在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Fibroblast Growth Factor 8(FGF8) ELISA Kit

  • 中文名稱:
    人成纖維細胞生長因子8(FGF8)酶聯免疫試劑盒
  • 貨號:
    CSB-E15861h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人成纖維細胞生長因子8(FGF8)酶聯免疫試劑盒(CSB-E15861h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的FGF8含量。FGF8是成纖維細胞生長因子家族成員,在胚胎發育中起關鍵作用,調控骨骼、神經和生殖系統等發育。其表達異常可能導致骨骼穩態紊亂和發育畸形。研究機制主要涉及FGF8與FGFR結合調控細胞活動,以及其在特定組織中的表達和功能。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,本試劑盒廣泛應用于基礎研究領域,包括發育生物學中胚胎形態發生機制探索、腫瘤微環境中生長因子信號通路研究,以及神經退行性疾病相關分子調控網絡分析等方向,為體外實驗提供高效的FGF8蛋白定量解決方案。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    AIGF ELISA Kit; Androgen induced growth factor ELISA Kit; Androgen-induced growth factor ELISA Kit; FGF 8 ELISA Kit; FGF-8 ELISA Kit; FGF-8b ELISA Kit; FGF8 ELISA Kit; FGF8_HUMAN ELISA Kit; Fibroblast growth factor 8 (androgen induced) ELISA Kit; Fibroblast growth factor 8 ELISA Kit; Fibroblast growth factor 8 precursor ELISA Kit; HBGF 8 ELISA Kit; HBGF-8 ELISA Kit; HBGF8 ELISA Kit; Heparin-binding growth factor 8 ELISA Kit; HH6 ELISA Kit; KAL6 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human FGF8 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %86-95
    1:2Average %102
    Range %97-107
    1:4Average %91
    Range %85-97
    1:8Average %97
    Range %91-103
  • 回收率:
    The recovery of human FGF8 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9790-100
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.455 2.498 2.477 2.290
    5001.872 1.932 1.902 1.715
    2501.213 1.236 1.225 1.038
    1250.687 0.699 0.693 0.506
    62.50.499 0.484 0.492 0.305
    31.20.379 0.398 0.389 0.202
    15.60.277 0.287 0.282 0.095
    00.188 0.186 0.187
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.
  • 基因功能參考文獻:
    1. The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression of Odontogenic Cyst and Tumors. PMID: 30079292
    2. Study demonstrated that FGF8 can regulate germ cell fate by modulating the dynamic equilibrium between differentiation and self-renewal. PMID: 28898437
    3. FGF8 and FGFR3 may therefore play an important role in the onset of deep zone necrosis and pathogenesis in Kashin-Beck disease in adolescent children. PMID: 29626475
    4. we also found that FGF8 increased the expression of YAP1 and knockdown of YAP1 eliminated the upregulation of EGFR and the resistance to EGFR inhibition induced by FGF8. Our study provides evidence that FGF8 plays an important role in the resistance to EGFR inhibition of human hepatocellular carcinoma cells PMID: 28791365
    5. Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 p.L630P). L630 resides on the ATP binding cleft of the FGFR1 tyrosine kinase domain, and L630P is predicted to cause a complete loss of receptor function. Cell-based assays confirmed that L630P abolishes FGF8 signaling activity PMID: 28195315
    6. Bonferroni adjusted p-value: 0.04). No statistically significant associations were identified in the other ethnic groups. In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA. PMID: 27237708
    7. in one holoprosencephaly (HPE) family, a deleterious FGFR1 allele was transmitted from one parent and a loss-of-function allele in FGF8 from the other parent to both affected daughters. This family is one of the clearest examples to date of gene:gene synergistic interactions causing HPE in humans. PMID: 26931467
    8. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed. PMID: 27273073
    9. Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein PMID: 23994638
    10. Our results link FGF8, c-Abl and p300 in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity. PMID: 25911675
    11. Data indicate that overexpression of fibroblast growth factor 8 (FGF8) correlates with lymph node metastasis and poor prognosis in colorectal cancer (CRC). PMID: 25473897
    12. FGF8 mutations (p.Gly29_Arg34dup and p.Pro26Leu) contribute to the formation of the VATER/VACTERL association. PMID: 25131394
    13. Scube3 may be a critical upstream regulator of fast fiber myogenesis by modulating fgf8 signaling during zebrafish embryogenesis PMID: 24849601
    14. Together, these data demonstrate that FGF (FGFR-2 and Fgf8)signaling regulates cell proliferation and cell polarity and that these cell processes contribute to facial morphogenesis. PMID: 23906837
    15. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. PMID: 24464787
    16. genetic association study in population in Massachusetts: Data suggest that clinical features in Kallmann syndrome (KS) are associated with genetic causes: dental agenesis/digital bony abnormalities are associated with variations/mutations in FGF8. PMID: 23533228
    17. A novel FGF8b-binding peptide with anti-tumor effect on prostate cancer. PMID: 23466786
    18. The results suggest that prolonged and enhanced human fibroblast growth factor 8b signaling induces dramatic changes in the epididymis and testis that lead to infertility in a portion of the human fibroblast growth factor 8b transgenic male mice. PMID: 22423049
    19. genetic association studies in 103 patients from US and UK: Mutations in FGF8, FGFR1, or PROKR2 contributed to 7.8% of patients with combined pituitary hormone deficiency or septo-optic dysplasia. Data suggest genetic overlap with Kallmann syndrome. PMID: 22319038
    20. In vivo stimulation of BT-474 cell growth by progesterone is associated with down-regulation of FGF-8. PMID: 22237711
    21. We implicate FGF8 in the etiology of recessive holoprosencephaly and potentially septo-optic dysplasia/Moebius syndrome PMID: 21832120
    22. This novel mechanism of viral-mediated FGF8 upregulation may implicate a new role of oncoviruses in human carcinogenesis. PMID: 21119603
    23. FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. PMID: 21319186
    24. FGF8b is able to induce fast growth in strongly hypoxic tumour microenvironment whereas VEGF-stimulated growth advantage is associated with improved perfusion and oxygenation of prostate tumour xenografts PMID: 21034500
    25. Results suggest that increased FGF-8 in human prostate may also contribute to prostate tumorigenesis by stromal activation. PMID: 21076617
    26. We identified the first nonsense mutations in the FGF8 gene in familial isolated hypogonadotropic hypogonadism with variable degrees of GnRH deficiency and olfactory phenotypes, confirming that loss-of-function mutations in FGF8 cause GnRH deficiency. PMID: 20463092
    27. widespread expression pattern suggests FGF8 has physiological roles in adult tissue as well as in development PMID: 11953856
    28. Promoter of FGF8 reveals a unique regulation by unliganded RARalpha. PMID: 12054865
    29. Regulation of FGF8 expression by the androgen receptor in human prostate cancer. PMID: 12140757
    30. isoform b isoform expressed in prostate cancer, and is of prognostic value PMID: 12778074
    31. Repression of fgf8 might be directly or indirectly involved in this transcriptional control by TGF-beta. PMID: 15935652
    32. We also show that the mode of FGF8 receptor-binding specificity is distinct from that of other FGFs and provide the first biochemical evidence for a physiological FGF8b-FGFR1c interaction during mid-hindbrain development. PMID: 16384934
    33. novel role for nuclear factor-kappaB in the regulation of fibroblast growth factor 8(FGF8) expression in prostate cancer cells is uncovered PMID: 16683270
    34. These results indicate that mutations are rare in FGF8 and FGFR2 in hypospadias, but gene variants may influence the risk. PMID: 17264867
    35. FGF8 has a role in regulation of autocrine and paracrine loops in the growth regulation of breast, prostate and ovarian cancer [review] PMID: 17512240
    36. Fgf8 is required for the node to impart left-right asymmetry on specific tissues Excess Fgf8 signaling following a loss of RA may stimulate the node to generate asymmetry in presomitic mesoderm, leading to left-right asymmetry in somitogenesis clock PMID: 17600781
    37. FGF-8 is expressed at a high frequency in bone metastases of human prostate cancer and expression of FGF-8 in PC-3 prostate cancer cells increases their growth as intratibial tumors. PMID: 18386787
    38. Decreased FGF8 signaling causes deficiency of GnRH in humans. PMID: 18596921
    39. associated gene expression signature suggests potential mediators for FGF-8b actions on prostate cancer progression and metastasis PMID: 19415685

    顯示更多

    收起更多

  • 相關疾病:
    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 數據庫鏈接:

    HGNC: 3686

    OMIM: 600483

    KEGG: hsa:2253

    STRING: 9606.ENSP00000321797

    UniGene: Hs.57710



主站蜘蛛池模板: 无码av一区二区大桥久未| 久久久久久亚洲精品中文字幕| 亚洲国产日韩精品一区二区三区| 中国精品偷拍区偷拍无码| 在线人视频观看免费| av无码天一区二区一三区| 亚洲熟女乱综合一区二区| 亚洲人成网站观看在线播放| 中国内射xxxx6981少妇| 欧美成人精品一区二区三区色欲| 国模小黎自慰gogo人体| 日韩中文字幕区一区有砖一区| yyyy11111少妇影院| 国产 | 欧洲野花视频天堂视频p| 欧美一区二区三区成人片在线| 久久久久有精品国产麻豆| 日本一道一区二区视频| 国产精品久久久久影院色| 国产亚洲精品久久久久久牛牛| 免费国产a国产片高清网站| 亚洲一线产区二线产区分布| 久久无码人妻一区二区三区午夜| 国产精品久久国产精品99 gif | 免费播放婬乱男女婬视频国产 | 欧美成人精品三级网站视频| 亚洲精品黑牛一区二区三区| 亚洲综合无码精品一区二区三区| 四虎成人永久在线精品免费| 亚洲欧美中文日韩v在线97| 秋霞特色aa大片| 色一情一乱一伦一区二区三区| 开心色婷婷色五月激情| 欧美熟妇色ⅹxxx欧美妇| 久久国产36精品色熟妇| 国产毛片毛多水多的特级毛片| 熟女人妻av完整一区二区三区| 亚洲 欧美 国产 日韩 中文字幕| 香港日本三级亚洲三级| 久久成人网站亚洲综合| 国产亚州精品女人久久久久久| 宅男666在线永久免费观看|