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  4. Human Complement 1q,C1q ELISA Kit

Human Complement 1q,C1q ELISA Kit

  • 中文名稱：
    人補體1q(C1q)酶聯免疫試劑盒
  • 貨號：
    CSB-E10118h
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人補體1q(C1q)酶聯免疫試劑盒（CSB-E10118h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的C1QB含量。C1QB是補體系統C1復合物的重要組成部分，補體系統在免疫防御等過程中發揮關鍵作用。相關研究主要圍繞其在補體激活機制中的功能展開，探究其與免疫相關疾病的關聯、在信號傳導中的作用等，旨在為疾病治療提供新靶點和思路。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于科研領域中C1q相關的免疫調控機制研究、疾病模型構建或藥物干預效果評估等場景，例如通過檢測實驗動物血清或組織中的C1q濃度，探究其在炎癥性疾病或神經退行性疾病中的分子作用機制，為相關基礎研究提供可靠數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    C1qb ELISA Kit; C1QB_HUMAN ELISA Kit; Complement C1q subcomponent subunit B ELISA Kit; Complement component 1 q subcomponent B chain ELISA Kit; Complement component 1 q subcomponent beta polypeptide ELISA Kit; Complement component C1q B chain ELISA Kit; Complement subcomponent C1q chain B ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human C1q in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 103
    Range % 100-106
    1:2 Average % 99
    Range % 92-106
    1:4 Average % 89
    Range % 85-93
    1:8 Average % 94
    Range % 90-98
  • 回收率：
    The recovery of human C1q spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 105 102-108
    EDTA plasma (n=4) 95 90-99
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.015 1.952 1.984 1.859
    5 1.758 1.878 1.818 1.693
    2.5 1.514 1.569 1.542 1.417
    1.25 0.995 0.968 0.982 0.857
    0.625 0.614 0.632 0.623 0.498
    0.312 0.475 0.457 0.466 0.341
    0.156 0.334 0.355 0.345 0.220
    0 0.123 0.126 0.125 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • 基因功能參考文獻：
    1. C1QB expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. We identified a major linear epitope of C1q that is the target of anti-C1q in systemic lupus erythematosus. PMID: 22740328
    3. The susceptibility for schizophrenia was particularly associated with C1QB rs291982 GG genotype. PMID: 21951915
    4. a 2-gene signature consisting of PLEK2 and C1QB led to the best result that correctly classified 93.3% melanoma patients and 90% healthy controls PMID: 21698244
    5. The C-terminal globular region of the C1Q B chain may have evolved as a functionally specialized domain or module with distinct binding properties which together with the A and C chains confers versatility and flexibility to the whole C1q molecule. PMID: 12847249
    6. Complementary interacting sites on the C1q globular domain have been precisely defined. Characterization of point mutants suggests a central role for Arg114 and a complementary role for Arg129, Arg163, and His117 of C1Q B chain in the C1q-IgG interaction. PMID: 15034050
    7. The first analysis of C1q by mass spectrometry yields evidence that the B chain moiety of the globular head is involved in the interaction with fucoidan and underscores the particular role of arginine-109 in the charge pattern recognition property of C1q. PMID: 15709773
    8. results suggest that charged residues belonging to the apex of the gC1q heterotrimer (with participation of all three chains) as well as the side of the ghB are crucial for C1q binding to ligands, IgG1, C-reactive protein, and pentraxin 3. PMID: 16566583
    9. No C1q or low molecular weight C1q was detected in sera and no anti-C1q autoantibodies were found. Sequencing of the C1q genes revealed a novel missense mutation (Gly-Arg) in codon 217 of the B chain. PMID: 17513176

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  • 相關疾病：
    Complement component C1q deficiency (C1QD)
  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：

    HGNC: 1242

    OMIM: 120570

    KEGG: hsa:713

    STRING: 9606.ENSP00000313967

    UniGene: Hs.8986



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