在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Fetuin A ELISA Kit

  • 中文名稱:
    人胎球蛋白A酶聯免疫試劑盒
  • 貨號:
    CSB-E12882h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人胎球蛋白A酶聯免疫試劑盒(CSB-E12882h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養上清液、組織勻漿、尿液樣本中的AHSG含量。AHSG即α2-HS糖蛋白,是肝臟合成的血漿糖蛋白。在生理中它參與鈣穩態等過程。研究機制方面,其在代謝、免疫等領域受關注,如可能影響胰島素敏感性、參與炎癥調節,在糖尿病、心血管疾病等病理進程中作用受科研人員持續探究。試劑盒檢測范圍為15.6 ng/mL-1000 ng/mL,靈敏度為3.9 ng/mL。科研人員可借助在基礎醫學研究中探索胎球蛋白A在代謝性疾病模型中的作用機制,或在心血管疾病動物實驗中分析其表達動態,同時支持臨床前藥物研發階段對生物標志物的定量評估。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    59 kDa bone sialic acid-containing protein ELISA Kit; A2HS ELISA Kit; Aa2-066 ELISA Kit; AHS ELISA Kit; Ahsg alpha-2-HS-glycoprotein ELISA Kit; Ahsg ELISA Kit; Alpha 2 HS Glycoprotein ELISA Kit; Alpha 2 Z globulin ELISA Kit; Alpha-2-HS-glycoprotein ELISA Kit; Alpha-2-HS-glycoprotein chain B ELISA Kit; Alpha-2-Z-globulin ELISA Kit; Asialofetuin ELISA Kit; Ba alpha 2 glycoprotein ELISA Kit; Ba-alpha-2-glycoprotein ELISA Kit; BSP ELISA Kit; Countertrypin ELISA Kit; Fetua ELISA Kit; FETUA_HUMAN ELISA Kit; Fetuin ; mouse; homolog of ELISA Kit; Fetuin A ELISA Kit; Fetuin-A ELISA Kit; Glycoprotein PP63 ELISA Kit; HSGA ELISA Kit; pp63 ELISA Kit
  • 縮寫:
    AHSG
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates, urine
  • 檢測范圍:
    15.6 ng/mL-1000 ng/mL
  • 靈敏度:
    3.9 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Metabolism
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human fetuin A in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1000 Average % 95  
    Range % 90-100  
    1:2000 Average % 94  
    Range % 91-99  
    1:4000 Average % 92  
    Range % 88-98  
    1:8000 Average % 93  
    Range % 84-102  
  • 回收率:
    The recovery of human fetuin A spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 97 92-106  
    EDTA plasma (n=4) 98 91-105  
                 
                 
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    1000 2.754 2.797 2.776 2.564  
    500 2.312 2.354 2.333 2.121  
    250 1.563 1.554 1.559 1.347  
    125 0.735 0.753 0.744 0.532  
    62.5 0.538 0.526 0.532 0.320  
    31.2 0.322 0.335 0.329 0.117  
    15.6 0.268 0.284 0.276 0.064  
    0 0.211 0.213 0.212    
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展:
        胎球蛋白 A (alpha-fetoprotein, AFP) 是一種在人類胚胎和胎兒發育期間表達的蛋白質,在成年人中只有極低水平的表達。AFP是一種肝細胞癌的重要標志物,也被廣泛用于孕期篩查和診斷胎兒畸形的指標。
    以下是最近一些關于AFP的研究進展:
        AFP在肝癌中的作用:AFP被認為是肝癌干細胞的標記物之一,因此在肝癌治療中具有重要作用。最近的研究表明,AFP通過調節Wnt/β-catenin信號通路來促進肝癌細胞的增殖和轉移。
        AFP與自身免疫性疾病的關系:最近的研究表明,AFP可能與自身免疫性疾病的發生有關。研究人員發現,自身免疫性甲狀腺疾病患者血清中的AFP水平較高,這表明AFP可能與自身免疫性疾病的發生有關。
        AFP在胚胎干細胞和肝細胞再生中的作用:最近的研究表明,AFP在胚胎干細胞和肝細胞再生中起著重要作用。研究人員發現,AFP可以促進胚胎干細胞向肝細胞的分化,并且在肝細胞再生過程中也發揮了重要作用。
        AFP在腫瘤免疫治療中的應用:最近的研究表明,AFP可以作為腫瘤免疫治療的靶點之一。研究人員利用AFP的表達水平來選擇肝細胞癌患者進行免疫治療,并且發現這種治療方法在一些患者中取得了良好的效果。
  • 功能:
    Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
  • 基因功能參考文獻:
    1. Serum Fetuin-A levels in septic patients decreased significantly in the first 24 hours, followed by an insignificant increase at 72 hours. PMID: 29968890
    2. Considering the role of fetuin-A in tissue calcification and inflammation, higher serum fetuin-A levels should be measured in patients with basal ganglia calcification PMID: 29288724
    3. This review is focused on work that has been done regarding fetuin-A potential role(s) in tumor progression and sequelae of diabetes. [review] PMID: 30060600
    4. In conclusion, Fetuin A, vitamin D, and intact PTH levels were all associated with sarcopenia in this geriatric population. Among them, intact PTH specifically indicates patients with sarcopenic left ventricular hypertrophy. PMID: 28112206
    5. fetuin a to adiponectin ratio is more strongly associated with metabolic syndrome and its components than fetuin-A or adiponectin alone PMID: 28779425
    6. High levels of fetuin-A and TGFbeta1 reported in patients with axial spondyloarthropathies. PMID: 26799059
    7. fetuin-A can be an alternative marker for insulin resistance and cardiovascular risk in prepubertal children PMID: 28154244
    8. rs4917 T allele carriers had higher triglycerides (TG). This relationship was exaggerated in individuals with overweight and obesity. Dietary intake was significantly associated with TG in only those with heterozygosity at rs4917, suggesting that these individuals may be more susceptible to dietary interventions. PMID: 28858873
    9. Although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, data from this study does not support a strong, relevant relationship between circulating fetuin-A and risk of diabetes type 2 in the general European population studied. PMID: 29523632
    10. In overweight-to-obese older men, exercise/weight loss therapy appears to increase plasma fetuin-A levels, which is related to improvements in aerobic capacity. PMID: 28770230
    11. Higher fetuin-A levels are associated with incident type 2 diabetes in both males and females. PMID: 29439057
    12. Data suggest that plasma fetuin-A levels are down-regulated in type 2 diabetes with peripheral arterial disease, irrespective of traditional cardiovascular risk factors; fetuin-A may be involved in lower extremity arterial calcification in type 2 diabetes. PMID: 27899247
    13. Data suggest that, in children with type I diabetes, serum levels of osteoprotegerin are up-regulated, serum levels of RANKL are unchanged, and serum levels of fetuin-A are down-regulated. (RANKL = receptor activator of nuclear factor kappa B ligand) PMID: 27028343
    14. Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of rheumatoid arthritis. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the rheumatoid arthritis. PMID: 27152709
    15. the studies demonstrate the impact of fetuin-A as significant node of growth, motility, and invasion signaling in glioblastomas that can be targeted for therapy. PMID: 27882696
    16. Lower plasma fetuin-A levels were associated with an increased risk of all-cause and CVD mortality in patients with coronary artery disease independently of traditional CVD risk factors. PMID: 28912366
    17. thus creates an inflammatory environment in the pancreatic islets that can become a possible cause behind pancreatic beta-cell dysfunction in chronic hyperlipidemic condition PMID: 28797566
    18. In kidney disease, low circulating Fet-A concentrations are associated with progressive aortic stiffening and calcification. [review] PMID: 27190332
    19. The over-secretion of alpha-2-Heremans-Schmid glycoprotein by visceral adipose tissue, the increased secretion of the active phosphorylated form by subcutaneous adipose tissuein obese animals, and the adipose-derived alpha-2-Heremans-Schmid glycoprotein capacity to inhibit the insulin pathway suggest the participation of adipose-derived alpha-2-Heremans-Schmid glycoprotein in the deleterious effects of obesity. PMID: 27738888
    20. AHSG can be used to distinguish between inflammatory bowel disease and irritable bowel syndrome patients or healthy controls while at the same time "predicting" complicated disease behavior, need for therapy escalation and surgery. PMID: 28210079
    21. Lower baseline fetuin A levels and the presence of VC were independently linked to higher risk of incident fractures in prevalent dialysis patients PMID: 27398932
    22. present whole-exome sequencing results of a large consanguineous family segregating APMR syndrome with seven affected family members. Our study revealed a novel predicted pathogenic, homozygous missense mutation in the AHSG (OMIM 138680) gene PMID: 28054173
    23. fetuin A positively predicts circulating fetuin B in gestational diabetes mellitus PMID: 28183456
    24. Predictive role of the hepatokine fetuin A as a noninvasive biomarker of hepatic steatosis in preoperative settings. Compared to non-NAFLD subjects fetuin A was increased in NAFLD (p = .009) and in NASH (p = .029). PMID: 26980291
    25. The rs4918 minor variant is associated with lower TNFalpha and adiponectin, higher leptin levels in healthy persons, and more favorable anthropomorphic parameters of obesity. The G allele was more frequent among lean than obese patients (RR=1.067, 95%CI=1.053-2.651, p=0.015). An association between BMI and rs4918 polymorphism was observed among patients without diabetes but not in diabetics. PMID: 27487851
    26. fetuin-A does not have a role in the overall risk of cardiovascular disease PMID: 27038419
    27. Significant disturbance in serum and urinary fetuin-A levels, which was related to renal functions, had occurred during HDMTX and persisted for at least 4 months after the consolidation. Serum and urine fetuin-A could be sensitive markers for subtle renal dysfunction in ALL children. PMID: 26268515
    28. Serum fetuin-A level is not associated with disease progression and death and does not enhance risk prediction in non-dialysis chronic kidney disease stages 3-5. PMID: 27334353
    29. Increased serum visfatin, fetuin-A, and PTX3 levels, and the presence of positive correlation between visfatin, fetuin-A, and Psoriasis area and severity index, probably reflect the inflammatory state and insulin resistance seen in psoriasis. PMID: 25867925
    30. peritoneal dialysis patients with heart failure have significantly lower fetuin-A levels PMID: 24990392
    31. Study showed that serum levels of Fetuin-A are linked to serum calcium homeostasis and AHSG genotype but not with coronary artery calcification severity in subjects without coronary vasculopathy. PMID: 26825086
    32. Serum fetuin-A concentrations are independently correlated with VEGF and CRP concentrations in T2DM patients with DR, but not in NDR subjects PMID: 26851648
    33. From infancy to aging: Biological and behavioral modifiers of Fetuin-A. PMID: 26740309
    34. Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis. PMID: 26828753
    35. Common variants in the AHSG gene are strongly associated with fetuin-A levels, but their concurrent association with CHD risk in current prospective studies is inconsistent PMID: 26343871
    36. results indicated that the cis-regulatory expressional difference of AHSG is expected to occur at the level of transcription or splicing of mRNA PMID: 26549924
    37. Data suggest that serum fetuin-A (FETUA/AHSG) concentrations are signi fi cantly positively associated with serum VEGFA (vascular endothelial growth factor A) levels in patients with newly diagnosed type 2 diabetes. PMID: 26156593
    38. Reanalysis of a total of 47 MDS patients revealed biomarker candidates, with alpha-2-HS-glycoprotein and leucine-rich alpha-2-glycoprotein as the most promising candidates. PMID: 26448929
    39. AHSG is up-regulated in hypopharyngeal squamous cell carcinoma may be employed as a potential biomarker for its early diagnosis PMID: 26464644
    40. The T nucleotide in rs4917 of AHSG is associated with more favorable lipid status among healthy persons (i.e., lower low-density lipoprotein cholesterol) and anthropologic parameters of obesity in cohort 2. PMID: 25695715
    41. In this large sample of community-dwelling older adults, a small positive association between fetuin-A and areal BMD appeared attributable to confounding variables and we found no evidence of an association between fetuin-A and risk of clinical fracture. PMID: 25656814
    42. The study findings showed that plasma sCD40L, fetuin-A, and PAPP-A levels are associated with carotid plaque formation and instability. PMID: 26214492
    43. There are increased carotid intima-media thickness values, decreased fetuin-A levels, but unchanged ABI values in patients with normotensive COPD. PMID: 23799555
    44. Fetuin-A is a novel risk marker for coronary artery disease in asymptomatic young adults. PMID: 25679296
    45. These findings establish urinary Fetuin-A as a sensitive biomarker of the progression of autosomal dominant polycystic kidney disease. PMID: 25888842
    46. Report increased secretion of Fetuin A, LBP and HMGB-1 from subcutaneous adipose tissue in metabolic syndrome. PMID: 25978344
    47. The present study demonstrates that fetuin-A 742 (C/T) and 766 (C/G) genotypes may be risk factors for myocardial infarction in patients older than 40 years of age. PMID: 25815703
    48. serum concentrations significantly associated with elevated fatty liver index, ALT, and AST, the early indicators of nonalcoholic fatty liver disease PMID: 26426614
    49. Circulating fetuin-A could be a useful serum biomarker for predicting liver and vascular fibrosis progression in fatty liver disease patients. PMID: 25627311
    50. Data indicate that the effect of testosterone on fetuin-A (alpha-2-HS-glycoprotein, AHSG) mRNA levels was abrogated by silencing of the androgen receptor in HepG2 cells. PMID: 25011927

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Fetuin family
  • 組織特異性:
    Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
  • 數據庫鏈接:

    HGNC: 349

    OMIM: 138680

    KEGG: hsa:197

    STRING: 9606.ENSP00000393887

    UniGene: Hs.324746



主站蜘蛛池模板: 内射国产内射夫妻免费频道| 在线观看免费视频网站a站| 天堂资源中文| 90后极品粉嫩小泬20p| 色欲aⅴ亚洲情无码av蜜桃| 免费观看国产小粉嫩喷水| 久久青青草免费线频观| 少妇性bbb搡bbb爽爽爽欧美| 青春草在线视频免费观看| 免费国产成人高清在线视频 | 最新亚洲一卡二卡三卡四卡| 国产精品亚洲二区在线观看| 99热这里有精品| 大香线蕉伊人精品超碰| 国产亚洲曝欧美曝妖精品| 妺妺窝人体色www看人体| 加勒比一本heyzo高清视频| 小说区亚洲综合第1页| 日韩理论午夜无码| 2020久久天天躁狠狠躁夜夜| 中文字幕人妻丝袜乱一区三区| 小sao货水好多真紧h视频| 国产日韩欧美亚洲精品中字 | 综合久久国产九一剧情麻豆| 亚洲欧美不卡高清在线观看| 女人高潮抽搐喷液30分钟视频| 国产97色在线 | 国产| 中文字幕丝袜精品久久| 亚洲国产精品无码久久sm| 国产成人精品无码一区二区| 免费国产va在线观看| 人妻出差精油按摩被中出| 国产精品日本一区二区不卡视频| 天天做天天爱夜夜爽| 国产卡二卡三卡四卡免费网址| 国产aⅴ精品一区二区三区| 乱人伦人妻中文字幕无码| 开心五月综合亚洲| 国产成人精品999视频| 大胆欧美熟妇xxbbwwbw高潮了| 99久久国语露脸精品国产|