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  4. Human Gamma-glutamyl hydrolase(GGH) ELISA kit

Human Gamma-glutamyl hydrolase(GGH) ELISA kit

  • 中文名稱：
    人γ谷氨酰水解酶(GGH)酶聯免疫試劑盒
  • 貨號：
    CSB-EL009389HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人γ谷氨酰水解酶(GGH)酶聯免疫試劑盒（CSB-EL009389HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的GGH含量。試劑盒檢測范圍為0.45 ng/mL-30 ng/mL，本試劑盒適用于基礎科研領域，可支持癌癥機制研究、藥物代謝動力學分析、神經退行性疾病模型構建等實驗，尤其適用于對比不同組織或細胞模型中 GGH 表達水平的變化，為探索其在細胞周期調控和氧化應激反應中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Conjugase ELISA Kit; folylpolygammaglutamyl hydrolase ELISA Kit; gamma glutamyl hydrolase ELISA Kit; Gamma-Glu-X carboxypeptidase ELISA Kit; Gamma-glutamyl hydrolase (conjugase; folylpolygammaglutamyl hydrolase) ELISA Kit; Gamma-glutamyl hydrolase ELISA Kit; GGH ELISA Kit; GGH_HUMAN ELISA Kit; gH ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.45 ng/mL-30 ng/mL
  • 靈敏度：
    0.11 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human GGH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %90
    Range %84-94
    1:2Average %96
    Range %91-100
    1:4Average %92
    Range %86-95
    1:8Average %97
    Range %89-100
  • 回收率：
    The recovery of human GGH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9488-97
    EDTA plasma (n=4)10396-106
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    302.728 2.667 2.698 2.582
    151.552 1.478 1.515 1.399
    7.50.761 0.754 0.758 0.642
    3.750.505 0.499 0.502 0.386
    1.80.315 0.323 0.319 0.203
    0.90.238 0.242 0.240 0.124
    0.450.197 0.192 0.195 0.079
    00.118 0.114 0.116
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
  • 基因功能參考文獻：
    1. Either methylation of CpG1 or hypermethylation of CpG2 in GGH promoter region can significantly reduce GGH mRNA expression in pediatric patients with acute leukemia. PMID: 28278270
    2. the results of our study identify GGH as an ERG subtype specific molecular marker with modest prognostic relevance, which may have clinical relevance if analyzed in combination with other molecular markers. PMID: 28146062
    3. the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum PMID: 26676887
    4. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    5. Polymorphism of GGH rs3758149 C>T is associated with response to therapy in acute lymphoblastic leukemia. PMID: 24908438
    6. An interaction term, between FPGS rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to metotrexate toxicity in rheumatoid arthritis. PMID: 24447348
    7. GG genotype of GGH -354 T > G polymorphism may have high predictive value for myelosuppression in methotrexate treated rheumatoid arthritis patients. PMID: 22763757
    8. Suggest that GGH may serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer. PMID: 23374458
    9. Genotyping of DHFR 829C>T and GGH -401C>T was performed using a polymerase chain reaction. PMID: 22994778
    10. The results of our study suggested the potential interest of GGH -401C>T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy. PMID: 23107767
    11. There was no significant difference in gamma-glutamyl hydrolase genotype or T allele frequency between the two groups (P> 0.05). PMID: 22678806
    12. Genetic polymorphism of gamma-glutamyl hydrolase in Chinese acute leukemia children and identification of a novel double nonsynonymous mutation. PMID: 22568793
    13. a SNP in the GGH gene remained associated with reduced CVD risk, with a stronger association in early onset CVD cases. PMID: 22649255
    14. This is one of the first studies to assess FPGS and GGH genetic variants in relation to plasma homocysteine. PMID: 22018726
    15. Genotypes in GGH gene of acute lymphoblastic leukemia patients were evaluated PMID: 21538980
    16. The -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with acute lymphoblastic leukemia. PMID: 20197200
    17. Data revealed that high FPGS gene expression, low GGH gene expression and low ABCC1 gene expression in CRC tissues were predictive factors for a high reduced folate level after LV administration. PMID: 19636555
    18. data implicate GGH as a novel biomarker for bladder cancer; suggest presence of GGH & diazepam-binding inhibitor in urine serves as a rationale for developing them as urinary markers of clinical outcomes for patients treated with neoadjuvant chemotherapy PMID: 19815704
    19. Three-dimensional structure PMID: 11953431
    20. cDNA microarray analysis led to the identification of 2 novel biomarkers that should facilitate molecular diagnosis and further study of pulmonary neuroendocrine tumors. PMID: 15492986
    21. lack of dissociation of the dimer, large monomer-monomer interface, & presence of catalytically essential Tyr-36 in the homodimer interface sequences suggest that homodimer formation is required for hGH monomer to fold into an active conformation. PMID: 16945597
    22. The genotype distribution and gene frequency of the GGH gene polymorphism was studied in a Japanese population. PMID: 17409534
    23. CpG island methylator phenotype (CIMP+) in ColoRectal Cancer (CRC) is associated with low expression of GGH, suggesting involvement of the folate pathway in the development of this phenotype. PMID: 18414409

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  • 亞細胞定位：
    Secreted, extracellular space. Lysosome. Melanosome.
  • 蛋白家族：
    Peptidase C26 family
  • 數據庫鏈接：

    HGNC: 4248

    OMIM: 601509

    KEGG: hsa:8836

    STRING: 9606.ENSP00000260118

    UniGene: Hs.78619



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