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Human Matrin-3(MATR3) ELISA kit

  • 中文名稱:
    人基質蛋白-3(MATR3)酶聯免疫試劑盒
  • 貨號:
    CSB-EL013525HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人基質蛋白-3(MATR3)酶聯免疫試劑盒(CSB-EL013525HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿,組織勻漿、細胞裂解物樣本中的MATR3含量。MATR3是一個值得關注的靶點。它在細胞生理活動中有重要作用。目前研究聚焦于其在疾病發生發展中的機制,如參與調節基因表達、信號傳導等過程,對其深入研究有助于揭示相關疾病發病機理,為開發針對性治療策略提供依據。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL,適用于基礎科研領域,如探究MATR3在疾病模型中的表達動態、細胞應激條件下的調控機制,或結合多組學分析揭示其在RNA代謝相關通路中的分子功能。試劑盒兼容多種生物樣本類型,可滿足體外培養細胞、動物組織及體液樣本的檢測需求,操作簡便且重復性良好,為分子生物學、細胞生物學及疾病機制研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    ALS21 ELISA Kit; KIAA0723 ELISA Kit; Matr3 ELISA Kit; MATR3_HUMAN ELISA Kit; Matrin-3 ELISA Kit; Matrin3 ELISA Kit; MPD2 ELISA Kit; VCPDM ELISA Kit; Vocal cord and pharyngeal weakness with distal myopathy ELISA Kit
  • 縮寫:
    MATR3
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma,tissue homogenates, cell lysates
  • 檢測范圍:
    23.5 pg/mL-1500 pg/mL
  • 靈敏度:
    5.8 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Epigenetics and Nuclear Signaling
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of human MATR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:1

    Average %

    92

    Range %

    85-99

    1:2

    Average %

    96

    Range %

    91-100

    1:4

    Average %

    91

    Range %

    84-97

    1:8

    Average %

    93

    Range %

    86-98

  • 回收率:

    The recovery of human MATR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    92

    87-98

    EDTA plasma (n=4)

    97

    91-103

  • 標準曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    1500

    2.724

    2.634

    2.679

    2.555

    750

    2.055

    2.167

    2.111

    1.987

    375

    1.264

    1.328

    1.296

    1.172

    187.5

    0.736

    0.729

    0.733

    0.609

    94

    0.371

    0.381

    0.376

    0.252

    47

    0.243

    0.253

    0.248

    0.124

    23.5

    0.175

    0.184

    0.180

    0.056

    0

    0.123

    0.125

    0.124

     

  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins.
  • 基因功能參考文獻:
    1. Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3. PMID: 27731383
    2. Using a novel RNA pulldown approach that utilized endogenous S1-tagged PINCR (a p53-regulated long noncoding RNA), the authors show that PINCR associates with the enhancer region of these genes by binding to RNA-binding protein Matrin 3 that, in turn, associates with p53. PMID: 28580901
    3. Matrin3 physically interacts with intronic pyrimidine-rich sequences and controls alternative splicing. PMID: 28695676
    4. It may not be a common genetic factor in Chinese amyotrophic lateral sclerosis patients. PMID: 26708275
    5. Its mutations strengthens the role of RNA metabolism in amyotrophic lateral sclerosis etiology. PMID: 26493020
    6. A missense mutation in MATR3 was identified in myopathy patients undergoing a needle electromyography. PMID: 26899464
    7. Our findings indicate that mutations in Matrin 3 that are associated with ALS and myopathy do not dramatically alter the normal localization of the protein or readily induce inclusion formation. PMID: 26528920
    8. Three-dimensional mapping of the lamin A-matrin-3 interface showed that the LMNA truncating mutation Delta303, which lacks the matrin-3 binding domain, was associated with an increased distance between lamin A and matrin-3. PMID: 25948554
    9. Suppressing Matrin 3 powers a heightened and broader ZAP restriction of HIV-1 gene expression. PMID: 26129669
    10. MATR3 mutation is identified to be a possible cause of amyotrophic lateral sclerosis. PMID: 25771394
    11. No mutations were identified, indicating that MATR3 mutations are not a common cause of Amyotrophic lateral sclerosis in Australian familial cases with predominately European ancestry PMID: 25523636
    12. MATR3 gene disruption is associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. PMID: 25574029
    13. Mutations in MATR3 are rare in French familial ALS and ALS with FTLD patients. PMID: 25158920
    14. This study shows a high risk of abnormal respiratory function with progressive worsening in MATR3 myopathy. PMID: 25677933
    15. Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB. PMID: 25599992
    16. the pY RNA1-s2/Matr3 interaction could play a role in vision PMID: 24558381
    17. Sixteen patients from 6 families with late onset distal myopathy associated with the p.S85C MATR3 mutation were characterized. PMID: 25154462
    18. This study identified mutations in MATR3 in ALS kindreds. also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. PMID: 24686783
    19. Data suggest that the cellular level of MATR3, known to be highly regulated, modulates the stability of a group of gene transcripts. PMID: 21858232
    20. Rev needs MATR3 to promote the cytoplasmic accumulation and translation of unspliced RRE-containing mRNA. PMID: 21771348
    21. MATR3 binds viral RNA and is required for the Rev/RRE mediated nuclear export of unspliced HIV-1 RNAs. PMID: 21771346
    22. Matrin 3 binds Rev RNA to stabilize HIV-1 transcripts leading to increased cytoplasmic expression. PMID: 21771347
    23. MATR3 to be a novel ATM target in response to DNA damage. PMID: 20421735
    24. matrin 3 plays a significant role in controlling cell growth and proliferation PMID: 21182838
    25. study of the association of matr3 with chromosome territories and identification of potential interacting proteins PMID: 19562669
    26. Data show that the nuclear matrix protein matrin 3, cytoskeletal motor protein HMP, and the circadian clock protein lark were significantly decreased in fetal Down syndrome brain. PMID: 12469345
    27. These results suggest that the functions of matrin 3 could be regulated by both Ca(2+)-dependent interaction with calmodulin and caspase-mediated cleavage. PMID: 17658460
    28. the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1gamma, RNA polymerase II, matrin 3, and SAF-A sites PMID: 18618731
    29. nonconservative S85C missense mutation in vocal cord and pharyngeal weakness with distal myopathy PMID: 19344878

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  • 相關疾病:
    Amyotrophic lateral sclerosis 21 (ALS21)
  • 亞細胞定位:
    Nucleus matrix.
  • 數據庫鏈接:

    HGNC: 6912

    OMIM: 164015

    KEGG: hsa:9782

    STRING: 9606.ENSP00000354346

    UniGene: Hs.268939



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