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  4. Human Mucin-7,MUC7 ELISA Kit

Human Mucin-7,MUC7 ELISA Kit

  • 中文名稱：
    人粘蛋白/粘液素7(MUC7)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E11853h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人粘蛋白/粘液素7(MUC7)酶聯(lián)免疫試劑盒（CSB-E11853h）檢測血清、血漿、組織培養(yǎng)上清液、細(xì)胞裂解物,唾液樣本中的MUC7含量。MUC7是一種重要靶點。它是一種粘蛋白，在人體呼吸道、口腔等黏膜表面發(fā)揮保護(hù)作用。研究機制方面，圍繞其結(jié)構(gòu)與功能展開，探索其在疾病發(fā)生發(fā)展中的角色，如在呼吸道感染、口腔疾病中，MUC7可能通過影響病原體黏附等機制參與其中。試劑盒檢測范圍為18.75 ng/mL-1200 ng/mL，適用于科研領(lǐng)域探究口腔疾病、呼吸道炎癥、微生物互作等方向中粘蛋白的動態(tài)變化，為黏膜免疫機制研究、唾液成分分析及體外細(xì)胞模型分泌功能評估提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Apo MG2 ELISA Kit; Apo-MG2 ELISA Kit; DKFZp686J03256 ELISA Kit; FLJ27047 ELISA Kit; MG2 ELISA Kit; MGC34772 ELISA Kit; MUC 7 ELISA Kit; MUC-7 ELISA Kit; MUC7 ELISA Kit; MUC7_HUMAN ELISA Kit; Mucin 7 ELISA Kit; Mucin 7; salivary ELISA Kit; Mucin 7; secreted ELISA Kit; Mucin-7 ELISA Kit; Salivary mucin 7 ELISA Kit; Salivary mucin-7 ELISA Kit
  • 縮寫：
    MUC7
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, cell lysates,saliva
  • 檢測范圍：
    18.75 ng/mL-1200 ng/mL
  • 靈敏度：
    4.68 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MUC7 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 89  
    Range % 85-105  
    1:2 Average % 95  
    Range % 90-100  
    1:4 Average % 99  
    Range % 92-107  
    1:8 Average % 92  
    Range % 86-98  
  • 回收率：
    The recovery of human MUC7 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 89-103  
    EDTA plasma (n=4) 91 88-100  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    1200 2.052 1.952 2.002 1.902  
    600 1.325 1.376 1.351 1.251  
    300 0.876 0.845 0.861 0.761  
    150 0.529 0.525 0.527 0.427  
    75 0.348 0.357 0.353 0.253  
    37.5 0.263 0.274 0.269 0.169  
    18.75 0.185 0.174 0.180 0.080  
    0 0.102 0.097 0.100 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
  • 基因功能參考文獻(xiàn)：
    1. The genotypic polymorphisms of IL-1beta -511 and +3954, and of MUC7 VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1beta -511 may increase the risk of BMS by increasing psychological asthenia. PMID: 27246755
    2. High expression of MUC7 is associated with clear-cell renal cell carcinoma. PMID: 27683054
    3. A capsule-free mutant of S. pneumoniae TIGR4 binds to salivary proteins, most prominently to mucin MUC7, but that this binding was not mediated through PsrP or recognition of sialic acid. PMID: 26172471
    4. MUC7 glycosylation is altered in recurrent aphthous stomatitis. This may change the protective properties of this mucin against mucosal pathogens, which may effect this condition. PMID: 26051835
    5. Results identified a reduction in glycosylation of MUC7 in Sjogren's primarily due to the loss of the extended core 2 disialylated structure, with and without fucosylation and suggest that MUC7 O-glycan changes in Sjogren's Syndrome may alter the physical properties of saliva, leading to the symptom of dry mouth. PMID: 26631508
    6. The minimally invasive PTT procedure combined with Mucin 7 targeted GNPs is able to kill cancer cells and preserve healthy cells PMID: 25834826
    7. MUC7 is a salivary mucin with antimicrobial activity against bacteria and fungi. PMID: 12543672
    8. A significant increase in sulfation was identified in salivary MUC7 from rheumatoid arthritis patients. PMID: 23457413
    9. The study did not show a correlation between the MUC7 genotypes and caries. PMID: 22706105
    10. The present study did not disclose an association between MUC7*5/*6 and MUC7*6/*6 genotypes and gingival bleeding index. PMID: 23002673
    11. expression of different numbers of terminal repeats in this salivary mucin in the oral environment does not interfere with the etiopathogenesis of aggressive or chronic periodontitis PMID: 22167029
    12. MUC7 expression in ductal adenocarcinoma (DAC) and chronic pancreatitis was not statistically significant, but MUC7 could be considered as potential marker of malignant lesions, especially in pancreatic DAC, as it was positive in 73% of these cases. PMID: 21647207
    13. A novel MUC7*5-generated variable number of tandem repeat (VNTR) polymorphism decreases the likelihood of a diagnosis of asthma in an African American population. PMID: 19820409
    14. MUC5B and MUC7 from HIV patients, unlike the MUC5B and MUC7 from HIV negative individuals, did not inhibit HIV-1 activity. PMID: 20946627
    15. Structure and biosynthesis of human salivary mucins. PMID: 11996097
    16. Level of MG2 is lower in saliva of subjects with dental disease PMID: 12459324
    17. binds to Streptococcus mutans alpha-enolase [MG2] PMID: 15501816
    18. reported as new substrate for StcE protease of Escherichia coli O157-H7 in HEp-2 cells PMID: 15731026
    19. Interactions between mucin and non-mucin proteins in saliva could protect complex partners from proteolysis PMID: 16203048
    20. When the cells were treated with a panel of cytokines, epidermal growth factor, or a bacterial product (Pseudomonas aeruginosa lipopolysaccharide [LPS]), MUC7 transcripts and glycoprotein products were increased 1.7- to 3.2-fold. PMID: 16514118
    21. Data demonstrate that TNF-alpha activates MUC7 transcription via NF-kappaB signaling pathway. PMID: 16778149

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  • 相關(guān)疾病：
    Asthma (ASTHMA)
  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7518

    OMIM: 158375

    KEGG: hsa:4589

    STRING: 9606.ENSP00000302021

    UniGene: Hs.631946



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