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中文名稱:人犬尿氨酸(KYN)酶聯免疫試劑盒
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貨號:CSB-E13659h
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規格:96T/48T
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價格:¥3600/¥2500
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其他:
產品詳情
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產品描述:人犬尿氨酸(KYN)酶聯免疫試劑盒(CSB-E13659h)為競爭法ELISA試劑盒,定量檢測血清、尿液、組織勻漿樣本中的KYN含量。試劑盒檢測范圍為7.8 pmol/ml-500 pmol/ml,產品適用于科研場景中KYN代謝機制研究、疾病模型評估及藥物開發過程中的生物標志物檢測,例如探索神經系統疾病動物模型的代謝變化或免疫調節藥物對色氨酸代謝通路的影響。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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縮寫:KYN
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, urine, tissue homogenates
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檢測范圍:7.8 pmol/ml-500 pmol/ml.
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靈敏度:3.9 pmol/ml.
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Metabolism
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測定原理:quantitative
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測定方法:Competitive
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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線性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human KYN in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
Sample
Serum(n=4)
1:1
Average %
95
Range %
90-99
1:2
Average %
87
Range %
84-90
1:4
Average %
92
Range %
88-96
1:8
Average %
97
Range %
95-99
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回收率:
The recovery of human KYN spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type
Average % Recovery
Range
Serum (n=5)
94
90-98
EDTA plasma (n=4)
92
87-96
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標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pmol/ml
OD1
OD2
Average
500
0.200
0.202
0.201
250
0.318
0.338
0.328
125
0.498
0.470
0.484
62.5
0.685
0.664
0.675
31.2
1.036
1.016
1.026
15.6
1.468
1.404
1.436
7.8
1.533
1.657
1.595
0
1.710
1.723
1.717
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數據處理:
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貨期:3-5 working days
引用文獻
- IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment Z Wu, H Wang, Z Zheng, Y Lin, L Bian, H Geng,Journal of Translational Medicine,2025
- TDO2 promotes bladder cancer progression via AhR-mediated SPARC/FILIP1L signaling X Ding,Biochemical pharmacology,2024
- Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: Involvement of gut‐brain axis S Saleh‐Ghadimi,Journal of the science of food and agriculture,2023
- MUC1 Expression Affects the Immunoflogosis in Renal Cell Carcinoma Microenvironment through Complement System Activation and Immune Infiltrate Modulation G Lucarelli,International journal of molecular sciences,2023
- Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC Y Yang,International journal of oncology,2022
- Tryptophan 2, 3-dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells Yuemei Zhao,Molecular Medicine Reports,2021
- Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial Asma Kazemi.et al,clinical nutrition,2018
- A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: Targeting the hypothalamic?pituitary?adrenal axis and immune system Farhangi MA.et al,Clin Nutr,2017
- Lung Cancer Associated Fibroblast-Mediated Cancer Progression and Immune Inhibition Through TDO2/Kynurenine Loop Kuo P L.et al,Am J Respir Crit Care Med,2016
- Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis Hsu YL.et al,Oncotarget.,2016
- Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis Yang TH. et al,Arthritis Res Ther,2015
- The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers Mohammadi AA et al,Nutr Neurosci,2015
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