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  4. Human Leukocyte immunoglobulin-like receptor subfamily A member 3(LILRA3) ELISA kit

Human Leukocyte immunoglobulin-like receptor subfamily A member 3(LILRA3) ELISA kit

  • 中文名稱：
    人白細胞免疫球蛋白樣受體亞家族A成員3(LILRA3)酶聯免疫試劑盒
  • 貨號：
    CSB-EL012935HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人白細胞免疫球蛋白樣受體亞家族A成員3(LILRA3)酶聯免疫試劑盒（CSB-EL012935HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的LILRA3含量。LILRA3是LILR家族成員，主要在單核細胞中表達，能識別MHC-I類分子及其同源物，通過影響免疫受體信號傳導，在天然免疫和獲得性免疫中發揮重要作用。其異常表達與多種疾病如類風濕關節炎、系統性紅斑狼瘡等密切相關，成為潛在的治療靶點。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，可支持科研人員探索LILRA3在免疫系統功能研究、疾病模型建立或生物標志物篩選中的應用；適用于體外實驗中對體液或組織樣本的LILRA3動態變化分析，為免疫相關機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    CD 85E ELISA Kit; CD85 antigen-like family member E ELISA Kit; CD85e ELISA Kit; CD85e antigen ELISA Kit; e3 ELISA Kit; HM 31 ELISA Kit; HM 43 ELISA Kit; HM31 ELISA Kit; HM43 ELISA Kit; ILT 6 ELISA Kit; ILT-6 ELISA Kit; ILT6 ELISA Kit; Immunoglobulin like transcript 6 ELISA Kit; Immunoglobulin-like transcript 6 ELISA Kit; Leucocyte immunoglobulin like receptor ELISA Kit; Leukocyte immunoglobulin like receptor 4 ELISA Kit; Leukocyte immunoglobulin like receptor A3 ELISA Kit; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3 ELISA Kit; Leukocyte immunoglobulin like receptor subfamily A member 3 ELISA Kit; Leukocyte immunoglobulin-like receptor 4 ELISA Kit; Leukocyte immunoglobulin-like receptor subfamily A member 3 ELISA Kit; LILRA 3 ELISA Kit; LILRA3 ELISA Kit; LIR 4 ELISA Kit; LIR-4 ELISA Kit; LIR4 ELISA Kit; LIRA3_HUMAN ELISA Kit; Monocyte inhibitory receptor HM43/HM31 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LILRA3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %87
    Range %80-94
    1:2Average %95
    Range %91-103
    1:4Average %102
    Range %96-108
    1:8Average %95
    Range %88-100
  • 回收率：
    The recovery of human LILRA3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9789-104
    EDTA plasma (n=4)9690-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.197 2.099 2.148 2.056
    51.349 1.425 1.387 1.295
    2.50.904 0.926 0.915 0.823
    1.250.577 0.603 0.590 0.498
    0.6250.410 0.404 0.407 0.315
    0.3120.255 0.254 0.255 0.163
    0.1560.178 0.174 0.176 0.084
    00.092 0.091 0.092 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
  • 基因功能參考文獻：
    1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
    2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
    3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
    4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
    5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
    6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
    7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
    8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
    9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
    10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
    11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
    12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
    13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
    14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
    15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
    16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
    17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
    18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
    19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
  • 數據庫鏈接：

    HGNC: 6604

    OMIM: 604818

    KEGG: hsa:11026

    STRING: 9606.ENSP00000251390

    UniGene: Hs.113277



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