil factor 2(TFF2) ELISA kit

Human Trefoil factor 2(TFF2) ELISA kit

  • 中文名稱：
    人三葉因子2(TFF2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL023432HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人三葉因子2(TFF2)酶聯免疫試劑盒（CSB-EL023432HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、組織培養上清液樣本中的TFF2含量。TFF2即三葉因子2，它是一種具有三葉結構的小分子蛋白，在胃腸道黏膜保護與修復等方面起著重要作用。研究機制上，主要聚焦于它如何促進細胞遷移、增殖，抵抗凋亡，調節黏液合成與分泌，以維持胃腸道黏膜的完整性和穩定性。試劑盒檢測范圍為31.25 ng/mL-2000 ng/mL，靈敏度為7.81 ng/mL。本試劑盒適用于基礎醫學研究中TFF2的生物學功能探索，包括黏膜修復機制、炎癥調控及腫瘤微環境研究，可配合多種樣本類型靈活應用：血清/血漿用于評估循環系統中TFF2的動態變化，組織勻漿適用于組織局部表達量分析，而細胞培養上清則為體外實驗模型提供便捷檢測方案。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    SML 1 ELISA Kit; SML1 ELISA Kit; SP ELISA Kit; Spasmolysin ELISA Kit; Spasmolytic polypeptide ELISA Kit; spasmolytic protein 1 ELISA Kit; TFF 2 ELISA Kit; TFF2 ELISA Kit; TFF2_HUMAN ELISA Kit; trefoil factor 2 (spasmolytic protein 1) ELISA Kit; Trefoil factor 2 ELISA Kit; Trefoil factor 2 precursor ELISA Kit
  • 縮寫：
    TFF2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell culture supernates
  • 檢測范圍：
    31.25 ng/mL-2000 ng/mL
  • 靈敏度：
    7.81 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TFF2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %87
    Range %80-92
    1:2Average %95
    Range %90-100
    1:4Average %97
    Range %90-103
    1:8Average %92
    Range %88-97
  • 回收率：
    The recovery of human TFF2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-98
    EDTA plasma (n=4)9890-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    20002.026 2.007 2.017 1.920
    10001.364 1.306 1.335 1.238
    5000.788 0.724 0.756 0.659
    2500.457 0.427 0.442 0.345
    1250.262 0.246 0.254 0.157
    62.50.175 0.167 0.171 0.074
    31.250.119 0.114 0.117 0.020
    00.101 0.093 0.097 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
  • 基因功能參考文獻：
    1. Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD. PMID: 28355260
    2. this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4. PMID: 27523981
    3. Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6. [Review] PMID: 26201258
    4. We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer PMID: 25899003
    5. protease-activated receptor 4 and Trefoil factor 2 are expressed in human colorectal cancer PMID: 25876034
    6. The structural features of the N-linked N,N'-di-N-acetyllactosediamine-inducing determinant on human TFF2 are discussed. PMID: 25210040
    7. Human TTF2 is a lectin that binds alpha-GlcNAc-capped mucin 6 g with antibiotic activity against Helicobacter pylori. PMID: 25124036
    8. Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome. PMID: 23628371
    9. There is an association between TFF2 and TFF3 polymorphisms and risk of atrophic gastritis and gastric cancer in Chinese people. PMID: 23933418
    10. Human gastric TFF2 peptide contains an N-linked fucosylated N,N'-diacetyllactosediamine (LacdiNAc) oligosaccharide PMID: 22997242
    11. Report TFF2 expression in normal/diseased pancreas and suggest role in tumor cell migration. PMID: 22286382
    12. Report a novel TFF2 splice variant (EX2TFF2) which correlates with longer overall survival time in cholangiocarcinoma. PMID: 22159958
    13. TFF2 messenger RNA expression is significantly increased in nasal mucosal brushings during asthma exacerbations in children. PMID: 22329990
    14. Data show that frog TFF2 activates protease-activated receptor (PAR) 1 to induce human platelet aggregation, and suggest that human TFF2 promotes cell migration via PAR4. PMID: 21461878
    15. TFF2 is mitogenic in cholangiocarcinoma via EGFR/MAPK activation. PMID: 21472131
    16. TFF2 negatively regulates preneoplastic progression and subsequent tumor development in the stomach, a role that is subverted by promoter methylation during H pylori infection PMID: 20801119
    17. autoinduction of promoter requires an upstream cis-acting element PMID: 12054609
    18. Transcripts not detectable in conjunctiva. Review. PMID: 12613926
    19. expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa PMID: 12717829
    20. The results suggest that TFF2 expression may play a role in gastric cancer invasion and could be a useful target for therapeutic intervention. PMID: 13679442
    21. PPARgamma mediates NSAIDs-induced up-regulation of TFF2 expression in gastric epithelial cells. PMID: 14759512
    22. TFF2 and its putative receptor, DMBT1, were expressed non-specifically in biliary epithelial cells of the damaged small bile ducts, suggesting a cytoprotective role in biliary pathophysiology. PMID: 15101998
    23. TFF2 could play a role in mammary gland tumorigenesis. PMID: 15177880
    24. TFF2 is expressed in normal and malignant breast epithelial cells and it stimulates the migration of breast cancer cells. PMID: 15177883
    25. Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades PMID: 15256384
    26. Demonstration that TFF2 rhythm is impaired in cohorts of individuals known to suffer gastric symptoms suggests that interventions to restore the normal TFF2 rhythm in those with poor mucosal protection could reduce morbidity. PMID: 15984970
    27. TFF2 staining was detected in large, diffuse tumors and in tumors with lymph node metastasis and had a significant correlation with the number of microvessels. PMID: 16166422
    28. human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm PMID: 16359755
    29. Co-localization of TFF2 with gland mucous cell mucin suggests a physical interaction between TFF2 and gland mucous cell mucin. The TFF2 trapped in the adherent mucins may be responsible for mucosal defense, healing, and repair. PMID: 16786324
    30. PPARgamma may be involved in the gastric mucosal defense through regulating TFF2 expression PMID: 17118693
    31. Gastrin regulates TFF2 transcription through a GC-rich DNA-binding site and a protein kinase dependent pathway. PMID: 17332476
    32. CXCR4 as a bona fide signaling receptor for TFF2 and suggest a mechanism through which TFF2 may modulate immune and tumorigenic responses in vivo. PMID: 19064997
    33. The researchers found evidence that H. pylori-associated CAG has a negative effect on the expression of TFF2 in the gastric antrum and may be associated with H. pylori-induced gastric mucosal damage. PMID: 19344006
    34. p53 induces cell apoptosis and inhibits cell migration in part by downregulating TFF2 expression through an AP-1-like site, suggesting that TFF2 may be an important downstream target of p53. PMID: 19541923

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Stomach.
  • 數據庫鏈接：

    HGNC: 11756

    OMIM: 182590

    KEGG: hsa:7032

    STRING: 9606.ENSP00000291526

    UniGene: Hs.2979



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