在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Prolactin Inducible Protein(PIP)ELISA Kit

  • 中文名稱:
    人催乳素誘導蛋白(PIP)酶聯免疫試劑盒
  • 貨號:
    CSB-E15980h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人催乳素誘導蛋白(PIP)酶聯免疫試劑盒(CSB-E15980h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的PIP含量。人催乳素誘導蛋白(PIP)是一種與催乳素相關的蛋白,主要作用是促進泌乳過程。其研究機制涉及下丘腦-垂體軸的調節,通過影響乳腺發育、乳汁分泌和維持乳汁分泌等環節,對泌乳障礙的婦女具有臨床應用價值。試劑盒檢測范圍為0.055 ng/ml- 40ng/ml,靈敏度為0.055 ng/ml。適用于乳腺癌機制研究、激素調控通路分析、細胞增殖與免疫調節實驗等科研領域。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    BRST-2 ELISA Kit; BRST2 ELISA Kit; GCDFP-15 ELISA Kit; GCDGP15 ELISA Kit; gp17 ELISA Kit; GPIP4 ELISA Kit; Gross cystic disease fluid protein 15 ELISA Kit; PIP ELISA Kit; PIP_HUMAN ELISA Kit; Prolactin induced protein ELISA Kit; Prolactin inducible protein precursor ELISA Kit; Prolactin-induced protein ELISA Kit; Prolactin-inducible protein ELISA Kit; SABP ELISA Kit; Secretory actin binding protein ELISA Kit; Secretory actin-binding protein ELISA Kit
  • 縮寫:
    PIP
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 靈敏度:
    0.05 ng/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Others
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple Lewis(Y) epitopes generate highly-fucosylated glycan structures. PMID: 29858715
    2. that GATA3 is a very sensitive marker for primary genital extramammary Paget diseases and is more sensitive than gross cystic disease fluid protein 15 PMID: 28693610
    3. monoclonal antibodies to GATA-3 are very sensitive reagents for the identification of breast CA, surpassing antibodies to GCDFP-15 and mammaglobin A, and offer a significant improvement in identifying TNBCs PMID: 26447897
    4. good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75) PMID: 28038704
    5. High expression of GCDFP-15 is associated with molecular apocrine breast cancer. PMID: 26711786
    6. While highly expressed under pathological conditions of the mammary gland, including breast cancers, PIP is expressed in very few other cancers. Although the function of PIP is not well elucidated, numerous studies suggest that its primary role may be related to host defense and immune modulation. Studies in Pip null mice suggest that PIP may play a similar immune-regulatory role in breast cancer. [Review] PMID: 27602994
    7. novel marker GATA3 stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples PMID: 25906123
    8. In summary, this study suggests that PIP expression regulates the process of cell adhesion in breast cancer. PMID: 26585492
    9. GCDFP15 in stratum corneum is a potential marker for dysregulated sweating in atopic dermatitis. PMID: 25919462
    10. The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 and MGB were not associated with outcome. PMID: 25425335
    11. Data indicate the potential role of Gross cystic disease fluid protein-15/prolactin-inducible protein (GCDFP-15/PIP) as a biomarker for keratoconus (KC)disease. PMID: 25405607
    12. Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. PMID: 22817771
    13. GCDFP-15 expression is higher in tumors with favorable prognostic features. GCDFP-15 expression is further a frequent feature of androgen receptor positive tumors and the molecular apocrine subtype. PMID: 25070172
    14. PIP is a breast cancer-related protein that is expressed in a majority of breast tumors and has a significant function in the biology of this disease. [review] PMID: 25472539
    15. we found that HER2 or GCDFP15 protein overexpression is a sensitive and specific tool to differentiate MA from BL in the context of ER negative tumors. PMID: 23663520
    16. The roles of PIP in the related T47D breast cancer cell line, were investigated. PMID: 23755096
    17. PIP is required for cell cycle progression in breast cancer and provides a rationale for exploring PIP inhibition as a therapeutic approach in breast cancer that can potentially target microtubule polymerization. PMID: 24862759
    18. Report GCDFP15 expression in metastatic basal-like triple negative breast carcinomas. PMID: 24272937
    19. AZGP1 and PIP were found in significantly lower levels in invasive breast tissue. PMID: 24114735
    20. GCDFP-15 was associated significantly with a breast cancer profile of good prognosis tumors. PMID: 23332923
    21. Gross cystic disease fluid protein-15 and mammaglobin A expression determined by immunohistochemistry is of limited utility in triple-negative breast cancer. PMID: 22963676
    22. Interaction analysis identifies semenogelin I fragments as new binding partners of PIP in human seminal plasma PMID: 23085372
    23. GCDFP-15 alone is not a useful marker to detect the metastasis of basaloid type breast cancers. PMID: 23011826
    24. expression was down-regulated in azoospermia, indicating that PIP may be a plausible marker of azoospermia PMID: 22724438
    25. The first report of native human serum albumin (HSA)-PIP complex formation in seminal plasma. PMID: 22209935
    26. abnormal development of the prepuce in hypospadias is associated with variation in PIP expression PMID: 21883842
    27. Data suggest that Runx2 controls a positive feedback loop between androgen signaling and PIP, and pharmacological inhibition of PIP may be useful to treat PIP positive tumors. PMID: 21809344
    28. Most basal-like breast carcinomas and unclassified triple-negative carcinomas are negative for mammaglobin and gross cystic disease fluid protein 15. PMID: 21411781
    29. expressed on a small subset of primary lung adenocarcinomas PMID: 19620839
    30. Intragenic amplification and formation of extrachromosomal small circular DNA molecules from the PIP gene on chromosome 7 in primary breast carcinomas PMID: 11992405
    31. different conformations and/or tissue-specific posttranslational modifications of the proteins, although their primary structure was identical by MS/MS analysis PMID: 12755619
    32. Forms a protein complex with PIG-F and is involved in the conversion of phosphatidylinositol glycans. PMID: 15632136
    33. The sensitivity of mammaglobin is equal or superior to that of GCDFP-15 for investigation of breast carcinoma. PMID: 18251583
    34. analysis of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma PMID: 18930737
    35. Both MGB1 and GCDFP-15 are specific markers for metastatic breast carcinomas in cell block fluid specimens (88 vs. 96%). PMID: 19217055
    36. importance of a regulatory subnetwork associated with PIP expression in which STAT5 appears as a potential transcriptional regulator PMID: 19262752
    37. PIP(alternate name GCDFP-15, gp17) is a secretory marker of apocrine differentiation in breast carcinoma. It is an aspartyl proteinase with specificity restricted for fibronectin. PMID: 10713110

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    PIP family
  • 組織特異性:
    Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.
  • 數據庫鏈接:

    HGNC: 8993

    OMIM: 176720

    KEGG: hsa:5304

    STRING: 9606.ENSP00000291009

    UniGene: Hs.99949



主站蜘蛛池模板: www一区二区www免费| 9lporm自拍视频区| 亚洲一区二区| 久久综合伊人77777| 在线看片免费人成视频福利| 国产高清女同学巨大乳在线观看 | 超清无码波多野吉衣中文 | 免费乱码人妻系列无码专区| 亚洲乱妇老熟女爽到高潮的片| 免费无码黄动漫在线观看| 天天看片天天av免费观看| 97久久超碰国产精品旧版麻豆| 久久精品国产99国产精品| 免费观看激色视频网站| 欧洲亚洲国产成人综合色婷婷| 97人摸人人澡人人人超碰| 欧美三根一起进三p| 亚洲熟女综合一区二区三区| 国产乱人伦偷精品视频下| 2021国产精品午夜久久| 国产亚洲精品久久久久久青梅| 久久久精品2020免费观看| 人妻中出无码一区二区三区| 亚洲综合色区中文字幕| 在线观看无码不卡av| 精品国产福利一区二区| 97狠狠狠狼鲁亚洲综合网| 亚州av综合色区无码一区| 国模小婕私拍鲜嫩玉门| 久久ee热这里只有精品| 色视频www在线播放国产人成| 兔费看少妇性l交大片免费| 久久国产福利一区二区| 国产精品va在线播放| 色综合久久无码五十路人妻| 午夜在线a亚洲v天堂网2018 | 久久ww精品w免费人成| 日本体内she精高潮| 久久久久无码精品国产人妻无码| 亚洲自偷自拍另类小说| 狠狠的干性视频|