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  4. Human Eosinophil peroxidase(EPX) ELISA kit

Human Eosinophil peroxidase(EPX) ELISA kit

  • 中文名稱：
    人嗜酸性粒細(xì)胞過氧化酶(EPX)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL007756HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人嗜酸性粒細(xì)胞過氧化酶(EPX)酶聯(lián)免疫試劑盒（CSB-EL007756HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的EPX含量。人嗜酸性粒細(xì)胞過氧化酶（EPX）是一種存在于嗜酸性粒細(xì)胞中的酶，參與炎癥反應(yīng)和細(xì)胞損傷。其功能包括產(chǎn)生氧化應(yīng)激和破壞細(xì)胞外基質(zhì)，在嗜酸性粒細(xì)胞增多相關(guān)疾病（如嗜酸性粒細(xì)胞性食管炎）的發(fā)病機制中起重要作用。試劑盒檢測范圍為3.12 ng/mL-200 ng/mL，適用于體外實驗和基礎(chǔ)研究中EPX表達(dá)水平的動態(tài)監(jiān)測，例如炎癥模型構(gòu)建、藥物作用評估或細(xì)胞因子網(wǎng)絡(luò)調(diào)控分析。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Eosinophil peroxidase [Precursor] ELISA Kit; Eosinophil peroxidase ELISA Kit; Eosinophil peroxidase heavy chain ELISA Kit; EPER ELISA Kit; EPO ELISA Kit; EPP ELISA Kit; EPX ELISA Kit; EPX PEN ELISA Kit; PERE ELISA Kit; PERE_HUMAN ELISA Kit
  • 縮寫：
    EPX
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    3.12 ng/mL-200 ng/mL
  • 靈敏度：
    0.78 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human EPX in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 87  
    Range % 80-95  
    1:2 Average % 95  
    Range % 90-100  
    1:4 Average % 92  
    Range % 87-99  
    1:8 Average % 97  
    Range % 92-102  
  • 回收率：
    The recovery of human EPX spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 90 86-96  
    EDTA plasma (n=4) 95 90-101  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    200 1.952 1.872 1.912 1.818  
    100 1.411 1.385 1.398 1.304  
    50 0.842 0.804 0.823 0.729  
    25 0.444 0.419 0.432 0.338  
    12.5 0.272 0.254 0.263 0.169  
    6.25 0.181 0.169 0.175 0.081  
    3.12 0.131 0.121 0.126 0.032  
    0 0.097 0.091 0.094 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
  • 基因功能參考文獻(xiàn)：
    1. peroxidase enzymes, like MPO and EPO, may play a fundamental role in inhibiting RANKL-induced osteoclast differentiation at inflammatory sites of bone fracture and injury. PMID: 27836774
    2. Both MPO and EPO are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis. PMID: 28260049
    3. The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor PMID: 27519953
    4. EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma. PMID: 27587397
    5. there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum. PMID: 26645423
    6. Myeloperoxidase and eosinophil peroxidase are readily internalized by HUVEC cells where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo. PMID: 26386352
    7. A preferential role of EPO signaling via a specific surface receptor that leads to neural plasticity. PMID: 24937179
    8. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation. PMID: 24814827
    9. Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. PMID: 23931643
    10. report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (EPX/EDN, RNase2) and the association with the cellular contents of EPX/EDN and ECP PMID: 24738159
    11. Polymorphisms of EPX and ECP are associated to inflammatory bowel disease in an age and gender dependent manne. PMID: 23197886
    12. Data indicate that eosinophil peroxidase (EPX)-based ELISA is the only eosinophil-specific assay. PMID: 22750539
    13. A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells. PMID: 22702502
    14. HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation. PMID: 21454806
    15. EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders PMID: 20501663
    16. induces surface alteration, killing, and lysis of Mycobacterium tuberculosis PMID: 12540536
    17. results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis PMID: 14657871
    18. Polymorphisms of the eosinophil peroxidase gene may be associated with Japanese cedar pollinosis. PMID: 15316147
    19. Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO) PMID: 15894800
    20. The mechanisms by which eosinophil peroxidase oxidizes nitrite are reported. PMID: 16336215
    21. post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase PMID: 18694936
    22. No variation in genes eosinophil peroxidase for Atopic dermatitis pathogenesis in this German cohort. PMID: 19014520
    23. Genetic variability in the EPO gene may contribute to the susceptibility to allergic rhinitis (or related phenotypes) in the Czech population. PMID: 19439985

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  • 相關(guān)疾病：
    Eosinophil peroxidase deficiency (EPXD)
  • 亞細(xì)胞定位：
    Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
  • 蛋白家族：
    Peroxidase family, XPO subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3423

    OMIM: 131399

    KEGG: hsa:8288

    STRING: 9606.ENSP00000225371

    UniGene: Hs.279259



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