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  4. Human Pregnancy Specific β1 Glycoprotein (SP1/PSβ1-G) ELISA kit

Human Pregnancy Specific β1 Glycoprotein (SP1/PSβ1-G) ELISA kit

  • 中文名稱：
    人妊娠特異性β1糖蛋白(SP1/PSβ1-G)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09133h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人妊娠特異性β1糖蛋白(SP1/PSβ1-G)酶聯(lián)免疫試劑盒（CSB-E09133h）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SP1/PSβ1-G含量。人妊娠特異性β1糖蛋白（SP1/PSβ1-G）是由胎盤合體滋養(yǎng)層細胞合成的特異性糖蛋白，具有免疫調節(jié)、抗炎和促血管生成作用。其結構/功能關系研究顯示，SP1可以與多種調節(jié)蛋白協(xié)同作用，通過保守的短線性基序參與蛋白質-蛋白質相互作用，對藥物設計和疾病診斷具有重要意義。試劑盒檢測范圍為1.0 μg/mL-400 μg/mL，適用于科研領域中對妊娠期母體血清或胎盤組織勻漿中SP1水平的動態(tài)監(jiān)測，可應用于探究妊娠高血壓、胎兒生長受限等病理狀態(tài)下胎盤功能異常的分子機制，或用于評估體外模型中滋養(yǎng)層細胞分泌蛋白的功能研究。本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
  • 別名：
    B1G1 ELISA Kit; Carcinoembryonic antigen SG8 ELISA Kit; CD66 antigen-like family member F ELISA Kit; CD66f ELISA Kit; CD66f antigen ELISA Kit; CEA ELISA Kit; DHFRP2 ELISA Kit; Fetal liver non-specific cross-reactive antigen 1/2 ELISA Kit; FL-NCA-1/2 ELISA Kit; PBG 1 ELISA Kit; PBG1 ELISA Kit; Pregnancy specific B 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein 1 ELISA Kit; Pregnancy specific beta 1 glycoprotein 2 ELISA Kit; Pregnancy specific beta 1 glycoprotein 7 ELISA Kit; Pregnancy specific beta 1 glycoprotein 8 ELISA Kit; Pregnancy specific beta 1 glycoprotein ELISA Kit; Pregnancy specific beta 1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1 glycoprotein C/D ELISA Kit; Pregnancy-specific beta-1-glycoprotein 1 ELISA Kit; Pregnancy-specific glycoprotein 1 ELISA Kit; PS beta C/D ELISA Kit; PS-beta-C/D ELISA Kit; PS-beta-G-1 ELISA Kit; PSBG 1 ELISA Kit; PSBG 2 ELISA Kit; PSBG-1 ELISA Kit; PSBG1 ELISA Kit; PSBG2 ELISA Kit; PSG 1 ELISA Kit; PSG 2 ELISA Kit; PSG 8 ELISA Kit; PSG 95 ELISA Kit; PSG IIA d ELISA Kit; PSG1 ELISA Kit; PSG1_HUMAN ELISA Kit; PSG2 ELISA Kit; PSG8 ELISA Kit; PSG95 ELISA Kit; PSGGA ELISA Kit; PSGGB ELISA Kit; PSGIIA a ELISA Kit; PSGIIA ELISA Kit; PSGIIA b ELISA Kit; PSGIIA c ELISA Kit; SP 1 ELISA Kit; SP1 ELISA Kit
  • 縮寫：
    SP1/PSβ1-G
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.0 μg/mL-400 μg/mL
  • 靈敏度：
    1.0 μg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Tags & Cell Markers
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<15%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %96
    Range %89-106
    1:2Average %90
    Range %89-104
    1:4Average %95
    Range %88-100
    1:8Average %87
    Range %82-99
  • 回收率：
    The recovery of human SP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9586-107
    EDTA plasma (n=4)9791-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    μg/mlOD1OD2Average
    4000.139 0.144 0.142
    750.269 0.278 0.274
    12.50.534 0.556 0.545
    3.50.853 0.873 0.863
    11.452 1.464 1.458
    02.137 2.161 2.149
  • 數(shù)據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-beta (TGF-beta)-related pathway in ER-negative breast cancer cells. PMID: 27653744
    2. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-gamma. PMID: 27595833
    3. Under conditions of directed induction of phenotypic changes in CD4(+) lymphocytes to regulatory T cells (Treg), pregnancy-specific at high concentrations (10 and 100 mug/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that pregnancy-specific beta1-glycoprotein (1 and 100 mug/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4(+) lym... PMID: 27817017
    4. results identify a non-placental site of PSG expression in the gut and associated tumors, with implications for determining whether PSGs have a role in tumor progression, and utility as tumor biomarkers. PMID: 26926266
    5. the presence of GAGs on the surface of endothelial cells was required for the ability of PSG1 to induce tube formation PMID: 21193412
    6. The aspartic acid at position 95 is not required for PSG1 activity but the amino acids implicated in the formation of a salt bridge within the N-domain are essential. PMID: 20335639
    7. first trimester maternal serum marker of small-for-gestational age and preterm delivery PMID: 19911417
    8. Human PSG1a induces alternative activation in human & mouse monocytes & suppresses the accessory-cell-dependent T-cell proliferation. PSG1a contributes to immunomodulation during pregnancy, with opposite effects on maternal innate & adaptative systems. PMID: 12223519
    9. The differential expression of HLA-E and PSG1 in the sperm of fertile and infertile men is discussed. PMID: 18987160

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 數(shù)據庫鏈接：

    HGNC: 9514

    OMIM: 176390

    KEGG: hsa:5669

    STRING: 9606.ENSP00000244296

    UniGene: Hs.709192



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