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Human Follistatin-related protein 3(FSTL3) ELISA kit

  • 中文名稱:
    人卵泡抑素相關蛋白3(FSTL3)酶聯免疫試劑盒
  • 貨號:
    CSB-EL009026HU
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人卵泡抑素相關蛋白3(FSTL3)酶聯免疫試劑盒(CSB-EL009026HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的FSTL3含量。FSTL3是一種由脂肪組織、生殖系統等釋放的分泌性糖蛋白,參與調節葡萄糖和脂質代謝。研究發現,FSTL3在結直腸癌等癌癥中高表達,與免疫逃逸和抗PD1治療耐藥相關。其研究機制涉及FSTL3與c-Myc的相互作用,抑制CD8 T細胞抗腫瘤效應,增強Tregs浸潤。試劑盒檢測范圍為39 pg/mL-2500 pg/mL,靈敏度為9.7 pg/mL。適用于生命科學領域的基礎研究,如探究FSTL3在代謝調控、生殖生理中的分子機制,或作為疾病模型中的潛在生物標志物研究,其多樣本兼容性可支持體外實驗與動物實驗的配套分析。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    FLRG ELISA Kit; follistatin-like 3 ELISA Kit; follistatin-like 3 glycoprotein ELISA Kit; Follistatin-like protein 3 ELISA Kit; Follistatin-related gene protein ELISA Kit; Follistatin-related protein 3 ELISA Kit; FSRP ELISA Kit; Fstl3 ELISA Kit; FSTL3_HUMAN ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    39 pg/mL-2500 pg/mL
  • 靈敏度:
    9.7 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • 基因功能參考文獻:
    1. FSTL3 expression in invasive breast cancer is inversely associated with tumor size and nuclear grade but it does not predict disease relapse in the short term. PMID: 28178680
    2. first trimester maternal serum levels not altered in women who develop gestational diabetes mellitus PMID: 27623975
    3. Human renal dysfunction is the strongest independent predictor of FSTL3 serum concentrations in multivariate analyses. PMID: 28339962
    4. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
    5. FSTL3 is a critical mediator of exercise-dependent bone formation PMID: 25937185
    6. Elevated FSTL-3 concentrations were attributable to preeclampsia and were associated with increased likelihood of later developing preeclampsia, suggesting further study as a biomarker prior to clinically evident disease. PMID: 24700053
    7. The elevation of Follistatin-like-3 was demonstrated in late second trimester of pregnancy destined to developing preeclampsia, suggesting its causal role in the pathogenesis and prediction of preeclampsia. PMID: 24475769
    8. Resistance exercise resulted in a significant downregulation of MSTN and FBXO32 mRNA expression and a significant upregulation in FSTL3 and SMURF1 mRNA expression, and carbohydrate and protein feeding have little influence on the these markers expression. PMID: 22476926
    9. Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts. PMID: 22915069
    10. Data suggest that serum levels of FSTL3 are higher in pre-eclampsia than in controls; placental expression of FSTL3 is also increased in pre-eclampsia compared with controls; no differences were observed between mild and severe pre-eclampsia. PMID: 22568578
    11. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of follistatin-like protein 3 while postmenopausal women using HT showed a significant increased expression over controls. PMID: 22395277
    12. Maternal and placental FSTL3 concentrations were reduced in GDM women compared with normally pregnant women, suggesting FSTL3 may play an important role in the pathogenesis of gestational diabetes PMID: 22122995
    13. Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. PMID: 22052913
    14. GDF9 decreases basal and activin A-induced FST and FSTL3 expression, and this explains, in part, its enhancing effects on activin A-induced inhibin beta(B)-subunit mRNA expression and inhibin B production in hGL cells PMID: 21829661
    15. FLRG can be successfully detected in maternal plasma in the first trimester of pregnancy but its levels are not significantly altered in the presence of Down syndrome fetuses. PMID: 20063262
    16. First-trimester FSTL3 levels are associated with glucose intolerance and gestational diabetes later in pregnancy. PMID: 20007937
    17. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function PMID: 11948405
    18. our present data suggest that protein kinase C and A signal transduction pathways differently regulate the expression of FLRG in human ovarian granulosa-luteal cells PMID: 12397211
    19. Follistatin and FLRG proteins downmodulate the effects of activin A and BMP2 on erythroid maturation. PMID: 12531697
    20. likely to be a local regulator of activin action in gonadal development and gametogenesis PMID: 14739256
    21. Data report the endometrial mRNA and peptide expression of follistatin-related gene (FLRG), a protein that binds activin-A, preventing its interaction. PMID: 15130517
    22. review discusses differences between signal targets of follistatin and FLRG and distinct functions and mechanisms for these two proteins in the human hematopoietic system PMID: 15451575
    23. comparison of the kinetics of FST isoform and FSTL3 biosynthesis, trafficking, and secretion PMID: 16150905
    24. IGFBP1 and Follistatin-like 3 are highly up-regulated in intrauterine growth restriction in the placenta. PMID: 16338475
    25. the differential biological actions among the FST isoforms and FSTL3 are primarily dependent on their relative cell-surface binding ability and ligand specificity PMID: 16627583
    26. Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver. in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer PMID: 16935389
    27. Ovarian endometriotic lesions show a deranged expression of activin A-binding proteins FLRG and follistatin, which may result in an altered effect of activin A on angiogenesis and/or endometrial differentiation. PMID: 17296189
    28. TNFalpha activates FLRG expression at the transcriptional level. PMID: 17395406
    29. Overexpression of FLRG, an antagonist of activin is associated with increased breast tumor cell growth PMID: 17671190
    30. Data show that the nuclear isoform of FLRG lacks an intrinsic transactivation domain, but enhances AF10-mediated transcription, probably through promoting the homo-oligomerization of AF10, thus facilitating the recruitment of co-activators. PMID: 17868029
    31. Hypoxia enhances the expression of FSTL3 and its release from PHT cells. PMID: 17959243
    32. Elevated myocardial expression of FST-like genes is a feature of heart failure, and may be linked to both disease severity and mechanisms underlying recovery. PMID: 18617621
    33. analysis of the structure of the FSTL3.activin A complex PMID: 18768470
    34. FLRG expression was regulated in the epithelial cytoplasm and nucleus of the malignant breast tissue. PMID: 19740438

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  • 相關疾?。?/div>
    A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
  • 亞細胞定位:
    [Isoform 1]: Secreted.; [Isoform 2]: Nucleus.
  • 組織特異性:
    Expressed in a wide range of tissues.
  • 數據庫鏈接:

    HGNC: 3973

    OMIM: 605343

    KEGG: hsa:10272

    STRING: 9606.ENSP00000166139

    UniGene: Hs.529038



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