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  4. Human Neurotrophin 4,NT-4 ELISA KIT

Human Neurotrophin 4,NT-4 ELISA KIT

  • 中文名稱：
    人神經(jīng)營(yíng)養(yǎng)因子4(NT-4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04689h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)營(yíng)養(yǎng)因子4(NT-4)酶聯(lián)免疫試劑盒（CSB-E04689h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的NTF4含量。人神經(jīng)營(yíng)養(yǎng)因子4（NT-4）是一種神經(jīng)營(yíng)養(yǎng)因子，與外周感覺交感神經(jīng)元密切相關(guān)，參與神經(jīng)元生存和維持。其作用機(jī)制涉及與TrkB和p75NTR受體結(jié)合，調(diào)節(jié)神經(jīng)元生長(zhǎng)、發(fā)育和功能。NT-4在胰腺癌神經(jīng)浸潤(rùn)（PNI）中扮演重要角色，可能通過(guò)促進(jìn)癌細(xì)胞與神經(jīng)的交互作用，導(dǎo)致PNI發(fā)生。試劑盒檢測(cè)范圍為31.25 pg/ml-2000 pg/ml，科研人員可將其應(yīng)用于神經(jīng)發(fā)育機(jī)制研究、藥物干預(yù)效果評(píng)估或疾病模型中的NT - 4動(dòng)態(tài)變化分析，為探索神經(jīng)系統(tǒng)相關(guān)疾病的分子機(jī)制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名：
    GLC10 ELISA Kit; GLC1O ELISA Kit; Neurotrophic factor 4 ELISA Kit; Neurotrophic factor 5 ELISA Kit; Neurotrophin 4 ELISA Kit; Neurotrophin 4/5 ELISA Kit; Neurotrophin 5 (neurotrophin 4/5) ELISA Kit; Neurotrophin 5 ELISA Kit; Neurotrophin-4 ELISA Kit; Neurotrophin-5 ELISA Kit; Neutrophic factor 4 ELISA Kit; Neutrophic factor 5 ELISA Kit; NT 4 ELISA Kit; NT 4/5 ELISA Kit; NT 5 ELISA Kit; NT-4 ELISA Kit; NT-5 ELISA Kit; NT4 ELISA Kit; NT4/5 ELISA Kit; NT4P ELISA Kit; NT5 ELISA Kit; NTF4 ELISA Kit; NTF4_HUMAN ELISA Kit; NTF5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    31.25 pg/ml-2000 pg/ml.
  • 靈敏度：
    7.8 pg/ml.
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
     
  • 線性度：
     
  • 回收率：
     
  • 標(biāo)準(zhǔn)曲線：
     
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Target-derived survival factor for peripheral sensory sympathetic neurons.
  • 基因功能參考文獻(xiàn)：
    1. Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations. PMID: 24607879
    2. The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients. PMID: 22815630
    3. NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis. PMID: 22036954
    4. Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts. PMID: 21330466
    5. neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growth PMID: 21350004
    6. In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4. PMID: 20447632
    7. Identification of a single mutation in our study suggests that NTF4 mutations are a rare cause of primary open-angle glaucoma (0.6%, 95%CI 0.02%-3.16%) in Chinese people. PMID: 20806036
    8. present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
    9. Expression of human NTF4 was unchanged during gestation in the developping ovary. PMID: 20175187
    10. No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. PMID: 20215012
    11. A mechanism to understand the defect associated with variant BDNF and provide a framework two ligands for BDNF and NT-4. PMID: 15987945
    12. Re-expression of the p75NTR appears to partially reverse de-differentiation of prostate cancer cells by up-regulating the expression of CRABPI for localized sequestration of retinoids. PMID: 16316409
    13. Results revealed the expression of NT-4/5 mainly in oocytes and, in a minority of samples, also in the granulosa cells (GCs). PMID: 16648150
    14. These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseases PMID: 16648236
    15. Neurotrophin 4/5 plays a role in the proliferation and differentiation of periodontal ligament cells. PMID: 18980528
    16. Data show that the levels of NT-4/5 levels are significantly higher in bipolar disorder patients than in controlsNT-4/5. immunocontent alterations in bipolar disorder. PMID: 19081579
    17. NTF4 mutations impair neurotrophin-4 signaling in patients with primary open-angle glaucoma and lead to decreased activation of TrkB PMID: 19765683

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  • 相關(guān)疾?。?/div>
    Glaucoma 1, open angle, O (GLC1O)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    NGF-beta family
  • 組織特異性：
    Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8024

    OMIM: 162662

    KEGG: hsa:4909

    STRING: 9606.ENSP00000301411

    UniGene: Hs.266902



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