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Human Prothymosin alpha (PTMA) ELISA Kit

  • 中文名稱:
    人胸腺肽α1(Thymosin α1)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E10028h
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人胸腺肽α1(Thymosin α1)酶聯(lián)免疫試劑盒(CSB-E10028h)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的PTMA含量。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL,適用于科研領(lǐng)域中對(duì)Thymosin α1表達(dá)水平的動(dòng)態(tài)監(jiān)測(cè),例如免疫機(jī)制研究、疾病模型評(píng)估或藥物干預(yù)效果分析等本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Prothymosin alpha (gene sequence 28) ELISA Kit; Prothymosin alpha ELISA Kit; Prothymosin alpha like 1 protein ELISA Kit; PTMA ELISA Kit; PTMA_HUMAN ELISA Kit; Thymalfasin ELISA Kit; Thymosin alpha 1 acetate ELISA Kit; Thymosin alpha 1 ELISA Kit; Thymosin alpha ELISA Kit; Thymosin alpha-1 ELISA Kit; TMSA ELISA Kit
  • 縮寫:
    PTMA
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長:
    450 nm
  • 研究領(lǐng)域:
    Signal Transduction
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human thymosin α1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:5 Average % 88  
    Range % 84-91  
    1:10 Average % 99  
    Range % 93-102  
    1:20 Average % 92  
    Range % 87-95  
    1:40 Average % 94  
    Range % 91-97  
  • 回收率:
    The recovery of human thymosin α1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 89-98  
    EDTA plasma (n=4) 88 84-91  
                 
                 
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    1000 2.759 2.711 2.735 2.567  
    500 2.026 1.987 2.007 1.839  
    250 1.301 1.268 1.285 1.117  
    125 0.766 0.745 0.756 0.588  
    62.5 0.470 0.487 0.479 0.311  
    31.2 0.336 0.344 0.340 0.172  
    15.6 0.288 0.277 0.283 0.115  
    0 0.169 0.167 0.168    
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
  • 基因功能參考文獻(xiàn):
    1. According to the cellular function of the characterized targets of ProTalpha, and the evolution in the composition of the diverse ProTalpha-complexes when proliferation activity was reduced or apoptosis induced, leads to hypothesized that ProTalpha interactions might be related to the proliferation activity and control of the cell survival. PMID: 29106904
    2. Prothymosin-alpha variants elicit anti-HIV-1 response via TLR4 dependent and independent pathways. PMID: 27310139
    3. PTMA is a potential novel therapeutic target for type 2 diabetes PMID: 26348351
    4. disease-free survival and overall survival rates were significantly lower among colorectal cancer patients with PTMA- and TP53-positive tumors PMID: 25197357
    5. Data suggest that KEAP1 (kelch-like ECH-associated protein 1) mutations (as those observed in lung cancer patients) affect conformation/folding/stability of KEAP1 and binding affinity for ligands PTMA and NRF2 (nuclear factor erythroid 2-like 2). PMID: 25582950
    6. Data suggest that plasma thymosin-alpha1 (TA1) and prothymosin-alpha (PTMA) level may be a biomarker for differentiating between renal cell carcinoma (RCC) and urothelial carcinoma. PMID: 22609059
    7. prothymosin-alpha expression is a determinant of disease progression in superficial bladder cancer PMID: 24733561
    8. PTalpha offers cardioprotection against ischemic injury by an Akt-dependent mechanism. PMID: 23857453
    9. phosphorylation of ProTalpha is required for its antiapoptotic activity, but it does not affect its nuclear import PMID: 23859021
    10. These results demonstrate the clinical relevance of prothymosin alpha in regulating acetylation events during the pathogenesis of emphysema. PMID: 23695700
    11. Western blot analysis of protein extracts from sperm head fractions confirms that the peptide is specifically associated with the inner acrosomal membrane fraction. PMID: 23359453
    12. ProTalpha is crucial for the interaction with the Kelch domain, while the flanking residues play relatively minor roles in the affinity of binding. PMID: 23318954
    13. The decrease of ProTalpha mRNA during differentiation was not accompanied by changes in the methylation status PMID: 22463375
    14. The prothymosin alpha is one of miR-1 target genes which involve in miR-1 inducing apoptosis PMID: 22059741
    15. Findings suggest that the binding of prothymosin alpha (ProTalpha) and Neh2 to Keap1 occurs synergistically via preformed structural elements. PMID: 22125611
    16. The PTMA is one of miR-1 target genes which involve in miR-1 inducing apoptosis. PMID: 22059741
    17. when added to cultured cells expressing mHtt, the purified recombinant ProTalpha protein not only entered the cells but it also significantly suppressed the mHtt-caused cytotoxicity. PMID: 22110140
    18. Nuclear PTMA may serve as prognostic marker in head and neck squamous cell carcinoma to determine the subset of patients that are likely to show recurrence of the disease. PMID: 21573209
    19. These results are consistent with the model that ProTa may enhance p53 transcription activity by displacement of histone H1 from p53-H1 repressive complex. PMID: 21954601
    20. A study on the relationship between prothymosin alpha kinase(ProTalphaK) activity and pyruvate kinase isoforms confirmed that the M2 isoform is the enzyme responsible for ProTalphaK activity in proliferating cells. PMID: 20977946
    21. Data suggest that prothymosin alpha immunostaining may be helpful in predicting pituitary tumor recurrence. PMID: 20430720
    22. Prothymosin alpha amino acid residues 4-14, 31-43, 84-87, and 106-110 strongly and specifically bind to apoptotic protease activating factor 1 (Apaf-1) in the regulation of the mitochondrial cell death pathway. PMID: 20121050
    23. we demonstrate the existence of three binding partners (31, 29, and 19 kDa) for ProTalpha in the membrane of PHA-activated lymphoblasts. These surface molecules possess the expected affinity and specificity for a ProTalpha receptor PMID: 11727831
    24. prothymosin alpha is capable of forming regular elongated fibrils PMID: 12062405
    25. regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis PMID: 12522243
    26. study suggests involvement of prothymosin a, in the formation, maintenance, or functioning of the mitotic spindle PMID: 15325071
    27. PTMA associates with SET and is involved in chromatin decondensation. PMID: 15556635
    28. Prothymosin alpha functions as intranuclear dissociator of the Nrf2-Keap1 complex. PMID: 15657435
    29. PTMA expression is intimately involved in the differentiation and progression of human prostate cancers, and could be a target for therapy and diagnostic purposes. PMID: 16353248
    30. Antiapoptotic response of cells requires expression of both p8 and ProTalpha. PMID: 16478804
    31. the anti-apoptotic effect previously attributed separately to p8 and prothymosin alpha is in fact borne by the p8/ProTalpha complex, the two proteins being individually inactive PMID: 16628001
    32. Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells. PMID: 16669873
    33. suppression of viral replication by ProTalpha is not HIV LTR specific PMID: 16940531
    34. interaction of ProTalpha with core histones in the nucleus may be related to structural modification of histones H3 & H4, & hence to chromatin activity, raising the possibility that other proteins in the nuclear complex may play a role in this process. PMID: 17012289
    35. Decreased ERbeta and increased ProTalpha expression in advanced gastric adenocarcinoma indicated that ERbeta may play an anti-proliferation role which is opposed to the role of ProTalpha in gastric epithelium. PMID: 17046193
    36. although prothymosin-alpha is overexpressed in gastric adenocarcinoma, it is not associated with alterations in survival PMID: 17188166
    37. PTMA may be a novel marker for predicting the effectiveness of radiotherapy in clinical cases. PMID: 17876542
    38. Basis on site-specific information obtained here, as well as results from previous studies, we propose that the conformational and dynamic changes upon zinc binding may act as an entropic switch that greatly facilitates the binding to other proteins PMID: 17929838
    39. ProTalpha and Nrf2 compete for interaction with Keap1, therefore ProTalpha is able to liberate Nrf2 from complex with Keap1 and hence contribute to Nrf2-dependent transcription. PMID: 18240569
    40. Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor PMID: 18856068
    41. immune response stimulation by ProTalpha is in principle exerted via its bioactive C-terminal decapaptide, which can acquire a sequence-specific beta-sheet conformation and induce DC maturation. PMID: 18976813
    42. induces unravelling of metaphase chromosomes in vitro PMID: 11528108

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  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Pro/parathymosin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9623

    OMIM: 188390

    KEGG: hsa:5757

    STRING: 9606.ENSP00000344547

    UniGene: Hs.459927



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