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Human Brain derived neurotrophic factor,BDNF ELISA Kit

  • 中文名稱:
    人腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-E04501h-IS
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人腦源性神經(jīng)營養(yǎng)因子(BDNF)酶聯(lián)免疫試劑盒(CSB-E04501h-IS)為雙抗夾心法ELISA試劑盒,定量檢測樣本中的BDNF含量。BDNF即腦源性神經(jīng)營養(yǎng)因子,是神經(jīng)系統(tǒng)中重要的神經(jīng)營養(yǎng)因子。它在神經(jīng)發(fā)育、存活、再生和突觸可塑性中起關(guān)鍵作用。其研究機(jī)制聚焦于與受體結(jié)合激活信號通路,調(diào)節(jié)神經(jīng)細(xì)胞功能,對神經(jīng)退行性疾病等治療的潛在價值是研究熱點(diǎn)??蒲蓄I(lǐng)域可用于探索BDNF在神經(jīng)系統(tǒng)發(fā)育、疾病病理機(jī)制中的作用,或用于評估藥物干預(yù)、基因編輯等實驗手段對BDNF表達(dá)的影響,為神經(jīng)科學(xué)基礎(chǔ)研究、藥物篩選模型構(gòu)建提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Abrineurin ELISA Kit; ANON2 ELISA Kit; BDNF ELISA Kit; BDNF_HUMAN ELISA Kit; Brain Derived Neurotrophic Factor ELISA Kit; Brain-derived neurotrophic factor ELISA Kit; BULN2 ELISA Kit; MGC34632 ELISA Kit; Neurotrophin ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates.
  • 檢測范圍:
    62.5 pg/ml-4000 pg/ml
  • 靈敏度:
    15.6 pg/ml
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of human BDNF in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:20

    Average %

    99

    Range %

    92-106

    1:40

    Average %

    103

    Range %

    96-110

    1:80

    Average %

    90

    Range %

    85-95

    1:160

    Average %

    95

    Range %

    88-102

  • 回收率:

    The recovery of human BDNF spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    91

    86-97

    EDTA plasma (n=4)

    97

    91-103

  • 標(biāo)準(zhǔn)曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    4000

    2.999

    2.904

    2.952

    2.773

    2000

    2.241

    2.167

    2.204

    2.026

    1000

    1.338

    1.268

    1.303

    1.125

    500

    0.798

    0.819

    0.808

    0.630

    250

    0.476

    0.461

    0.468

    0.290

    125

    0.300

    0.293

    0.296

    0.118

    62.5

    0.243

    0.234

    0.238

    0.060

    0

    0.174

    0.183

    0.178

     

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
  • 基因功能參考文獻(xiàn):
    1. The sample consisted of 181 suicide cases (47 early suicide cases, 134 late suicide cases) and 162 controls. Patients with the BDNF Met allele had a 1.42-fold increased risk of suicide when compared with the Val allele carrier. When a suicide case is stratified by occurrence time, patients with the Met/Val or Met/Met genotype had a 2.48-fold increased risk of committing suicide early than those with the Val/Val genotype. PMID: 29734216
    2. Low brain derived neurotrophic factor may contribute to the pathogenesis of schizophrenia, but maybe not to its cognitive impairments. PMID: 29482040
    3. In a 12-year longitudinal population-based sample of older adults (n = 2,218), we used growth curve modeling to investigate whether the benefits of physical activity on cognitive preservation differed by BDNF genotype and sex across multiple cognitive domains including processing speed, attention, working memory, and episodic verbal memory. PMID: 29402782
    4. Mn-SOD V allele carries a worse outcome profile after stroke, relating to nitrosative stress, inflammatory, and apoptotic response and associated with a BDNF reduction. PMID: 30150066
    5. while the BDNF Val66Met Megroup displayed significant SICI reduction in the bilateral M1 in response to motor training, short-interval intracortical inhibition (SICI) remained unchanged in the BDNF Val66Met group. PMID: 29856758
    6. Our study provides evidence for the correlation between the BDNF variant rs6265 and emotional symptoms in the early phase after mild traumatic brain injury. PMID: 29357818
    7. These results indicate that genetic variant Met66 decreased the serum BDNF levels in combination with self-reported risk-taking propensity among heroin users. PMID: 30134233
    8. serum BDNF levels and the BDNF Val66Met polymorphism in healthy young adults were associated with the sleep pattern on weekends but not with that on weekdays, suggesting that the systems involved in BDNF control may be linked to endogenous sleep characteristics rather than the socially constrained sleep schedule in healthy young adults. PMID: 29944703
    9. Neurotrophic factors and hippocampal activity in PTSD PMID: 29799860
    10. upregulation of PAI-1 may be a critical mechanism underlying insufficient neurotrophic support and increased neurodegeneration associated with AD. Thus, targeting BDNF maturation through pharmacological inhibition of PAI-1 might become a potential treatment for AD. PMID: 28132883
    11. This study shows the genetic correlates of early trauma in a group of schizophrenia patients (BDNF Met carriers). PMID: 28711474
    12. This study demonstrated significant differences in the blood levels of BDNF between people with epilepsy and healthy subjects. PMID: 30140987
    13. Study shows that brain-derived neurotrophic factor concentrations in serum and peritoneal fluid were significantly higher in women with endometriosis with pain compared to women with endometriosis without pain. PMID: 28954602
    14. Met allele of the Val66Met polymorphism in brain derived neurotrophic factor is associated with lower BMI-SDS in children PMID: 28960774
    15. platelet BDNF and SERT do not specifically underlie psychosocial deficits in stage Huntington's Disease, while higher BDNF storage in delayed mild symptoms PMID: 30039833
    16. Direct within family analysis showed that fathers with the Met allele were more likely than Val/Val carriers to exhibit differential parenting toward twins who differed in their prosocial behavior. The same pattern of findings was found with mother-rated and experimentally assessed prosociality. PMID: 28523227
    17. The results of this study suggest that the Val66Met polymorphism does not predict long-term, functional mobility following stroke. PMID: 29480080
    18. polymorphisms in BDNF gene including rs925946, rs10501087, rs6265 and rs988712 can be considered as genetic determinants of obesity (systematic review and meta-analysis). PMID: 28818748
    19. Single nucleotide polymorphism found in the BDNF-AS (BDNF antisense RNA [nonprotein coding]) gene may be related to the decreased plasma brain derived neurotrophic factor levels found in frail elderly people. PMID: 27449141
    20. The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism; the association of a polymorphism in the BDNF gene with inflammatory markers in addition to BDNF levels suggests an interaction between these systems. PMID: 28656803
    21. Angiogenin contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF). PMID: 29573867
    22. Findings demonstrated that polymorphism Val66Met is not associated with temporal lobe epilepsy caused by hippocampal sclerosis, epilepsy-related factors and psychiatric comorbidities in this selected group of patients. PMID: 30015148
    23. Study suggested that BDNF 196 G>A polymorphism may be a genetic marker for predicting insulin resistance before initiating risperidone treatment in autism spectrum disorder patients. PMID: 29369497
    24. No significant difference was found in the BDNF Val66Met polymorphism between patients with GAD and healthy controls, nor was this polymorphism significantly associated with antidepressant drug efficacy for GAD PMID: 29446659
    25. Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults. PMID: 29525179
    26. BDNF rs11030101 and BDNF rs61888800are associated with change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment. PMID: 29310728
    27. We found that harsh parenting predicted an increased error-related negativity only among children with a methionine allele of the BDNF genotype, and evidence of moderated mediation: the ERN mediated the relationship between parenting and internalizing diagnoses and dimensional symptoms only if children had a methionine allele. PMID: 28427482
    28. Findings presented here suggest a strong influence of seasonality on depression outcome and BDNF expression in atopic dermatitis and psoriasis PMID: 27409526
    29. Serum BDNF was significantly lower in patients with Parkinson's disease than in patients with essential tremor and controls. PMID: 29350074
    30. The purpose of this systematic review was to provide a comprehensive analysis of the available clinical trials analyzing, in seniors, the effect of interval aerobic training (IAT) and continuous aerobic training (CAT) on peripheral brain-derived neurotrophic factor (BDNF) concentration. PMID: 28498065
    31. findings suggested that BDNF modulates graunlosa cell functions and the action probably mediated by FSHR-coupled signaling pathway, to affect aromatase-mediated steroidogenesis. PMID: 28282971
    32. The functional Val66Met BDNF polymorphism is not associated with BDNF serum levels in acute episode of schizophrenia and depression. PMID: 29331787
    33. This study demonstrated that a significantly higher incidence of defective BDNF expression in granule layers of the cerebellar cortex. PMID: 29174061
    34. combining cognitive and physical exercise had no additional or synergistic effect on peripheral BDNF levels compared with physical exercise alone PMID: 29842831
    35. Review/Meta-analysis: suggests a lower risk of ischemic stroke for the GG genotype of BDNF rs6265. PMID: 29449128
    36. that the BDNF SNP rs1157659 interacted with mild traumatic brain injury to predict hippocampal volume PMID: 28755387
    37. found that though there was no significantly difference in peripheral BDNF levels between ADHD patients and control groups overall, BDNF levels were significantly higher in males with ADHD compared with controls. PMID: 29132072
    38. found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression. PMID: 29102837
    39. the BDNF Val66Met polymorphism is associated with functional tuning of behaviorally-relevant frontolimbic circuitry, particularly involving the ventromedial prefrontal cortex, during higher-order learning. PMID: 28867340
    40. MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting BDNF. PMID: 29257320
    41. High expression levels of BDNF was observed in cervical cancer.BDNF role in epithelial-mesenchymal transition, migration and invasion of cervical cancer. PMID: 29345295
    42. There was a statistically significant change in BDNF levels post-chemotherapy in early-stage breast cancer patients, and plasma BDNF levels were associated with self-perceived concentration deficit in patients receiving chemotherapy. PMID: 29258453
    43. Meta-analysis/Review: patients with ischemic stroke at high risk of post stroke depression have lower BDNF levels at the early stage of stroke. PMID: 29128330
    44. Coronary artery disease patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. PMID: 29409455
    45. Brain-derived neurotrophic factor (BDNF) was found to be the downstream target of miR-107 in breast cancer. PMID: 27813254
    46. This study showed that in first-episode psychosis subjects, with global DNA hypo-methylation and reduced BDNF gene-expression. PMID: 29056292
    47. down-regulated in cord blood by prenatal smoking PMID: 28130959
    48. BDNF/TrkB axis plays a role in epithelial mesenchymal transition promoting the acquisition of (myo)fibroblast cell phenotype in idiopathic pulmonary fibrosis. PMID: 28938915
    49. Results show that Lnc RNA BDNF-AS inversely regulates the expression level of BDNF which modulates high-glucose induced apoptosis in human retinal pigment epithelial cells. PMID: 28657668
    50. This study show a linear relationship between the BDNF Val66Met genotypes and plasma BDNF levels in Caucasian depressed patients. PMID: 28848102

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  • 相關(guān)疾病:
    Bulimia nervosa 2 (BULN2); Congenital central hypoventilation syndrome (CCHS)
  • 亞細(xì)胞定位:
    Secreted.; [BDNF precursor form]: Secreted.
  • 蛋白家族:
    NGF-beta family
  • 組織特異性:
    Detected in blood plasma and in saliva (at protein level). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1033

    OMIM: 113505

    KEGG: hsa:627

    STRING: 9606.ENSP00000414303

    UniGene: Hs.502182



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