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中文名稱:人神經降壓素/神經調節素N (NTS) 酶聯免疫試劑盒
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貨號:CSB-E09144h
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規格:96T/48T
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價格:¥3200/¥2500
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其他:
產品詳情
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產品描述:人神經降壓素/神經調節素N (NTS) 酶聯免疫試劑盒(CSB-E09144h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的NTS含量。NTS即神經降壓素(Neurotensin),它是一種腦腸肽,分布于中樞神經系統和胃腸道。在研究機制方面,NTS通過與神經降壓素受體結合,參與調節多種生理過程,如痛覺感受、體溫調節、內分泌等,其在神經精神疾病及腫瘤等研究中受關注。試劑盒檢測范圍為15.6 pg/ml- 1000pg/ml,為神經生物學、消化系統疾病研究及藥物開發等領域提供可靠工具,支持科研人員探究NT在帕金森病、腸易激綜合征等疾病模型中的表達規律,或評估實驗干預對NT信號通路的影響。適用于批量樣本的高通量檢測,為體外實驗研究提供高效解決方案。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:Human proneurotensin ELISA Kit; Large neuromedin N ELISA Kit; Neuromedin N preproprotein ELISA Kit; Neurotensin/neuromedin N ELISA Kit; NEUT_HUMAN ELISA Kit; NMN 125 ELISA Kit; NmN ELISA Kit; NmN-125 ELISA Kit; NN ELISA Kit; NT ELISA Kit; NT/N ELISA Kit; NTRH ELISA Kit; NTS ELISA Kit; NTS1 ELISA Kit; Pro neurotensin/neuromedin ELISA Kit; Proneuromedin N mRNA ELISA Kit; Tail peptide ELISA Kit
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縮寫:NTS
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:15.6 pg/ml - 1000pg/ml
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靈敏度:3.9 pg/ml
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Neuroscience
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
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線性度:
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回收率:
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標準曲線:
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數據處理:
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貨期:3-5 working days
引用文獻
- Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer YM Tsai,Int. J. Mol. Sci,2020
- Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake Yongtao Xiao .et al,EBIOMEDICINE,2018
- Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients Ouyang Q et al,Mol Cancer,2015
相關產品
靶點詳情
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功能:Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
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基因功能參考文獻:
- In the elderly population, proneurotensin independently predicts development of cardiovascular diseases in both genders, whereas it only predicts diabetes in women. PMID: 29546332
- Neurotensin plasma values differentiate healthy people from patients suffering from colonic pathologies such as adenomatous polyps and adenocarcinoma. PMID: 28560510
- NTS may be an important stimulus to promote hepatocellular carcinoma invasion and metastasis both in vitro and in vivo. PMID: 27611941
- Higher concentrations of proneurotensin are associated with a greater risk of incident cardiovascular events in the community. This association did not vary according to sex, baseline low-density lipoprotein, or sortilin receptor 1 genotype. PMID: 27312221
- sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin binding site, and is a competitor of neurotensin PMID: 27666481
- children with untreated coeliac disease have elevated peripheral pro-NT levels compared with disease controls. Pro-NT levels also seem to reflect more severe forms of active coeliac disease, indicating a potential role of NT in small intestinal inflammation. PMID: 27612962
- findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment PMID: 27193687
- Although no measures for pain threshold, thermal instability or gastric motility were performed in our study participants, higher plasma NT levels were found in PWS children PMID: 25847417
- pretreatment of gastric cancer cells with NTR1 inhibitor SR48692 was shown to significantly inhibit the NT-mediated MMP-9 activity, cell invasion, and migration PMID: 25724188
- NTS/IL-8/CXCR1/STAT3 signaling is crucial for the maintenance of stem-like traits in glioblastoma stem cells . PMID: 25200966
- NTS/NTSR1 complex enhances breast tumor aggressiveness via EGFR/HER2/HER3 pathway. PMID: 25249538
- Neurotensin and its receptor NTSR1 causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib. PMID: 25249545
- indicate that neurotensin is a direct target of the Wnt/beta-catenin pathway and may be a mediator for neuroendocrine tumor cell growth PMID: 25098665
- The antimicrobial peptide neurotensin has activity against invasive microbes. PMID: 12074933
- Results show that both the neurotensin (NT) and the neurotensin 1 receptor hNTS1(321-344)fragment present a 3D structure in complex. PMID: 23140271
- NT production by keratinocytes may exert a paracrine effect on other skin cells, namely fibroblasts, macrophages, and dendritic cells for correct wound healing. PMID: 24198343
- These findings provide new insights into the potential therapeutic role of NT in chronic wounds, such as in DFU, characterized by a deficit in the migratory properties of cells and a chronic proinflammatory status. PMID: 24000330
- Neurotensin-mediated calcium signaling appears more sensitive to differentiation than ATP-mediated Ca(2+) signaling PMID: 23962427
- Nanoparticles exposing neurotensin tumor-specific drivers. PMID: 23436714
- Data indicate synchronous increase of neurotensin (NTS) and IL-8 in hepatocellular carcinoma (HCC) correlated with worse prognosis and shorten survival after surgery. PMID: 23418512
- Proneurotensin expression in the tumor tissues indicated that this precursor was produced by small cell lung carcinoma tumors and secreted into plasma as the tumors grew. PMID: 22825476
- a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
- NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells. PMID: 23109725
- Neurotensin secretion is regulated by PI3 kinase p110 alpha and protein kinase B signaling pathways. PMID: 22700584
- Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling. PMID: 22416137
- CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. PMID: 21994122
- Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. PMID: 21806946
- Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells. PMID: 19393580
- determined the status of ERalpha and ERbeta in the myometrium and leiomyomas, atypical leiomyomas and leiomyosarcomas, concomitantly with the expression of NTS/NTS receptor 1 in these tumors PMID: 21623207
- Human, pig, and frog NT and [Gln(4)]NT and [D-Tyr(11)]NT adsorbed to the silver surface via the tyrosine ring, the oxygen atom of the deprotonated phenol group of Tyr(11), and the -CH(2)- unit(s), most probably of Tyr(11), Arg(9), and/or Leu(13). PMID: 21542591
- study found that inhibition of mTORC1 signaling by rapamycin, torin1, and shRNA-mediated knockdown enhances NT secretion by increasing NT gene expression in the endocrine cell line BON PMID: 21508335
- Expression of neurotensin and ghrelin systems are markedly altered in the temporal lobe of Alzheimer's disease patients, which may contribute to the severe cognitive deficit observed in this pathology. PMID: 20858966
- Results indicate that the counteraction of neurotensin and neurotensin receptor subtype-1 regulates the genesis and development of pancreatic carcinomas. PMID: 21272935
- NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. PMID: 21233215
- IGF-1R activation represents a previously unrecognized key pathway involved in the mechanisms by which NT and NTR1 modulate colonic inflammation and inflammatory bowel disease. PMID: 21212273
- Data show that neurotensin- and NTSR1-positive mmunohistochemistry staining in 60.4% and 59.7% of lung adenocarcinomas, respectively. PMID: 20810387
- key regulatory elements in the promoter region that are involved in human NT/N (hNT/N) gene expression PMID: 21030593
- Neurotensin is increased in serum of young children with autistic disorder. PMID: 20731814
- The expression of NTS is identified as a prognostic marker in patients with malignant pleural mesothelioma. PMID: 19932148
- neurotensin /NTR1 signaling in pancreatic cancer cells seems to promote the induction of a metastatic phenotype, in contrast to its varying effects on tumor cell proliferation. PMID: 20138826
- The aim of this study was to provide an up-to-date review of the literature concerning the regulatory role of NT on the hypothalamic-anterior pituitary axons--REVIEW PMID: 19878995
- topography of its binding site to NT 1 receptor PMID: 11906607
- Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1. PMID: 11912133
- role in counteracting apoptosis in breast cancer cells PMID: 12150975
- Neurotensin expressing neurons develop earlier than vasoactive intestinal polypeptide, vasopressin, and neuropeptide Y expressing neurons in the suprachiasmatic nucleus. (neurotensin) PMID: 12531461
- neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression PMID: 14699144
- Analysis of the NTS genomic sequence revealed 2 intronic polymorphisms and 1 variant located in the 5' untranslated region (UTR). None of the observed variants co-segregated with RLS and no disease-associated polymorphisms were detected PMID: 14743366
- neurotensin secretion is mediated by protein kinase C-alpha/-delta and Rho/Rho kinase, and protein kinase D PMID: 15123666
- Transcription of NT in the mitochrondria of BON cells in response to pharmacologic manipulation. PMID: 15358593
- MARCKS-mediated neurotensin release occurs via protein kinase C-delta downstream of the Rho/ROK pathway PMID: 15623535
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亞細胞定位:Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.
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蛋白家族:Neurotensin family
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