在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit

  • 中文名稱:
    人可溶性CD38(sCD38)酶聯免疫試劑盒
  • 貨號:
    CSB-E09884h
  • 規格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人可溶性CD38(sCD38)酶聯免疫試劑盒(CSB-E09884h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的CD38含量。CD38是一種跨膜糖蛋白,廣泛表達于多種免疫細胞。其在調節細胞黏附、遷移、信號轉導等方面有重要作用。研究機制上,它可作為靶點被單克隆抗體等藥物靶向結合,阻斷相關信號通路,以發揮抗腫瘤、調節免疫等潛在治療功效 。試劑盒檢測范圍為0.9 ng/mL-60 ng/mL,適用于基礎科研中sCD38表達水平的動態監測、疾病模型機制研究以及生物標志物篩選等應用場景;支持科研人員高效開展免疫學、腫瘤學及細胞生物學領域的定量分析工作。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD antigen CD38
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍:
    0.9 ng/mL-60 ng/mL
  • 靈敏度:
    0.225 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human sCD38 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
     SampleSerum(n=4)
    1:5Average %95
    Range %90-100
    1:10Average %96
    Range %92-101
    1:20Average %94
    Range %88-99
    1:40Average %93
    Range %86-100
  • 回收率:
    The recovery of human sCD38 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8982-96
    EDTA plasma (n=4)9287-96
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    602.272 2.372 2.322 2.155
    301.779 1.859 1.819 1.652
    151.209 1.229 1.219 1.052
    7.50.7240.7400.732 0.565
    3.750.429 0.439 0.434 0.267
    1.870.3390.3470.343 0.176
    0.90.235 0.239 0.237 0.070
    00.166 0.168 0.167  
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
  • 基因功能參考文獻:
    1. CD38 and cADPR are key players in the orches- tration of cellular responses to respiratory syncytial virus by infected monocyte-derived dendritic cells. PMID: 29178427
    2. our data are consistent with the conclusion that CD38 plays a role in murine and human lung tumorigenesis PMID: 29228209
    3. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma PMID: 28249894
    4. Empathic response mediates the CD38-altruism association. PMID: 28865941
    5. Increased levels of HLADR and CD38 expressions in peripheral blood were associated with oral lesions in HIV-positive patients. Periodontal disease was associated with HLADR expression. PMID: 28500735
    6. Panobinostat increased CD38 expression in a dose-dependent manner in primary myeloma cells. This was specific for myeloma cells and did not occur in lymphoma cell lines. This increase enabled the antimyeloma activity of daratumumab. PMID: 28476749
    7. To demonstrate the therapeutic effect of daratumumab in CLL, we generated a disseminated CLL mouse model with the CD38(+) MEC2 cell line and CLL patient-derived xenografts (CLL-PDX). Daratumumab significantly prolonged overall survival of MEC2 mice, completely eliminated cells from the infiltrated organs, and significantly reduced disease burden in the spleen of CLL-PDX PMID: 27637890
    8. CD38 mRNA levels were correlated with lower Autism Quotient (AQ), indicating enhanced social skills. CD38 expression and CD157 eQTL SNPs altogether account for a substantial 14% of the variance in sociality. the ecological validity of these findings was demonstrated with subjects with higher PBL CD38 expression having more friends, especially for males. PMID: 28212520
    9. CD38(lo) luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor kappaB (NF-kappaB) signaling. In response to oncogenic transformation, CD38(lo) luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay PMID: 27926864
    10. Results provide evidence that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions. PMID: 28544069
    11. these data demonstrate an important role for CD38 and complement-inhibitory protein expression levels in daratumumab sensitivity. PMID: 27307294
    12. Results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling. PMID: 27064238
    13. The data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring. PMID: 26306999
    14. Primary human melanoma cell lines suppress in vitro T cell proliferation through an adenosinergic pathway in which CD38 and CD73 play a prominent role. PMID: 26329660
    15. CD38 and its related genes are highly expressed in human nasopharyngeal carcinoma cell lines. PMID: 25630761
    16. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm. PMID: 26407101
    17. the expression of CD38+ on both CD4+, CD8+T lymphocytes from peripheral blood and CSF discriminated between viremic and non-viremic patients PMID: 26365593
    18. study points to an association between maternal SNPs in the CD38 in Japanese women and susceptibility to preterm birth. PMID: 26025338
    19. Peripheral blood CD38 bright CD8+ effector memory T cells predict acute graft-versus-host disease. PMID: 25881755
    20. CD38 is expressed on human MDSC-like cell population that is expanded in the peripheral blood of advanced-stage cancer patients. PMID: 26294209
    21. Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab. PMID: 25975191
    22. Genetic variation in CD38 and breastfeeding experience interact to impact infants' attention to social eye cues. PMID: 26371313
    23. genetic polymorphism is associated with diffuse large B-cell lymphoma susceptibility in Egyptians PMID: 25564959
    24. Hairy-cell leukemia patients that were CD38-positive had a shorter mean time to salvage therapy than CD38-negative ones. CD38 expression in HCL drives poor prognosis by promoting survival and heterotypic adhesion. PMID: 26170397
    25. alterations in content of soluble molecules CD38 are associated with characteristics of tumor process that indicates at their monitoring significance under malignant neoplasms of uterus PMID: 26470437
    26. The results indicate that the net charge of the N-terminal segment is important in determining the membrane topology of CD38 and that the type III orientation can be a functional form of CD38 for Ca(2)-signaling. PMID: 25447548
    27. The majority of extranodal NK/T cell lymphoma cases were CD38 positive, which significantly correlated with poor outcomes. PMID: 25865943
    28. High levels of CD38 reduced intracellular (NAD+) levels and blocked acquired resistance by inhibiting the activity of the NAD+-dependent SIRT1 deacetylase PMID: 24967705
    29. CD38 status was associated with behavior and psychological reactions within live interactions, as well as global relationship quality PMID: 24396004
    30. These results validate CD38 as a therapeutic target and support the current evaluation of this unique CD38-targeting functional antibody in phase I clinical trials in patients with CD38+ B-cell malignancies. PMID: 24987056
    31. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo PMID: 25310288
    32. CD38 expression is regulated by micro-RNA 708 in airway smooth muscle cells. PMID: 25175907
    33. CD38 has a role in chronic lymphocytic leukemia growth and trafficking PMID: 24990614
    34. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism. PMID: 25505279
    35. Increased numbers of circulating ICOS(+) and IL-21(+) Tfh and CD38(+) plasma cells may be exhibited by patients with recent diagnoses of primary biliary cirrhosis. PMID: 25404409
    36. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
    37. Autism and features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
    38. results demonstrate that CD38(+) cells are a useful model to study effects of the cellular NAD levels on cellular processes and establish a new linker between cellular NAD levels and oxidative stress PMID: 24295520
    39. only one SNP in CD38 was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness, but not a continuous measure of social connectedness or the continuously married outcome. PMID: 24209975
    40. Data suggest that the uniquely increased expression of CD38 and E2F2 in rheumatoid arthritis (RA) synovial tissues contribute to the immunoactivation of the disease. PMID: 24397353
    41. PBMC from MM patients display a deregulated response related to CD38 activation pathway defects; CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis PMID: 24489445
    42. These data suggest that both functional roles of CD38 might be important in the pathogenesis of B-CLL. PMID: 24216102
    43. Atorvastatin and rosiglitazone did not affect the expression of CD38. PMID: 23686733
    44. Data suggest CD38 (CD38 antigen (p45) protein) and CD49d (alpha4 Integrin; very late antigen-4 alpha) are more than just markers of an aggressive chronic lymphocytic leukemia (CLL) cell type and play functional roles in pathobiology of CLL. [REVIEW] PMID: 24288111
    45. CD38 is expressed within caveolae and its function is linked to the caveolar regulatory proteins. PMID: 24275509
    46. Report diagnosis of multiple myeloma using two-color flow cytometry based on kappa/lambda ratios of CD38-gated plasma cells. PMID: 23755763
    47. CD38-cADPR mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+) signaling. PMID: 23940051
    48. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM. PMID: 23729443
    49. Data show that ADP-ribosylation of CtBP1-S/BARS by brefeldin A (BFA) occurs via synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. PMID: 23716697
    50. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. PMID: 22955446

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    ADP-ribosyl cyclase family
  • 組織特異性:
    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
  • 數據庫鏈接:

    HGNC: 1667

    OMIM: 107270

    KEGG: hsa:952

    STRING: 9606.ENSP00000226279

    UniGene: Hs.479214



主站蜘蛛池模板: 玩超薄丝袜人妻的经历| 伊伊人成亚洲综合人网| 国内少妇偷人精品视频| 大地资源在线观看官网第三页| 女人下边被添全过视频的网址| 中文字幕亚洲色妞精品天堂| 一本大道久久东京热av| 国产成人午夜在线视频a站| 国产欧美精品区一区二区三区| 东京热一区二区三区无码视频| 欧美毛多水多黑寡妇| 欧美成 人版中文字幕| 午夜爽爽爽男女免费观看麻豆国产| 中文字幕资源网| 精品国产乱码久久久久久1区2区 | 国产美女视频免费观看网址| 国产色a在线观看| 天天拍天天看天天做| 精品蜜臀av在线天堂| 亚洲成av 人片在线观看无码 | 国产精品久久久久无码av色戒| 欧美国产日韩a在线视频| 亚洲制服有码在线丝袜| 717影院理论午夜伦八戒| 亚洲亚洲人成综合网络| 亚洲国产成人va在线观看天堂| 纯肉无遮挡无码日本动漫| 亚洲欧美中文日韩v在线97| 无码成a毛片免费| 日本免费人成视频播放| 一区二区三区鲁丝不卡麻豆| 午夜dj在线观看高清在线视频完整版 | 熟妇与小伙子matur老熟妇e| 欧美z0zo人禽交欧美人禽交 | 人妻少妇邻居少妇好多水在线| 中文字幕av无码不卡免费| 久久人人做人人妻人人玩精品va| 日韩av无码精品人妻系列| 久久精品成人免费国产| 女人被狂躁高潮啊的视频在线看| 亚洲 中文字幕 日韩 无码|