在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human Matrix metalloproteinase-20(MMP20) ELISA kit

Human Matrix metalloproteinase-20(MMP20) ELISA kit

  • 中文名稱：
    人基質金屬蛋白酶-20(MMP20)酶聯免疫試劑盒
  • 貨號：
    CSB-EL014667HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人基質金屬蛋白酶-20(MMP20)酶聯免疫試劑盒（CSB-EL014667HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的MMP20含量。MMP20 即基質金屬蛋白酶 20，在牙釉質發育中起關鍵作用。其研究機制主要聚焦于參與牙釉質蛋白水解、調控釉質礦化過程等方面。對它的深入研究有助于理解牙釉質形成機理，為牙釉質發育異常相關疾病的診治提供思路。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，牙齒發育相關疾病機制研究、口腔組織工程及病理過程分析、牙釉質發育調控、口腔疾病模型構建、生物材料降解評估、細胞生物學、組織工程及疾病機制等領域的科研需求本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    AI2A2 ELISA Kit; Enamel metalloproteinase ELISA Kit; Enamelysin ELISA Kit; Matrix metalloproteinase 20 ELISA Kit; Matrix metalloproteinase-20 ELISA Kit; MMP 20 ELISA Kit; MMP-20 ELISA Kit; MMP20 ELISA Kit; MMP20_HUMAN ELISA Kit
  • 縮寫：
    MMP20
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human MMP20 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 89
    Range % 85-93
    1:2 Average % 100
    Range % 95-105
    1:4 Average % 86
    Range % 83-89
    1:8 Average % 97
    Range % 92-101
  • 回收率：
    The recovery of human MMP20 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 88 86-90
    EDTA plasma (n=4) 101 97-104
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.303 2.204 2.254 2.101
    10 1.915 1.964 1.940 1.787
    5 1.636 1.530 1.583 1.430
    2.5 1.201 1.301 1.251 1.098
    1.25 0.821 0.835 0.828 0.675
    0.625 0.512 0.501 0.507 0.354
    0.312 0.352 0.368 0.360 0.207
    0 0.154 0.152 0.153 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
  • 基因功能參考文獻：
    1. The levels of MMP20 silencing-induced downregulation differed amongst CSC markers, with ABCG2 and CD44 showing more pronounced downregulations. PMID: 30002682
    2. common variants at 11q22.2 within MMP20 associate with neuroblastoma cases harboring 11q deletion (rs10895322) PMID: 28924153
    3. The article data showed that MMP20 rs1784418 C>T (Matrix metalloproteinase 20) appears to protect against dental caries, but its effects are likely to be more marked in certain populations. PMID: 27992873
    4. DSPP-MMP20 pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons. PMID: 27666430
    5. Levels of matrix metalloproteinases MMP-19 and MMP-20 expression are significantly increased in pancreatic ductal adenocarcinoma (PDAC). PMID: 26692439
    6. The expression of MMP20 was lower in calcifying cystic odontogenic tumor when compared to all tumors and cysts. PMID: 26558991
    7. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD. PMID: 26337002
    8. Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function. PMID: 26124219
    9. expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues PMID: 25805840
    10. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression. PMID: 23241590
    11. Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation. PMID: 23953525
    12. mineralized content slightly decreased; magnesium substituting for calcium in crystal. anomalies affected enamel with minimal interrod enamel; apatite crystals perpendicular to enamel prisms, suggesting possible new role for MMP20 in enamel formation. PMID: 23625376
    13. amelogenesis imperfecta-causing mutations were identified in three of the probands: 2)a novel missense transition mutation in both MMP20 alleles (g.15390A>G; c.611A>G; p.His204Arg) that substituted arginine for histidine. PMID: 23355523
    14. Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits. PMID: 22330321
    15. hypocalcified amelogenesis imperfecta, Witkop type III, was unrelated to previously described mutations in the ENAM or MMP-20 genes PMID: 21504268
    16. MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium. PMID: 21466263
    17. Associations between tooth agenesis and MMP1 (p=0.007), and MMP20 (p=0.03) were found in Brazilian families. MMP20 continued to be associated with tooth agenesis (p=0.01). Mmp20 was not expressed during the initial stages of tooth development. PMID: 21144496
    18. Enamelysin and collagen XVIII were co-localized in the developing enamel matrix and stratum intermedium and in the enamel-like tumor matrix of odontogenic tumors. PMID: 15296943
    19. A mutation in the MMP-20 gene has been identified and associated with amelogenesis imperfecta. PMID: 15744043
    20. c-Jun is a key regulatory element for MMP-20 expression PMID: 17611094
    21. Binding of the P41T mutant amelogenin for matrix metalloproteinase 20 was significantly lower than that of wild-type amelogenin. PMID: 18434575
    22. A total of 463 individuals from 54 families were evaluated and mutations in the AMEL, ENAM and KLK4 genes were identified. PMID: 18714142
    23. were able to find SNPs in the matrix metallopeptidase gene MMP20(GeneID 9313) that are significantly associated with kidney aging. PMID: 19834535
    24. In a family with a hypomaturation-type enamel defect, mutational and haplotype analyses revealed an amelogenesis imperfecta-causing point mutation in exon 6 of MMP20 that results in a single amino acid substitution in the hemopexin domain. PMID: 19966041

    顯示更多

    收起更多

  • 相關疾病：
    Amelogenesis imperfecta, hypomaturation type, 2A2 (AI2A2)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 組織特異性：
    Expressed specifically in the enamel organ.
  • 數據庫鏈接：

    HGNC: 7167

    OMIM: 604629

    KEGG: hsa:9313

    STRING: 9606.ENSP00000260228

    UniGene: Hs.591946



主站蜘蛛池模板： 欧美肥婆姓交大片| 日日摸日日碰夜夜爽无| 亚洲日本一区二区三区在线| 精品深夜av无码一区二区| 五十路亲子中出在线观看| 一本大道久久香蕉成人网| 亚洲国产成人精品无码区一本 | 国产精品久久无码一区| 大香伊蕉在人线国产免费| 亚洲精品欧美综合四区| 久久亚洲欧美国产精品| 色欲国产麻豆一精品一av一免费| 国产精品免费一区二区三区四区| 日韩精品一区二区三区影院| 乱无码伦视频在线观看| 午夜精品久久久久久久99老熟妇| 久久无码人妻丰满熟妇区毛片 | 九色精品国产成人综合网站| 中文字幕av无码专区第一页| 天天躁日日躁狠狠躁av麻豆| 国产精品美脚玉足脚交欧美| 综合久久—本道中文字幕| 国产精品白丝av网站在线观看| 日韩av无码精品人妻系列| 国产亚洲高清国产拍精品| 青青久久成人免费影院| 国产交换配乱婬视频| 美女内射毛片在线看免费人动物| 欧美人与动人物牲交免费观看久久| 狠狠cao2020高清视频| 久久不见久久见免费影院视频| 中文字幕人成无码人妻综合社区| 国产成人av一区二区三区在线 | 亚洲人成电影在线播放| 人妻avav中文系列久久| 6080亚洲人久久精品| 成人av无码一区二区三区| 成年午夜性影院免费观看| 中国熟妇内谢69xxxxx| 人妻无码中文久久久久专区| 国产亚洲欧美日韩夜色凹凸成人|