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Human Myoglobin,MYO/MB ELISA Kit

  • 中文名稱:
    人肌紅蛋白(MYO/MB)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E05141h
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人肌紅蛋白(MYO/MB)酶聯(lián)免疫試劑盒(CSB-E05141h)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的MB含量。人肌紅蛋白(MYO/MB)是一種存在于肌肉細(xì)胞中的蛋白質(zhì),主要功能是儲(chǔ)存和運(yùn)輸氧氣。其研究機(jī)制涉及氧儲(chǔ)存、轉(zhuǎn)運(yùn)、清除自由基和調(diào)節(jié)一氧化氮水平等,對(duì)心肌和骨骼肌細(xì)胞的氧代謝至關(guān)重要。試劑盒檢測(cè)范圍為1.56 ng/mL-100 ng/mL,靈敏度為0.39 ng/mL。適用于基礎(chǔ)科研領(lǐng)域,如動(dòng)物模型中肌肉損傷的動(dòng)態(tài)評(píng)估、疾病機(jī)制研究中肌紅蛋白表達(dá)水平的分析,或藥物干預(yù)后肌肉修復(fù)效果的體外實(shí)驗(yàn)驗(yàn)證;可為心血管疾病、運(yùn)動(dòng)醫(yī)學(xué)及肌肉相關(guān)病理研究提供可靠的數(shù)據(jù)支持。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    MB ELISA Kit; MGC13548 ELISA Kit; MYG_HUMAN ELISA Kit; Myoglobin ELISA Kit
  • 縮寫:
    MB
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍:
    1.56 ng/mL-100 ng/mL
  • 靈敏度:
    0.39 ng/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Metabolism
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human MYO/MB in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:10 Average % 92  
    Range % 89-99  
    1:20 Average % 87  
    Range % 83-96  
    1:40 Average % 94  
    Range % 90-100  
    1:80 Average % 94  
    Range % 86-98  
  • 回收率:
    The recovery of human MYO/MB spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 91-99  
    EDTA plasma (n=4) 97 90-110  
                 
                 
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    100 2.175 2.211 2.193 2.107  
    50 1.613 1.656 1.635 1.549  
    25 1.024 1.004 1.014 0.928  
    12.5 0.571 0.584 0.578 0.492  
    6.25 0.312 0.308 0.310 0.224  
    3.12 0.188 0.195 0.192 0.106  
    1.56 0.129 0.125 0.127 0.041  
    0 0.085 0.087 0.086    
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展:
    MB是一種肌球蛋白結(jié)合蛋白,全名為肌紅蛋白結(jié)合蛋白。它主要在心肌細(xì)胞中發(fā)揮作用,參與心肌收縮和舒張。最近的研究表明,MB還可能參與神經(jīng)退行性疾病、肌肉疾病等多種疾病的發(fā)生和發(fā)展,具有一定的生物學(xué)意義和臨床價(jià)值。
  • 功能:
    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
  • 基因功能參考文獻(xiàn):
    1. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of Cardiac biomarkers . Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. PMID: 29857573
    2. Report morphology of myoglobin casts in renal biopsies with acute kidney injury. PMID: 27038680
    3. Myoglobin is associated with larger hematoma volume and growth after adjusting potential confounding factors in intracerebral hemorrhage. PMID: 27056440
    4. we found that the A79G polymorphism of the MB gene plays an important role in influencing the development of exercise-induced skeletal muscle damage. PMID: 27323063
    5. Electroanalysis of myoglobin as a marker of acute myocardial infarction by means of screenprinted electrodes modified with multiwalled carbon nanotubes and polymeric artificial antibodies is developed. Plastic antibodies to myoglobin (molecularly imprinted polymers, MIPs) based on o-phenylenediamine were produced by electropolymerization. Molecular imprinting technology in biosensor analysis was used. PMID: 27417724
    6. In the absence of Mb, the Y-shape structure remains intact. So, a weak electrochemical signal is observed. Upon addition of target, the DApt leave the CS and bind to Mb, leading to disassembly of Y-shape structure and following the addition of Exo I, a strong electrochemical signal could be recorded. PMID: 26894983
    7. analysis of myoglobin gene regulatory networks in breast and prostate cancer PMID: 26559958
    8. Data show that with the myoglobin (MYO) monoclonal antibody of high specificity and affinity, a one-step sandwich ELISA for detecting MYO has been established successfully, which provides a basis for the development of domestic ELISA kit. PMID: 26271987
    9. Misfolding and amyloid aggregation of apomyoglobin. PMID: 23839096
    10. A non-ischemic serum myoglobin release is rare, but could be associated in subgroups of patients. PMID: 25002394
    11. Data show that chimeric neuroglobin and myoglobin were generated by swapping a regulatory segment. PMID: 25452214
    12. Findings indicate that myoglobin (Mb) and neuroglobin (Ngb) can be expressed in nonmuscle and non-neural contexts. PMID: 24446190
    13. Analogous to breast cancer, MB expression in prostate cancer is associated with steroid hormone signaling and markers of hypoxia PMID: 25172328
    14. the novel cancer-associated MB splice variants exhibited increased expression in tumor cells subjected to experimental hypoxia; the novel gene regulatory mechanisms unveiled in this study support the idea of a non-canonical role of MB during carcinogenesis PMID: 24026678
    15. Blood myoglobin could serve as a valuable early predictor and marker of rhabdomyolysis and acute myoglobinuric kidney injury PMID: 23931877
    16. High myoglobin expression is associated with renal cell carcinoma. PMID: 24076247
    17. Our LFIA performance was additionally compared with electrochemiluminescence immunoassay (ECLI) detection for simultaneous determination of hs-cTnI and myoglobin in patients with suggestive of acute myocardial infarction . PMID: 23247055
    18. Hydrophobic effect drives oxygen uptake in myoglobin via histidine E7. PMID: 23297402
    19. MD simulations supported NMR results indicating interesting structural/dynamical differences in the average volume and occurrence of the main cavities lining Mb prosthetic group. PMID: 21782983
    20. The mitochondrion-impairing role of MB in hypoxic cancer cells is part of a novel tumor-suppressive function. PMID: 21930697
    21. overexpression in non-small cell lung cancer is associated with histological subtype and hypoxia PMID: 21601304
    22. may have potential significance in the prognostication of lung adenocarcinomas PMID: 21640426
    23. Apomyoglobin mutants with point mutations at val10 forms amyloid structures at permissive temperature. PMID: 21639835
    24. These results show that glutathione reduces hydrogen peroxide-induced protein decomposition due to reduction of the C110-thiyl radical in WTwild type human Mb by electron transfer. PMID: 21256983
    25. Water entry into the heme pockets of isolated hemoglobin subunits was detected by optical methods. PMID: 20668762
    26. Kinetics of interaction between apomyoglobin and phospholipid membrane PMID: 20873231
    27. Using a cardiovascular model suggest that myoglobin oxygen storage/transport becomes significant during systolic reduction of coronary blood flow rather than during diastole. PMID: 20124401
    28. 71% of tumours displayed Mb protein expression in significant correlation with a positive hormone receptor status and better prognosis. PMID: 20531416
    29. The Dimension Vista cTnI, CK-MB, MYO, NTproBNP, and hsCRP methods demonstrate acceptable performance characteristics for use as an aid in the diagnosis and risk assessment of patients presenting with suspected acute coronary syndromes. PMID: 19523464
    30. Screening of exon 2 of the myoglobin gene in high altitude Tibetans does not show novel polymorphism or selection for specific myoglobin alleles as a function of altitude of residence or hypoxic challenge. PMID: 12006163
    31. myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. PMID: 12745799
    32. It was concluded that myoglobin levels on admission and TnT at 2 h had the greatest diagnostic rate for myocardial infarction. PMID: 12760310
    33. Oxidative stress associated with myoglobin expression specifically in mitochondrial diseases. PMID: 14506721
    34. determination of myoglobin concentration and succinate dehydrogenase activity in serial sections indicate that myoglobin can lead to a substantial reduction (18-60%) of the extracellular oxygen tension required to prevent an anoxic core in muscle cells PMID: 15048578
    35. Quantitative test is useful for early diagnosis of acute myocardial infarct and as an indicator of its severity. PMID: 15226628
    36. Binding to blood fatty acid binding protein and may be a marker for cardiac damage in hemodialysis patients. PMID: 15226631
    37. heme rotates about the alpha-gamma axis of human myoglobin without leaving the protein cage PMID: 15485667
    38. energy analysis of myoglobin recognition of oxygen PMID: 15601759
    39. S-nitroso oxymyoglobin stores vasoactive nitric oxide PMID: 15644316
    40. iron mobilization and myoglobin down-modulation are elicited by enhanced erythropoiesis from elevated iron PMID: 17311997
    41. Data show plasma MG may be considered as a novel marker of muscle mass indicating best the mass of MG-rich type 1 and 2a fibers as well as VO(2)max as an important functional readout. PMID: 17605115
    42. analysis of covalent modification, unfolding, and aggregation of human holo-myoglobin induced by tyrosinase-generated quinones PMID: 17883274
    43. In this study, we showed for the first time the connection of ROR2 in Dupuytren's disease. ROR2 and myoglobin may play an important role in the pathophysiology of this disease PMID: 17996904
    44. Hypoxia reprograms calcium signaling and regulates myoglobin expression. PMID: 19005161
    45. myoglobin is expressed at high levels by human carcinoma cells PMID: 19541931
    46. Exposure of vascular smooth muscle (either in cell culture or intact vessels) to pathological nitric oxide (*NO) promotes an up-regulation of the Mb gene and protein, suggesting a feedback relationship between *NO and Mb. PMID: 19650765

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  • 蛋白家族:
    Globin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6915

    OMIM: 160000

    KEGG: hsa:4151

    STRING: 9606.ENSP00000352835

    UniGene: Hs.517586



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