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  4. Human Thiamin pyrophosphokinase 1(TPK1) ELISA kit

Human Thiamin pyrophosphokinase 1(TPK1) ELISA kit

  • 中文名稱：
    人硫胺焦磷酸激酶1(TPK1)酶聯免疫試劑盒
  • 貨號：
    CSB-EL024103HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人硫胺焦磷酸激酶1(TPK1)酶聯免疫試劑盒（CSB-EL024103HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的TPK1含量。人硫胺焦磷酸激酶1（TPK1）是一種催化硫胺素轉化為焦磷酸硫胺素的酶，參與糖酵解和能量代謝。研究顯示，TPK1基因突變可導致硫胺素代謝功能障礙綜合征5（TMDS5），影響TPP生成，引發多種神經發育和運動障礙。通過基因檢測和NGS技術，可確定TPK1基因變異情況，為疾病診斷和治療提供依據。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于探究TPK1在神經系統疾病、代謝紊亂及硫胺素缺乏相關病理機制中的表達變化，為研究硫胺素代謝調控、評估營養干預效果或探索相關疾病的分子機制提供可靠的科研工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    hTPK1 ELISA Kit; Placental protein 20 ELISA Kit; PP20 ELISA Kit; Thiamin pyrophosphokinase 1 ELISA Kit; Thiamine diphosphokinase ELISA Kit; Thiamine kinase ELISA Kit; Thiamine pyrophosphokinase 1 ELISA Kit; THMD5 ELISA Kit; TPK1 ELISA Kit; TPK1_HUMAN ELISA Kit
  • 縮寫：
    TPK1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.8 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TPK1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %86-95
    1:2Average %102
    Range %97-107
    1:4Average %91
    Range %85-97
    1:8Average %97
    Range %91-103
  • 回收率：
    The recovery of human TPK1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9790-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.329 2.368 2.349 2.243
    10001.876 1.857 1.867 1.761
    5001.339 1.368 1.354 1.248
    2500.843 0.839 0.841 0.735
    1250.566 0.599 0.583 0.477
    62.50.411 0.423 0.417 0.311
    31.250.250 0.259 0.255 0.149
    00.105 0.107 0.106
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
  • 基因功能參考文獻：
    1. Mutation analysis of TPK1 uncovered three missense, one splice-site, and one frameshift mutation resulting in decreased TPK protein levels PMID: 22152682
    2. findings indicate the importance of the Sp1 transcription factor cis-element in regulating the human thiamin pyrophosphokinase gene (hTPK1) gene expression PMID: 16262001
    3. Genomic variations in either the fetal or maternal TPK1 gene could contribute to variability of birth weight in normal humans. PMID: 17295612
    4. This is the first report on the primary sequence for mammalian thiamin pyrophosphokinase, a protein that catalyzes the pyrophosphorylation of thiamin with adenosine 5'-triphosphate to form thiamin pyrophosphate. PMID: 10567383
  • 相關疾病：
    Thiamine metabolism dysfunction syndrome 5, episodic encephalopathy type (THMD5)
  • 蛋白家族：
    Thiamine pyrophosphokinase family
  • 組織特異性：
    Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues.
  • 數據庫鏈接：

    HGNC: 17358

    OMIM: 606370

    KEGG: hsa:27010

    STRING: 9606.ENSP00000353165

    UniGene: Hs.660232



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