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  4. Human Pappalysin-2(PAPPA2) ELISA kit

Human Pappalysin-2(PAPPA2) ELISA kit

  • 中文名稱：
    人冠毛素-2(PAPPA2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL017436HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人冠毛素-2(PAPPA2)酶聯免疫試劑盒（CSB-EL017436HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液、組織勻漿樣本中的PAPPA2含量。PAPPA2是一個有研究價值的靶點。其在多種生理與病理過程中可能發揮作用。研究機制上，主要聚焦于它在細胞增殖、分化及腫瘤發生發展等方面的影響，探索其信號通路及相關分子作用方式，以尋找潛在治療干預點。試劑盒檢測范圍為2 ng/mL-60 ng/mL，適用于基礎醫學研究領域，如探索PAPPA2在胚胎發育、腫瘤微環境調控或代謝性疾病模型中的作用機制，也可用于動物實驗中生物標志物動態變化的監測本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    PAPPA 2 ELISA Kit; PAPP E ELISA Kit; PAPP-A2 ELISA Kit; PAPP-E ELISA Kit; PAPP2_HUMAN ELISA Kit; PAPPA2 ELISA Kit; Pappalysin 2 ELISA Kit; Pappalysin-2 ELISA Kit; PLAC3 ELISA Kit; Pregnancy associated plasma protein A2 ELISA Kit; Pregnancy associated plasma protein E1 ELISA Kit; Pregnancy-associated plasma protein A2 ELISA Kit; Pregnancy-associated plasma protein E1 ELISA Kit
  • 縮寫：
    PAPPA2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, urine, tissue homogenates
  • 檢測范圍：
    2 ng/mL-60 ng/mL
  • 靈敏度：
    0.5 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<15%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PAPPA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 90    
    Range % 85-98    
    1:2 Average % 92    
    Range % 88-99    
    1:4 Average % 94    
    Range % 90-101    
    1:8 Average % 94    
    Range % 86-102    
  • 回收率：
    The recovery of human PAPPA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 97 92-100    
    EDTA plasma (n=4) 95 88-99    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    60 2.517 2.483 2.500 2.453    
    25 1.294 1.328 1.311 1.264    
    10 0.614 0.626 0.620 0.573    
    4 0.311 0.299 0.305 0.258    
    2 0.159 0.156 0.158 0.111    
    0 0.046 0.047 0.047 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.
  • 基因功能參考文獻：
    1. PAPP-A2 mutation is associated with idiopathic short stature. PMID: 29653372
    2. The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA, PAPPA2 and PLAC-1. PMID: 29532882
    3. Pregnancy associated plasma protein-A (PAPP-A) appears to be a potentially useful biomarker for short-term risk stratification of patients presenting with chest pain of ischemic origin (Review). PMID: 29144175
    4. PAPP-A2 is increased in Hemodialysis patients and interacts with PAPP-A on patients prognosis. PMID: 28854436
    5. This review evaluates the current data concerning PAPP-A2 function, and particularly the effect of PAPP-A2 mutation on growth. PMID: 29238946
    6. These patients provide important insights into the regulation of longitudinal growth in humans, documenting the critical role of PAPP-A2 in releasing IGF-I from its binding proteins. PMID: 26902202
    7. Short-term treatment with progressive doses of rhIGF1 (recombinant human insulin-like growth factor-1) improved growth in two siblings with deficiency of PAPP-A2 (pregnancy-associated plasma protein-A2) [due to a homozygous loss-of-function frameshift mutation in exon 3 of the PAPP-A2 gene (p.D643fs25*)] that resulted in postnatal growth failure due to resulting decrease in IGF1 bioavailability. [CASE REPORT] PMID: 27648969
    8. in situ hybridization (ISH) and immunohistochemistry (IHC) were employed to examine the spatial and temporal expression of PAPPA2 in the human fetomaternal interface. PMID: 27525857
    9. PAPP-A2 is differentially expressed in different trophoblast populations and shows strong down regulation in the mid second trimester in chorionic villous samples. PMID: 26748159
    10. overexpression in Down syndrome from placental mRNA to maternal serum protein PMID: 25154785
    11. The association between this PAPPA2 single nucleotide polymorphism and developmental dysplasia of the hip was evaluated. PMID: 24672801
    12. The upregulation of PAPP-A2 observed in preeclampsia at term occurs early in pregnancy, before the symptoms develop. PMID: 24336677
    13. PAPPA2 may be upregulated in severe pre-eclampsia and, functionally, this may be mediated via increased placental hypoxia known to occur with this pregnancy disorder. PMID: 23484525
    14. The existence of this assay will enable an assessment of the biomarker potential of PAPP-A2 in pre-eclampsia as well as other clinical conditions. PMID: 23804707
    15. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip PMID: 22037112
    16. factors previously known to be highly expressed in preeclamptic placentae (PGE2 and TNF-alpha), contribute to the upregulation of PAPPA2. results are consistent with the hypothesis that PAPPA2 is upregulated as a consequence of placental pathology PMID: 21496272
    17. Circulating IGFBP-5 is proteolyzed by PAPP-A2 during pregnancy, resulting in increased IGF bioavailability, which may have important consequences for the development of the fetus and/or the well-being of the mother. PMID: 20103653
    18. Seven placental transcripts characterize HELLP-syndrome. PMID: 18374411
    19. PAPP-A2 in syncytiotrophoblast cells was dramatically increased in pre-eclampsia. Maternal serum concentrations of PAPP-A2 were also significantly elevated in pre-eclampsia as compared with uncomplicated pregnancy. PMID: 18805800
    20. Preeclampsia involves changes in the gene expression of PAPPA2 in placental cytotrophoblasts. PMID: 18818296
    21. PAPPA2 is expressed in the syncytiotrophoblast layer of human placental villi and is also detected in some invasive extravillous trophoblasts in the first trimester PMID: 19474058

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M43B family
  • 組織特異性：
    Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
  • 數據庫鏈接：

    HGNC: 14615

    KEGG: hsa:60676

    STRING: 9606.ENSP00000356634

    UniGene: Hs.187284



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