在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Integrin alpha-1(ITGA1) ELISA kit

  • 中文名稱:
    人整合素α-1(ITGA1)酶聯免疫試劑盒
  • 貨號:
    CSB-EL011861HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人整合素α-1(ITGA1)酶聯免疫試劑盒(CSB-EL011861HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的ITGA1含量。ITGA1是一種細胞表面受體,編碼整合素受體的alpha 1亞基,與beta 1亞基結合形成膠原和層粘連蛋白受體,參與細胞間粘附、炎癥和纖維化過程。研究顯示,ITGA1基因突變與多種疾病相關,如癌癥和纖維化,其失調可能通過調節細胞增殖、遷移和組織發育來影響疾病進程。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL,適用于體外檢測生物樣本中ITGA1的蛋白表達量,可支持腫瘤生物學、炎癥機制或纖維化疾病等領域的科學研究,為探討ITGA1在細胞行為調控及疾病進展中的作用提供可靠工具本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CD 49a ELISA Kit; CD49 antigen-like family member A ELISA Kit; CD49a ELISA Kit; CD49a antigen ELISA Kit; Integrin alpha-1 ELISA Kit; ITA1_HUMAN ELISA Kit; Itga 1 ELISA Kit; ITGA1 ELISA Kit; Laminin and collagen receptor ELISA Kit; Very late activation protein 1 ELISA Kit; VLA 1 ELISA Kit; VLA-1 ELISA Kit; VLA1 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.312 ng/mL-20 ng/mL
  • 靈敏度:
    0.078 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human ITGA1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)
    1:1 Average % 100
    Range % 100-105
    1:2 Average % 94
    Range % 89-98
    1:4 Average % 92
    Range % 87-95
    1:8 Average % 102
    Range % 94-107
  • 回收率:
    The recovery of human ITGA1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 97 90-101
    EDTA plasma (n=4) 101 95-107
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 1.958 1.912 1.935 1.801
    10 1.442 1.467 1.455 1.321
    5 0.988 0.945 0.967 0.833
    2.5 0.562 0.551 0.557 0.423
    1.25 0.416 0.423 0.420 0.286
    0.625 0.303 0.309 0.306 0.172
    0.312 0.236 0.231 0.234 0.100
    0 0.133 0.135 0.134  
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
  • 基因功能參考文獻:
    1. It was found that the levels of integrin alpha1 and VE-cadherin mRNA increased during co-culturing of activated endothelium cells with mesenchymal stromal cells. PMID: 29504106
    2. Results suggest that genetic variants in ITGA1 may be involved in the etiology of attention-deficit/hyperactivity disorder and the single-nucleotide polymorphisms -set based analysis is a promising strategy for the detection of underlying genetic risk factors. PMID: 28809852
    3. favors adhesive over migratory fibroblast phenotype PMID: 27294728
    4. Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a/CD18) activation and binding with soluble/immobilized ICAM1 (intercellular cell adhesion molecule 1). PMID: 29079572
    5. Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi. PMID: 28318877
    6. ANGPTL1 inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 signaling pathway. PMID: 28904065
    7. A range of affinities from almost no interaction to the relatively high avidity that characterizes alphaIIbbeta3 is seen between various alpha subunits and beta1 transmembrane and cytosolic domains. PMID: 27929375
    8. Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10, Wnt5a, alpha1 integrin, and matrix metalloproteinase-3 in GS/BMP-4-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage. PMID: 27639333
    9. a comparative study between the wild type integrin alpha1 I and a gain-of-function E317A mutant. NMR HDX results suggest a relationship between regions exhibiting a reduced local stability in the unbound I domain and those that undergo significant conformational changes upon binding. PMID: 27342747
    10. MYC is a key regulating factor for the control of ITGA1 expression in colorectal cancer. PMID: 26096932
    11. Data indicate that CD49a(+) NK cells retain their phenotype after expansion in long-term in vitro cultures. PMID: 25672754
    12. Integrin alpha1 and beta4 are downregulated, following Dendrofalconerol A treatment, in H460 cells. PMID: 25550552
    13. miR-101:DNMT-3B interaction modulates integrin alpha-1 epigenetically. PMID: 24018042
    14. 17-beta-estradiol modulates connexins and integrins as well as ER-beta expression induced by high frequency electromagnetic fields. PMID: 23819010
    15. CD49a promoted Con A-induced hepatitis through enhancing inflammatory cytokine production (IFN-gamma and IL-17A) by CD4(+) T and invariant natural killer T cells. PMID: 24164540
    16. ITGA1 gene SNPs rs1862610, rs24321 43, and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer. PMID: 24124332
    17. small angle x-ray scattering data suggest that at low collagen peptide concentrations the complex exists in equilibrium between a 1:1 and 2:1 alpha1I-peptide complex. PMID: 24187131
    18. CagL is a versatile surface protein equipped with at least two motifs to promote binding to integrins, thereby causing aberrant signaling within host cells and facilitating translocation of CagA into host cells. PMID: 22919661
    19. Pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha strongly promotes pericyte proliferation and migration, and concomitantly induces a switch in pericyte integrins, from alpha1 to alpha2 integrin. PMID: 23448258
    20. Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PMID: 23284937
    21. Collagen receptors alpha(1)beta(1) and alpha(2)beta(1) integrins are involved in transmigration of peripheral blood eosinophils, but not mononuclear cells through human microvascular endothelial cells monolayer PMID: 23070086
    22. Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain. PMID: 22847004
    23. study characterized the collagen binding properties of an activated variant of the alpha1I domain, harboring a gain-of-function mutation E317A; the activated alpha(1)I domain represents a novel conformation of the alphaI domain, mimicking the structural state where the Arg(287)-Glu(317) ion pair has just broken during the integrin activation PMID: 22030389
    24. we have identified a new locus candidate, ITGA1, influencing both fasting glucose and BMD, that may begin to explain the genetic contribution to the epidemiological observations linking type 2 diabetes and osteoporosis PMID: 22698912
    25. study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells PMID: 22298882
    26. There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples. PMID: 22002573
    27. the C-linker has a role as a spring-like element that allows relaxation of the alphaI domain in the resting state and controlled tension of the alphaI domain during activation, exerted by the beta chain PMID: 21965670
    28. alpha(1)beta(1) integrin is of importance not only for the differentiation of mesenchymal cells into myofibroblasts but also for the neovascularization and connective tissue organization PMID: 19397781
    29. Integrin alpha2beta1 might play a more crucial role in maintaining the mechanical creep properties of the collagen matrix than does integrin alpha1beta1. PMID: 21647271
    30. Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing PMID: 21521694
    31. Prostate tissue-derived CD133+ cells exhibited a moderate level of expression of alpha1 integrin PMID: 20531279
    32. Androgens increased INT alpha1 and alpha2 subunits in tubuloepithelial cells and in healthy labial salivary glands. PMID: 20436081
    33. Results show that plumieribetin, a fish lectin from the scorpionfish (Scorpaena plumieri), inhibits alpha1beta1 integrin binding to basement membrane collagen IV. PMID: 19850917
    34. results suggest that the inadequate trophoblastic invasion, induced by antiphospholipid antibodies, can be the result of decreased alpha1 integrin and VE-cadherin and increased alpha5 integrin and E-cadherin expression in the trophoblast PMID: 11937138
    35. role of VLA1 in migration of multiple sclerosis derived antigen-reactive T-cell migration PMID: 12078857
    36. determination of crystal structure in complex with an antibody Fab fragment PMID: 12662928
    37. endometrial integrin alpha1 and alpha4 expression is more consistently present in the early luteal phase in stimulated cycles than in natural cycles PMID: 12694973
    38. VEGF-A induced alpha1 & alpha2 integrins, promoting lymphatic endothelial tube formation & haptotactic migration. Lineage-specific integrin receptor expression contribute to the distinct dynamics of wound-associated angiogenesis & lymphangiogenesis. PMID: 15132990
    39. alpha(1)beta(1) and Col-IV contribute to beta-cell functions known to be important for islet morphogenesis and glucose homeostasis PMID: 15485856
    40. Enhanced expression of Integrin alpha1 is associated with liver metastases from gastrointestinal tumours PMID: 15679046
    41. analysis of binding between collagen type III and integrins alpha1beta1 and alpha2beta1 PMID: 16043429
    42. No statistical difference was observed on the expression of alpha1 integrin subunit expression in endometrium in tubal phimosis or hydrosalpinx PMID: 16412752
    43. identified integrin alpha1 as a protein tyrosine phosphatase type IVA-interacting protein for the first time, and verified this physical association with pull-down and co-immunoprecipitation assays PMID: 16472776
    44. alpha1beta1 integrin is a type IV collagen receptor in pancreatic cancer cells PMID: 17312461
    45. results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment PMID: 17603494
    46. thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. PMID: 17669516
    47. A significant subset of VLA-1-positive effector T cells from rheumatoid arthritis patients persists in vivo and in vitro during monoclonal antibody therapy and contributes to residual and recurring inflammation. PMID: 17891451
    48. are suggestive of the association of ITGA1 with osteoporosis and related risk in postmenopausal women PMID: 17931993
    49. Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. PMID: 17982677
    50. Group B streptococci ACP binds alpha(1)beta(1)-integrin via the D1 domain that promotes GBS internalization within epithelial cells. PMID: 18048918

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin alpha chain family
  • 數據庫鏈接:

    HGNC: 6134

    OMIM: 192968

    KEGG: hsa:3672

    STRING: 9606.ENSP00000282588

    UniGene: Hs.644352



主站蜘蛛池模板: 亚洲国产高清av网站| 亚洲色婷婷六月亚洲婷婷6月| 亚洲高清国产拍精品闺蜜合租| 国产日产欧产精品精品ai| 夜爽8888视频在线观看| 天天狠天天透天干天天怕∴| 人妻.中文字幕无码| 国产成人免费97在线观看| 伦伦影院午夜理论片| 午夜亚洲精品久久一区二区| 国内精品乱码卡一卡2卡麻豆| 日本少妇高潮喷水视频| 亚洲精品久久久久久久久久久| 国产亚洲精品在av| 亚洲亚洲人成综合丝袜图片| 大香伊蕉在人线国产网站首页| 久久成人影院精品777| 日韩高清国产一区在线| 亚洲不卡1卡2卡三卡入口| 在线播放人成视频观看| 国内揄拍国产精品人妻门事件| 国产精品无码翘臀在线观看 | 国产精品无码mv在线观看| 性色av无码一区二区三区人妻 | 国产乱人伦偷精品视频免观看| 亚洲精品成人无码中文毛片不卡| 无码国产成人午夜电影在线观看 | 偷柏自拍亚洲综合在线| 亚洲性色av性色在线观看| 无码h肉在线观看免费一区| 8天堂资源在线| 天堂在线最新版资源www中文| 日产精品久久久久久久蜜臀| 日日摸日日碰夜夜爽无| 99国产欧美另类久久久精品| 日韩久久无码免费毛片软件| 久久99精品久久久久久| 久久精品国产成人av| 日本免费高清一本视频| 国产午夜免费高清久久影院| 换脸国产av一区二区三区|