在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Properdin(CFP) ELISA kit

  • 中文名稱:
    人備解素(CFP)酶聯免疫試劑盒
  • 貨號:
    CSB-EL005291HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人備解素(CFP)酶聯免疫試劑盒(CSB-EL005291HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的CFP含量。人備解素(CFP)是一種調節補體旁路途徑的蛋白,其功能是穩定C3bBb復合物,阻止其衰變,從而增強補體系統的病原體清除能力。CFP的研究涉及其在免疫應答中的作用,以及其與遺傳性或獲得性補體異常疾病的關系。試劑盒檢測范圍為12.5 ng/mL-800 ng/mL,適用于科研領域中對CFP的定量分析,如探究疾病發生機制、評估實驗模型中補體通路活性變化、篩選調控補體系統的藥物靶點等場景本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    BFD ELISA Kit; CFP ELISA Kit; Complement factor P ELISA Kit; Complement factor properdin ELISA Kit; Factor P ELISA Kit; PFC ELISA Kit; PFD ELISA Kit; PROP_HUMAN ELISA Kit; Properdin ELISA Kit; Properdin P factor complement ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    12.5 ng/mL-800 ng/mL
  • 靈敏度:
    3.12 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human CFP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:100Average %95
    Range %90-100
    1:200Average %106
    Range %101-110
    1:400Average %98
    Range %92-103
    1:800Average %90
    Range %85-97
  • 回收率:
    The recovery of human CFP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8480-90
    EDTA plasma (n=4)9389-98
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1OD2AverageCorrected
    8002.378 2.224 2.301 2.200
    4001.754 1.852 1.803 1.702
    2001.088 1.124 1.106 1.005
    1000.687 0.642 0.665 0.564
    500.364 0.383 0.374 0.273
    250.245 0.233 0.239 0.138
    12.50.171 0.162 0.167 0.066
    00.098 0.104 0.101
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    A positive regulator of the alternate pathway (AP) of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
  • 基因功能參考文獻:
    1. In conclusion, we challenge the view of properdin as a pattern recognition molecule by providing evidence that it binds to different exogenous and endogenous molecular patterns in only a C3-dependent manner. PMID: 28069958
    2. data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation PMID: 27183616
    3. this study shows that RNA interference of properdin in dendritic cells decreased alloantigen-specific T-cell proliferation PMID: 28105653
    4. studies demonstrate an essential role of properdin oligomerization in vivo while our monomers enable detailed structural insight paving the way for novel modulators of complement. PMID: 28264884
    5. P serum level expression could be a reliable clinical biomarker to identify patients with underlying surface alternative pathway C5 convertase dysregulation. PMID: 26660535
    6. can directly interact with neutrophil myeloperoxidase resulting in activation of alternative pathway of complement PMID: 24355864
    7. In the pathogenesis of renal tubular damage, P can directly bind to PTECs and may accelerate AP activation by surpassing fH regulation PMID: 24885016
    8. Our data show that physiological forms of human properdin bind directly to human platelets after activation by strong agonists in the absence of C3 PMID: 23677468
    9. Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. PMID: 22815489
    10. Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner. PMID: 22851705
    11. Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation. PMID: 22338105
    12. Immune human serum that contained bactericidal Abs directed against the 2C7 lipooligosaccharide epitope required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains. PMID: 22368277
    13. report a large Finnish family with a novel mutation in the properdin gene. The mutation is located in exon 9 and changes guanine to adenine at nucleotide 1164 (c.1164G>A) that causes tryptophan to change to a premature stop codon (W388X). PMID: 22229731
    14. tubular HS as a novel docking platform for alternative pathway activation via properdin, which might play a role in proteinuric renal damage. PMID: 21135110
    15. levels of properdin are not associated with childhood wheezing and atopy PMID: 20337960
    16. Human properdin can selectively recognize surfaces and enhance or promote alternative pathway of complement activation. PMID: 20382442
    17. The conventional mechanism of properdin function is to bind to and stabilize alternative pathway C3 convertases on the surface of Neisseria meningitidis and N. gonorrhoeae. PMID: 20530262
    18. Properdin presence is associated with increased SC5b-9 excretion and worse renal function. PMID: 19934084
    19. CFP does not seem to confer any risk for age-related macular degeneration. PMID: 20122735
    20. A splice site mutation in exon 10 (c.1487-2A>G) was found in the properdin gene and co segregated with biochemically measured properdin deficiency. PMID: 16337490
    21. study reports properdin binds predominantly to late apoptotic & necrotic cells but not to early apoptotic cells; binding occurs independently of C3b PMID: 18490764
    22. The human complement protein properdin binds to early apoptotic T cells and initiates complement activation, leading to C3b opsonization and ingestion by phagocytic cells. PMID: 18579773
    23. The contribution of properdin is pivotal in proteinuria-induced tubular complement activation and subsequent damage. Interference with properdin binding to tubular cells may provide an option for the treatment of proteinuric renal disease. PMID: 18753294
    24. Properdin induces the formation of platelet-leukocyte aggregates via leukocyte activation, linking the complement system & platelet-leukocyte aggregates with potential significance in atherosclerotic vascular disease. PMID: 18791942
    25. Significantly more transcripts encoding alternative pathway components factor B, C3 and properdin, and C3a receptor and C5a receptor were detected in grade 3 versus grade 0 or 1 biopsies of human cardiac allografts. PMID: 19005416
    26. Factor P was expressed in 50% of choroidal neovascular membranes of patients with age-related macular degeneration(AMD). Additional studies need to investigate role of Factor P in development of AMD for potential therapeutic intervention. PMID: 19584655

    顯示更多

    收起更多

  • 相關疾病:
    Properdin deficiency (PFD)
  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 8864

    OMIM: 300383

    KEGG: hsa:5199

    STRING: 9606.ENSP00000247153

    UniGene: Hs.53155



主站蜘蛛池模板: 国产成人午夜福利免费无码r| 亚洲综合色在线视频www| 日韩a毛片免费观看| 国产亚洲日韩av在线播放不卡| 1000部夫妻午夜免费| 免费做爰猛烈吃奶摸视频在线观看 | 在线亚洲高清揄拍自拍一品区| 精品四虎国产在免费观看| 亚洲伦无码中文字幕另类| 女厕厕露p撒尿八个少妇| 精品国产一区二区三区香蕉| 午夜高清在线无码| 日本wv一本一道久久香蕉| 国产精品天天狠天天看| 又粗又大内射免费视频小说| 久久久www成人免费精品| 日本人妻中文字幕乱码系列| 好爽好硬好深高潮视频456| 苍井空浴缸大战猛男120分钟| 国内揄拍国内精品人妻| 又黄又湿啪啪响18禁| 国产精品无码av一区二区三区| 国产女人高潮叫床视频| 免费无码av片在线观看动漫 | 亚洲国产av导航第一福利网| 99久热re在线精品99re8热视频| 久久精品国产精品| 亚洲国产精品久久久天堂不卡海量| 男人靠女人的免费视频| 欧美老熟妇xb水多毛多| 午夜影视啪啪免费体验区入口| 自偷自拍亚洲综合精品麻豆| 国产成人无码av一区二区在线观看| 99久久精品国产一区二区三区| 噜噜噜av久久av苍井空| 亚洲国产欧美在线人成最新| 国产欧美日韩精品a在线观看| 无码人妻精品中文字幕不卡| 久久99九九精品久久久久蜜桃| 欧美成人精品三级网站| 亚洲在av人极品无码|