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  4. Human Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

Human Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

  • 中文名稱：
    人白介素-22受體α-2亞基(IL22RA2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011637HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人白介素-22受體α-2亞基(IL22RA2)酶聯(lián)免疫試劑盒（CSB-EL011637HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL22RA2含量。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于基礎(chǔ)科研中探索IL22RA2在炎癥性疾病模型、免疫調(diào)節(jié)機制或特定組織微環(huán)境中的動態(tài)變化，為體外實驗提供定量數(shù)據(jù)支持。能夠滿足細胞因子信號通路研究、藥物干預(yù)效果評估等多元化科研需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    IL 22BP ELISA Kit; IL 22RA2 ELISA Kit; IL22RA2 ELISA Kit; Class II cytokine receptor ELISA Kit; CRF2 10 ELISA Kit; CRF2 S1 ELISA Kit; CRF2-10 ELISA Kit; CRF2-S1 ELISA Kit; CRF2X ELISA Kit; Cytokine receptor class II member 10 ELISA Kit; Cytokine receptor class-II member 10 ELISA Kit; Cytokine receptor family 2 member 10 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; Cytokine receptor family type 2 soluble 1 ELISA Kit; I22R2_HUMAN ELISA Kit; IL 22 receptor subunit alpha 2 ELISA Kit; IL 22R alpha 2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22BP ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; IL22 RA2 ELISA Kit; IL22BP ELISA Kit; IL22R alpha 2 ELISA Kit; Il22ra2 ELISA Kit; Interleukin 22 binding protein ELISA Kit; Interleukin 22 Receptor alpha 2 ELISA Kit; Interleukin-22 receptor subunit alpha-2 ELISA Kit; Interleukin-22-binding protein ELISA Kit; MGC150509 ELISA Kit; MGC150510 ELISA Kit; soluble 1 ELISA Kit; ZcytoR16 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 94
    Range % 87-98
    1:2 Average % 107
    Range % 103-112
    1:4 Average % 91
    Range % 85-97
    1:8 Average % 92
    Range % 88-96
  • 回收率：
    The recovery of human IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 102 98-105
    EDTA plasma (n=4) 98 93-104
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 1.927 2.057 1.992 1.889
    1000 1.342 1.460 1.401 1.298
    500 0.922 0.965 0.944 0.841
    250 0.651 0.663 0.657 0.554
    125 0.432 0.412 0.422 0.319
    62.5 0.254 0.269 0.262 0.159
    31.25 0.208 0.201 0.205 0.102
    0 0.104 0.102 0.103 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.
  • 基因功能參考文獻：
    1. expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin PMID: 27676439
    2. suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID: 27678220
    3. thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP PMID: 28356382
    4. The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. PMID: 26931784
    5. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID: 26329427
    6. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID: 21041731
    7. The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID: 18675824
    8. Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. PMID: 19193995
    9. Polymorphisms in IL22RA1 are associated with severe CRS. PMID: 19393422

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 組織特異性：
    Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14901

    OMIM: 606648

    KEGG: hsa:116379

    STRING: 9606.ENSP00000296980

    UniGene: Hs.126891



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