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  4. Human Resistin-like Molecule β (RELM-β) ELISA Kit

Human Resistin-like Molecule β (RELM-β) ELISA Kit

  • 中文名稱：
    人抵抗素樣分子β (RELM-β)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13852h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人抵抗素樣分子β (RELM-β)酶聯(lián)免疫試劑盒（CSB-E13852h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液樣本中的RETNLB含量。RELM-β是一種由腸道杯狀細(xì)胞分泌的蛋白質(zhì)，在食物過敏中起關(guān)鍵作用。研究表明，RELM-β通過調(diào)節(jié)腸道微生物群，影響乳桿菌屬和另枝菌屬細(xì)菌的數(shù)量，從而破壞食物耐受性。其具體機制涉及與轉(zhuǎn)錄激活因子6（STAT6）的結(jié)合，以及Th2細(xì)胞因子IL-4和IL-13的誘導(dǎo)表達(dá)。試劑盒檢測范圍為47 pg/mL-3000 pg/mL，支持研究者開展炎癥性疾病模型評估、代謝綜合征機制探索、免疫細(xì)胞功能研究等基礎(chǔ)科研項目；適用于體外實驗體系中RELM-β的動態(tài)監(jiān)測，為腸道屏障功能研究、肺部纖維化模型構(gòu)建及免疫調(diào)控網(wǎng)絡(luò)解析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C/EBP epsilon regulated myeloid specific secreted cysteine rich protein precursor 2 ELISA Kit; CCGR ELISA Kit; Colon and small intestine specific cysteine rich protein ELISA Kit; Colon and small intestine-specific cysteine-rich protein ELISA Kit; Colon carcinoma related gene protein ELISA Kit; Colon carcinoma-related gene protein ELISA Kit; Cysteine rich secreted A12 alpha like protein 1 ELISA Kit; Cysteine rich secreted protein A12 alpha like 1 ELISA Kit; Cysteine rich secreted protein FIZZ2 ELISA Kit; Cysteine-rich secreted protein A12-alpha-like 1 ELISA Kit; Cysteine-rich secreted protein FIZZ2 ELISA Kit; FIZZ1 ELISA Kit; FIZZ2 ELISA Kit; Found in inflammatory zone 1 ELISA Kit; HXCP2 ELISA Kit; RELM beta ELISA Kit; RELMb ELISA Kit; RELMbeta ELISA Kit; Resistin like beta ELISA Kit; Resistin like protein beta ELISA Kit; Resistin-like beta ELISA Kit; RETNB_HUMAN ELISA Kit; RETNL2 ELISA Kit; Retnlb ELISA Kit; XCP2 ELISA Kit
  • 縮寫：
    RETNLB
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測范圍：
    47 pg/mL-3000 pg/mL
  • 靈敏度：
    11.7 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human RELM-β in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 85
    Range % 80-90
    1:2 Average % 96
    Range % 92-100
    1:4 Average % 90
    Range % 85-94
    1:8 Average % 92
    Range % 88-96
  • 回收率：
    The recovery of human RELM-β spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 101 95-106
    EDTA plasma (n=4) 95 90-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    3000 2.210 2.349 2.280 2.121
    1500 1.647 1.713 1.680 1.521
    750 1.129 1.092 1.111 0.952
    375 0.701 0.674 0.688 0.529
    187.5 0.438 0.457 0.448 0.289
    94 0.352 0.369 0.361 0.202
    47 0.224 0.235 0.230 0.071
    0 0.156 0.162 0.159 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable hormone.
  • 基因功能參考文獻(xiàn)：
    1. The human mesangial cells with up-regulated and down-regulated expression of RELM-beta increased or decreased significantly at 2-3 days. PMID: 28801998
    2. RELMbeta-overexpression can facilitate invasion and migration of gastric carcinoma cells. PMID: 27001185
    3. RELMbeta levels were increased in Abdominal aortic aneurysm patients in the serum and in the aortic tissue. Increased RELMbeta levels may be involved in the pathogenesis of AAA formation and progress. PMID: 25479529
    4. The data demonstrated that RELM-a is a promising novel biomarker of angiogenesis in patients with gastric cancer. PMID: 25937206
    5. elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins. PMID: 25545115
    6. It is concluded that proper exercise training prevents up-regulation of FIZZ1/RELMalpha induced by cigarette smoking, which may be involved in the mechanism of proper exercise training modulating airway hyperresponsiveness. PMID: 23392702
    7. RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation. PMID: 23702657
    8. Epithelial cell derived Fizz1 transgene is sufficient to increase bone-marrow derived dendritic cells in the lungs. PMID: 22726462
    9. RELM-beta may play an important role not only in animal models of airway remodelling, but also in human airway pathology. PMID: 22758223
    10. RELM-beta has the potential to contribute to airway remodelling in diseases such as asthma by acting on epithelial cells to increase proliferation, mucin and growth factor production, at least partly via ERK/MAPK-PI3K/Akt signalling pathways. PMID: 21828035
    11. Data show that over-expression of RELMbeta abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro. PMID: 22371635
    12. High RELMbeta is associated with colorectal cancer. PMID: 21094111
    13. FIZZ2 is highly induced in lungs of human patients with idiopathic pulmonary fibrosis. PMID: 21602491
    14. Gastric cncer patients showing positive RELMbeta expression had a significantly longer overall survival than those with negative expression (P = 0.001). PMID: 19967544
    15. High levels of RELMbeta can be detected in the stool of mice and humans, where it exists as a homodimer under nonreducing conditions. PMID: 14598255
    16. Of the 80 colon cancer patients studied, 65 (81.25%) tested positive for RELM beta, mainly in the cytoplasm of colon mucosa. PMID: 18594973
    17. Results suggest that RELM-beta may be involved in the development of scleroderma-associated pulmonary hypertension. PMID: 19251945
    18. Supernatant from COS cells transfected with the CCRG (RETNLB) expression vector stimulated proliferation of colon cancer cells, which supports the growth factor nature of the RETNLB gene. PMID: 12224133

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Resistin/FIZZ family
  • 組織特異性：
    Expressed only in the gastrointestinal tract, particularly the colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20388

    OMIM: 605645

    KEGG: hsa:84666

    STRING: 9606.ENSP00000295755

    UniGene: Hs.307047



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