在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Placenta Cadherin,P-cad ELISA Kit

  • 中文名稱:
    人P鈣黏蛋白/胎盤鈣黏蛋白(P-cad)酶聯免疫試劑盒
  • 貨號:
    CSB-E08955h
  • 規格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人P鈣黏蛋白/胎盤鈣黏蛋白(P-cad)酶聯免疫試劑盒(CSB-E08955h)檢測樣本中的CDH3含量。CDH3,又稱胎盤鈣粘蛋白,是鈣粘蛋白家族的一員,參與細胞粘附和信號轉導。其在惡性腫瘤中過量表達,可作為靶點進行小分子藥物或抗體研究。研究機制顯示,CDH3在腫瘤細胞增殖和侵襲中起重要作用,可作為腫瘤風險評估和預后監測的分子標志物。適用于腫瘤微環境研究、細胞極性分析、干細胞分化模型構建等科研場景,為探索上皮 - 間質轉化機制或組織修復調控提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadherin
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻:
    1. the evaluation of P-cadherin expression in lymph node metastases is an important predictor of disease outcome in breast cancer axillary lymph node metastases PMID: 28084338
    2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
    3. Ophthalmologists should consider the diagnosis of CDH3-related retinopathy in individuals with such clinical features whether or not there is frank hypotrichosis. PMID: 26885695
    4. Adhesive dimerization of human P-cadherin catalyzed by a chaperone-like mechanism has been described. PMID: 27545624
    5. Results strongly advocated a pathogenic potential of the novel variants of CDH3 for the HJMD phenotypes. PMID: 27456782
    6. CDH3-related disease is characterized by a childhood-onset, progressive chorioretinal atrophy confined to the posterior pole. PMID: 27386845
    7. This study aimed to demonstrate the usefulness of mRNA expression levels of cadherin 3 (CDH3) in brush cytology specimens combined with cytology for the diagnosis of malignant biliary stricture PMID: 27399126
    8. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. PMID: 26771841
    9. The P-cadherin structure and packing arrangement provide new and valuable information towards the complete structural characterization of the cadherin dimerization pathway. PMID: 25849494
    10. In patients with breast infiltrating ductal carcinoma, P-cadherin was expressed in 40.5% of cases; P-cadherin expression had a negative relationship with the overall survival PMID: 26299056
    11. results establish a link between aberrant P-cadherin expression and hypoxic, glycolytic and acid-resistant breast cancer cells, suggesting a possible role for this marker in cancer cell metabolism PMID: 25269858
    12. Downregulation of P-cadherin expression appears to induce tumorigenicity in hepatocellular carcinoma. PMID: 25337260
    13. P-cadherin is able to potentiate ligand-dependent signaling of insulin-like growth factor 1 receptor in malignant keratinocytes and epidermal growth factor receptor in dysplastic cells. PMID: 25322858
    14. These findings indicate that HOXA9 contributes to poor outcomes in Epithelial ovarian cancer in part by promoting intraperitoneal dissemination via its induction of P-cadherin. PMID: 25023983
    15. The X-dimer plays a key role in the specific cell-cell adhesion mediated by human P-cadherin. PMID: 24559158
    16. Increased expression of CDH3 is associated with colorectal cancer. PMID: 23682078
    17. Loss of P-cadherin expression is associated with oral squamous cell carcinoma. PMID: 23740836
    18. P-cadherin and vimentin could be adjunctive to the commonly used immunohistochemical surrogates for basal-like breast cancer identification PMID: 24139214
    19. High CDH3 expression is associated with aggressive breast tumour behaviour. PMID: 23405208
    20. P-cadherin-mediated signaling is a melanocyte subtype-specific topobiological regulator of normal human pigmentation, possibly via GSK3beta-mediated canonical Wnt signaling. PMID: 23334344
    21. LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin PMID: 22531681
    22. Hypotrichosis associated with juvenile macular dystrophy is caused by mutations in CDH3, which encodes P-cadherin, a member of the classic cadherin family. PMID: 23143461
    23. P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-beta2. PMID: 22696062
    24. Compared with conventional carcinomas, serrated adenocarcinomas showed no significant difference in P-cadherin staining. PMID: 22209340
    25. A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy PMID: 22348569
    26. High P-cadherin promotes liver metastasis and is associated with colon cancer. PMID: 21703417
    27. P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. PMID: 21317933
    28. a novel splice site mutation (c.IVS10-1 G --> A) in intron 10, which leads to skipping of exon 11 in CDH3 gene in family with hypotrichosis with juvenile macular dystrophy PMID: 20140736
    29. P-cadherin positivity is associated with high-grade breast cancer subtypes and well-established markers of poor prognosis. PMID: 20852590
    30. Stable knockdown of P-cadherin in RT-112 cells diminished invasion and migration, and promoted intercellular adhesion PMID: 20473917
    31. Data conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells. PMID: 20860798
    32. P-cadherin and CD24 are expressed in carcinomas of the biliary tract with high frequency and at an early stage of carcinogenesis. PMID: 20621328
    33. Overexpression of CDH3 is associated with basal-like phenotype in breast cancer. PMID: 19882246
    34. C/EBPbeta is able to up-regulate CDH3 promoter activity in breast cancer cells; the expression of P-cadherin linked with a worse prognosis of breast cancer patients PMID: 20385540
    35. 2 splice site mutations (one novel and one recurrent mutation) were in the CDH3 gene leading to hypotrichosis with juvenile macular dystrophy. PMID: 20203473
    36. P-cadherin gene expression proved to be a significant independent prognostic factor for both cancer-specific and recurrence-free survival in bladder cancer PMID: 20204300
    37. high levels of 80 kDa sP-cadherin in human milk. PMID: 11891861
    38. results point to the close relationship between the de novo expression of P-cadherin and the disruption of the cadherin/catenins complex with the squamoid phenotype of mucoepidermoid carcinoma of the thyroid (MECT) PMID: 12021924
    39. may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner PMID: 12112590
    40. Regulated expression of P-cadherin/beta-catenin complexes in ovarian tumor cells may represent a key step in disease progression PMID: 12800191
    41. Inappropriate PCAD expression in mouse mammary epithelium is compatible with normal mammary gland function. PMID: 12919105
    42. An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma. PMID: 15375751
    43. In summary, we have ascertained a third gene associated with ectrodactyly and have demonstrated a hitherto unrecognised role of CDH3 in shaping the human hand PMID: 15805154
    44. A short truncated 50 kDa form of the N-terminal part of P-cadherin expresses in melanoma cell lines compared to melanocytes and keratinocytes. PMID: 15817166
    45. P-cadherin may have a role in progression of oral squamous cell carcinoma PMID: 15967043
    46. P-cadherin expression was strongly associated with tumor aggressiveness, being a good indicator of clinical outcome, and the aberrant expression of P-cadherin in breast cancer might be regulated by gene promoter hypomethylation. PMID: 16115928
    47. Novel heterozygous CDH3 mutations in hypotrichosis with juvenile macular dystrophy in two nonconsaguineous families. PMID: 17342797
    48. P-cadherin may be regarded as an additional immunohistochemical marker of basal-like breast carcinomas. PMID: 18074863
    49. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans. PMID: 18199584
    50. Tunisian IBCs are characterized by frequent basal and ERBB2 phenotypes. Surprisingly, luminal inflammatory breast cancer also express the basal marker P-cadherin. PMID: 18230143

    顯示更多

    收起更多

  • 相關疾病:
    Hypotrichosis congenital with juvenile macular dystrophy (HJMD); Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in some normal epithelial tissues and in some carcinoma cell lines.
  • 數據庫鏈接:

    HGNC: 1762

    OMIM: 114021

    KEGG: hsa:1001

    STRING: 9606.ENSP00000264012

    UniGene: Hs.191842



主站蜘蛛池模板: 97人人超碰国产精品最新| 亚洲偷自拍国综合色帝国| 日韩av第一页在线播放| 亚洲精品偷拍无码不卡av| 国产精品午夜剧场免费观看| 农村欧美丰满熟妇xxxx| 亚洲综合色自拍一区| 色综合视频一区中文字幕| 高清国产亚洲欧洲av综合一区| 涩涩鲁亚洲精品一区二区| 亚洲欧美国产精品久久| 乱码丰满人妻一二三区| 欧美亚洲人成网站在线观看| 综合自拍亚洲综合图区高清| 久久久久亚洲精品中文字幕 | 久久久久se色偷偷亚洲精品av| 久久久无码精品午夜| 蜜臀av色欲a片无码一区| 毛片无遮挡高清免费| 天码av无码一区二区三区四区| 日本在线看片免费人成视频| 永久中文字幕免费视频网站| 精品国产天线2019| 国产精品无码mv在线观看| 国产精品69人妻无码久久| 99久久精品国产波多野结衣| 国产真人无遮挡作爱免费视频| 国产成人精品午夜福利在线观看| 午夜国产成人片在线播放| 欧美多毛肥胖老妇做爰| 四房播播开心五月| 狠狠躁夜夜躁人人爽天天古典| 国产精品视频色拍在线视频| 亚洲国产av一区二区三区四区| 一边添奶一边添p好爽视频| 波多野结衣乱码中文字幕| 人妻少妇88久久中文字幕| 精品av无码国产一区二区| 欧美肥胖老太vidio在线视频| 日本三级在线播放线观看视频| 国产成人免费一区二区三区|