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  4. Human BMP and activin membrane-bound inhibitor homolog(BAMBI) ELISA kit

Human BMP and activin membrane-bound inhibitor homolog(BAMBI) ELISA kit

  • 中文名稱：
    人BMP激活素膜結合抑制因子同源物(BAMBI)酶聯免疫試劑盒
  • 貨號：
    CSB-EL002549HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人BMP激活素膜結合抑制因子同源物(BAMBI)酶聯免疫試劑盒（CSB-EL002549HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的BAMBI含量。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于體外培養細胞模型、動物組織樣本或生物液體中BAMBI表達水平的動態監測，為研究其在器官纖維化、腫瘤發生發展或干細胞分化等領域的分子機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    BAMBI ELISA Kit; BAMBI_HUMAN ELISA Kit; BMP and activin membrane bound inhibitor homolog ELISA Kit; BMP and activin membrane-bound inhibitor homolog ELISA Kit; NMA ELISA Kit; Non metastatic gene A protein ELISA Kit; Non-metastatic gene A protein ELISA Kit; Putative transmembrane protein NMA ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human BAMBI in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 100
    Range % 95-105
    1:2 Average % 84
    Range % 80-88
    1:4 Average % 95
    Range % 90-99
    1:8 Average % 93
    Range % 86-98
  • 回收率：
    The recovery of human BAMBI spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 89 84-93
    EDTA plasma (n=4) 97 92-101
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.324 2.495 2.410 2.286
    5 1.551 1.630 1.591 1.467
    2.5 0.950 0.904 0.927 0.803
    1.25 0.572 0.542 0.557 0.433
    0.625 0.363 0.379 0.371 0.247
    0.312 0.264 0.283 0.274 0.150
    0.156 0.224 0.216 0.220 0.096
    0 0.127 0.121 0.124 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Negatively regulates TGF-beta signaling.
  • 基因功能參考文獻：
    1. BAMBI promotes macrophage proliferation and differentiation in gliomas. PMID: 29286116
    2. These results showed that BMP2 activated SMAD1/5/8 phosphorylation and up-regulated BAMBI mRNA in human granulosa-lutein cells. PMID: 28578012
    3. Data show that BAMBI is expressed in both circulating CD4+ T cells and plasma and may be characterized as a novel immune regulator for COPD. Strikingly, BAMBI expression was significantly stronger in COPD patients and displayed strong correlations with enhanced plasma TGF-beta 1 levels and the Th17/Treg ratio. PMID: 27549738
    4. Lipopolysaccharides-mediated TLR4 signaling enhances TGF-beta response through downregulating BAMBI during prostatic hyperplasia. PMID: 27243216
    5. Low BAMB1 expression is associated with Non-Small Cell Lung Cancer. PMID: 27197161
    6. TGFbeta target genes including TGFBI, BAMBI, COL3A1 and SERPINE1 are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells PMID: 26258650
    7. The observations illuminated that BAMBI inhibits adipogenesis by a feedback loop (BAMBI-->beta-catenin nuclear translocation-->BAMBI), which forms with Wnt/beta-catenin signaling. PMID: 24798646
    8. betacatenin expression was downregulated as a result of knocking down of BAMBI, and TGF-beta was downregulated in a similar manner. PMID: 24912656
    9. BAMBI alone or in combination with Smad7 was significantly associated with the OS and DFS. These findings suggest that BAMBI and Smad7 may cooperatively inhibit the TGF-beta signaling, and thus promote the progression of gastric cancer. PMID: 24752577
    10. study demonstrates that LPS- and TNF-alpha-induced NF-kappaBp50-HDAC1 interaction represses BAMBI transcriptional activity, which contributes to TLR4-mediated enhancement of TGF-beta signaling in hepatic stellate cells during liver fibrosis. PMID: 24448807
    11. Overexpression of BAMBI is associated with the growth and invasion of human osteosarcoma. PMID: 23807684
    12. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling PMID: 22406377
    13. Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function. PMID: 22187378
    14. Data show that hepatoprotective effects of adiponectin include induction of BAMBI which is reduced in human fatty liver. PMID: 21496456
    15. BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation. PMID: 20886049
    16. Expression of the TGF pseudoreceptor BAMBI in the human lung, which is upregulated in response to nontypeable Haemophilus influenzae infection in COPD lung tissue in vivo and in vitro. PMID: 20513241
    17. Authors demonstrate for the first time a nuclear co-translocation of BAMBI with Smad2/3 upon TGF-geta treatment. Moreover, overexpression of BAMBI in an in vitro model led to significantly increased proliferation. PMID: 20189233
    18. beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI PMID: 14660579
    19. Our findings suggest that BAMBI transcription is regulated by TGF-beta signaling through direct binding of SMAD3 and SMAD4 to the BAMBI promoter. PMID: 15240101
    20. BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. PMID: 18756595
    21. BAMBI interacts with Wnt receptor Frizzled5, coreceptor LRP6, and Dishevelled2 and increases the interaction between Frizzled5 and Dishevelled2 PMID: 18838381
    22. hypermethylation of the BAMBI gene promoter that leads to BAMBI gene suppression may be one of the epigenetic events affecting the invasiveness or aggressiveness of bladder cancers PMID: 19326429
    23. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. PMID: 19328798
    24. Mechanistically, in addition to interfering with the complex formation between the type I and type II receptors, hBAMBI cooperates with Smad7 to inhibit TGF-beta signaling PMID: 19758997

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    BAMBI family
  • 組織特異性：
    High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
  • 數據庫鏈接：

    HGNC: 30251

    OMIM: 604444

    KEGG: hsa:25805

    STRING: 9606.ENSP00000364683

    UniGene: Hs.533336



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