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  4. Human L-lactate dehydrogenase B chain(LDHB) ELISA kit

Human L-lactate dehydrogenase B chain(LDHB) ELISA kit

  • 中文名稱：
    人L乳酸脫氫酶B鏈(LDHB)酶聯免疫試劑盒
  • 貨號：
    CSB-EL012841HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人L乳酸脫氫酶B鏈(LDHB)酶聯免疫試劑盒（CSB-EL012841HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、腦脊液（CSF）、尿液.樣本中的LDHB含量。LDHB即乳酸脫氫酶B，是乳酸脫氫酶的亞基之一。它參與糖酵解和乳酸代謝過程。研究發現其在多種腫瘤中表達異常，可能通過調節細胞代謝微環境、影響腫瘤細胞增殖凋亡等機制，在腫瘤發生發展中發揮作用，是潛在的腫瘤治療靶點。試劑盒檢測范圍為23.5 mU/mL-1500 mU/mL，該產品適用于體外科研實驗中多種生物樣本的LDHB活性檢測，可服務于細胞代謝研究、疾病模型能量通路分析、腫瘤微環境評估等基礎研究領域。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Epididymis secretory protein Li 281 ELISA Kit; HEL S 281 ELISA Kit; L lactate dehydrogenase B chain ELISA Kit; L-lactate dehydrogenase B chain ELISA Kit; Lactate Dehydrogenase B ELISA Kit; Lactate dehydrogenase H chain ELISA Kit; LDH B ELISA Kit; LDH H ELISA Kit; LDH heart subunit ELISA Kit; LDH-B ELISA Kit; LDH-H ELISA Kit; LDHB ELISA Kit; LDHB_HUMAN ELISA Kit; LDHBD ELISA Kit; LDHH ELISA Kit; Renal carcinoma antigen NY REN 46 ELISA Kit; Renal carcinoma antigen NY-REN-46 ELISA Kit; TRG-5 ELISA Kit; TRG5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cerebrospinal fluid (CSF), urine.
  • 檢測范圍：
    23.5 mU/mL-1500 mU/mL
  • 靈敏度：
    5.8 mU/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LDHB in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 89    
    Range % 84-93    
    1:2 Average % 100    
    Range % 97-103    
    1:4 Average % 87    
    Range % 84-90    
    1:8 Average % 102    
    Range % 98-106    
  • 回收率：
    The recovery of human LDHB spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 103 100-106    
    EDTA plasma (n=4) 89 85-92    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    mU/ml OD1 OD2 Average Corrected    
    1500 2.184 2.203 2.194 2.038    
    750 1.706 1.697 1.702 1.546    
    375 1.215 1.241 1.228 1.072    
    187.5 0.757 0.738 0.748 0.592    
    94 0.442 0.468 0.455 0.299    
    47 0.319 0.298 0.309 0.153    
    23.5 0.244 0.231 0.238 0.082    
    0 0.159 0.153 0.156 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. High LDHB expression is significantly associated with the level of serum LDH and better clinical outcomes in lung squamous cell carcinoma PMID: 28756978
    2. this study shows that low base line lactate dehydrogenase is linked with a better tumor response, and that prolonged overall survival and progression-free survival are observed for patients under ipilimumab treatment with no increase in lactate dehydrogenase PMID: 27485076
    3. our study examines the inclusion of salivary LDH as potential diagnostic parameter and therapeutic index in Oral squamous cell carcinoma PMID: 26577856
    4. addition of exogenous lactic acid to growth media was sufficient to induce cell death that could be inhibited by the expression of LDHB. the results suggest that lactate dehydrogenase is a general suppressor of programmed cell death in yeast. PMID: 26032856
    5. The aim of this study was to demonstrate the effects of 6-week low-intensity training on changes in indicators of aerobic capacity and on HSPA1A, HSPB1, and LDHb expression in white blood cells in high level rowers. PMID: 26214432
    6. Lactate dehydrogenase B is associated with the response to neoadjuvant chemotherapy in oral squamous cell carcinoma. PMID: 25973606
    7. The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit, into peroxisomes. PMID: 25247702
    8. We were able to provide evidence that methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker PMID: 24708595
    9. This meta-analysis shows that high serum LDH level is obviously associated with lower overall survival rate in patients with osteosarcoma, and it is an effective biomarker of prognosis. PMID: 24682390
    10. These observations support prospective clinical evaluation of LDHB as a predictive marker of response for patients with breast cancer receiving neoadjuvant chemotherapy. PMID: 23697991
    11. This study identifies LDHB as a regulator of cell proliferation in a subset of lung adenocarcinoma and may provide a novel therapeutic approach for treating lung cancer PMID: 23224736
    12. LDH concentrations in nasopharyngeal secretions are positively associated with acute otitis media risk. PMID: 23202721
    13. Loss of LDH-B expression is an early and frequent event in human breast cancer occurring due to promoter methylation, and is likely to contribute to an enhanced glycolysis of cancer cells under hypoxia. PMID: 23437403
    14. ata indicate that serum lactic dehydrogenase (S-LDH) appears to be a significant independent prognostic index in patients with metastatic nasopharyngeal carcinoma (NPC). PMID: 23266049
    15. Patients with severe vaso-occlusive crisis were more frequently males, who also had higher white blood cell (WBC) count, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels. PMID: 22892192
    16. Data reveal that LDHB is upregulated and required only in certain cancer genotypes. PMID: 23139210
    17. results indicate that histone deacetylase inhibitors upregulate miRNAs, at least some of which act as tumor suppressors. lactate dehydrogenase B, which is regulated by the tumor suppressive miR-375, may therefore act as an oncogene in esophageal squamous cell carcinoma. PMID: 22752059
    18. Serum lactate dehydrogenase is a prognostic and predictive biomarker for survival benefit conferred by TORC1 inhibition in poor-risk renal cell carcinoma. PMID: 22891270
    19. Data indicate that serum lactate dehydrogenase (LDH) seemed able to predict clinical outcome for hepatocellular carcinoma (HCC) patients undergoing hepatocellular carcinoma (HCC). PMID: 22461886
    20. The significant elevation in serum CK [creatine kinase ]and LDH [L-Lactate Dehydrogenase ] activities indicates that these can be used as parameters for screening hypothyroid patients but not hyperthyroid patients. PMID: 22248949
    21. results confirmed the prognostic roles of LDH-B in urinary bladder urothelial carcinoma. PMID: 22027740
    22. Results suggest that lactate dehydrogenase B suppression plays an important role in triggering or maintaining the mitochondrial defects and then contributes to cancer cell invasiveness by inducing claudin-1 protein. PMID: 21356207
    23. Elevated serum LDH isoenzymes and AST indicate a disturbance (of uncertain clinical significance) within multiple extraosseous tissues when there is CLCN7 deficiency. PMID: 20499337
    24. findings offer proof of concept for targeting LDHB as a therapeutic strategy in cancers driven by aberrant activation of the RTK-PI3K-AKT-mTOR signaling cascade PMID: 21199794
    25. S100B and LDH are not expressed in sentinel node progression of melanoma PMID: 20592382
    26. LDHB was elevated in idiopathic myelofibrosis. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
    27. MYC, LDHB, and CCNB1 may have roles in progression of medulloblastoma PMID: 18593994

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  • 相關疾病：
    Lactate dehydrogenase B deficiency (LDHBD)
  • 亞細胞定位：
    Cytoplasm. Mitochondrion inner membrane; Peripheral membrane protein.
  • 蛋白家族：
    LDH/MDH superfamily, LDH family
  • 數據庫鏈接：

    HGNC: 6541

    OMIM: 150100

    KEGG: hsa:3945

    STRING: 9606.ENSP00000229319

    UniGene: Hs.446149



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