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  4. Human Anti-Muellerian hormone type-2 receptor(AMHR2) ELISA kit

Human Anti-Muellerian hormone type-2 receptor(AMHR2) ELISA kit

  • 中文名稱：
    人抗繆勒管激素2型受體(AMHR2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL001667HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人抗繆勒管激素2型受體(AMHR2)酶聯免疫試劑盒（CSB-EL001667HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的AMHR2含量。AMHR2即抗繆勒管激素受體2，在人體生殖系統等發育中發揮重要作用。目前研究聚焦于其在卵巢癌等疾病中的機制，它可能參與細胞增殖、遷移等過程，以其為靶點有望開發新的診斷標志物和治療方法，為相關疾病防治帶來新思路。試劑盒檢測范圍為0.32 ng/mL-12 ng/mL，適用于科研領域中對AMHR2表達水平的定量分析，可用于生殖生物學研究、卵巢功能評估、性別分化機制探索及相關疾病模型的分子機制研究，為生殖系統相關蛋白的功能解析提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    AMH type II receptor ELISA Kit; AMHR ELISA Kit; AMHR2 ELISA Kit; AMHR2_HUMAN ELISA Kit; Anti Mullerian hormone receptor; type II ELISA Kit; Anti-Muellerian hormone type II receptor ELISA Kit; Anti-Muellerian hormone type-2 receptor ELISA Kit; MGC141312 ELISA Kit; MIS type II receptor ELISA Kit; MISR2 ELISA Kit; MISRII ELISA Kit; MRII ELISA Kit; Muellerian hormone type 2 receptor ELISA Kit; Muellerian hormone type II receptor ELISA Kit; Muellerian inhibiting substance type II receptor ELISA Kit; Mullerian hormone receptor type II ELISA Kit; Mullerian inhibiting substance type II receptor ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.32 ng/mL-12 ng/mL
  • 靈敏度：
    8 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<15%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human AMHR2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 92
    Range % 86-100
    1:2 Average % 95
    Range % 90-105
    1:4 Average % 92
    Range % 84-99
    1:8 Average % 96
    Range % 90-101
  • 回收率：
    The recovery of human AMHR2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 97 92-103
    EDTA plasma (n=4) 97 93-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    12 2.377 2.354 2.366 2.312
    6.4 1.726 1.742 1.734 1.680
    3.2 1.053 1.075 1.064 1.010
    0.8 0.332 0.327 0.330 0.276
    0.32 0.165 0.170 0.168 0.114
    0 0.055 0.052 0.054 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
  • 基因功能參考文獻：
    1. AMHR2 single nucleotide polymorphism is not associated with Endometriosis-associated infertility. PMID: 28831646
    2. AMHRII 1749C > T and -482A > G genetic variants are associated with the ovarian response to standard gonadotropin stimulation, affecting mainly the follicular growth in IVF. PMID: 26933946
    3. a result of VEGF misregulation, AMHR2 overexpression increases AMH binding, which may attenuate follicular or oocyte maturation. PMID: 27109000
    4. -482A > G genotype not associated with estradiol levels, ovarian parameters, menstrual cycle length, or pregnancy outcomes in healthy Singapore women PMID: 26633196
    5. A significant subset of GnRH neurons express the AMH receptor. PMID: 26753790
    6. A significant portion of AMHRII was missing most of its extracellular domain (ECD) and was unfolded and retained in the endoplasmic reticulum. PMID: 25663701
    7. study demonstrated for the first time that human placenta and fetal membranes express and co-localize Anti-Mullerian hormone(AMH) and Anti-Mullerian hormone Receptor II PMID: 25972076
    8. AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. PMID: 25790842
    9. Data indicate that Muellerian inhibiting substance type II receptor (MISRII) is a promising target for the control of ovarian granulosa cell tumors (GCT) and epithelial ovarian cancers (EOC). PMID: 25517316
    10. The possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women. PMID: 24271023
    11. Antimullerian hormone receptor expression is increased in endometrium from patients with endometriosis. PMID: 24613539
    12. Within primary ovarian insufficiency population, the AMH Ile(49)Ser and the AMHR2 -482A>G polymorphisms were not associated with age at the time of POI and PMID: 24146295
    13. The role of the AMHR2 -482 A>G gene polymorphism in the pathogenesis of polycystic ovary syndrome was suggested by the association of the variant with risk. PMID: 23969185
    14. likely molecular etiology was found in eight patients with persistent Mullerian duct syndrome. Four mutations in AMH and two in AMHR2 were identified. Three of them are novel mutations, c.556-2A>G, and p.Arg502Leu in AMH; and p.Gly323Ser in AMHR2. PMID: 23295284
    15. Data suggest that up-regulation of AMHR2 and AMH expression in luteal granulosa cells of anovulatory women with polycystic ovary syndrome is due to rising levels of luteinizing hormone (LH) and/or reversal of down-regulation by LH. PMID: 23321213
    16. The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling. PMID: 22962306
    17. the diversity of clinical symptoms within sibship and lack of correlation between development of Mullerian derivatives and severity of molecular defects suggest highly variable penetrance of abnormal alleles PMID: 22584735
    18. Association studies of common variants of AMHRII suggests that antimullerian hormone may regulate the primordial graafian follicle recruitment. PMID: 20362961
    19. Review. The role of AMHR2 in gonadal development and its mutation in the persistent Mullerian duct syndrome is discussed. PMID: 12462075
    20. binding domains recognized by a monoclonal antibody and the natural ligand PMID: 14750901
    21. The observed association of the AMHR2 -482 A > G polymorphism with natural age at menopause suggests a role for AMH signaling in the usage of the primordial follicle pool in women. PMID: 17636279
    22. MISIIR is highly expressed by a wide variety of gynecologic cancers, including cancers currently without effective systemic therapies. PMID: 17988723
    23. Reduced AMH receptor type 2 is associated with Leydig cell tumours in multiple endocrine neoplasia type 1 PMID: 18310289
    24. Non-epithelial malignant ovarian tumors showed stronger expression of anti-Mullerian hormone receptor type II than that of epithelial tumors. PMID: 19424576
    25. Mutations of AMHR2 found in persistent Mullerian duct syndrome affect its ligand binding and cellular transport. PMID: 19457927
    26. interacts with Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. PMID: 11588147

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  • 相關疾病：
    Persistent Muellerian duct syndrome 2 (PMDS2)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 數據庫鏈接：

    HGNC: 465

    OMIM: 261550

    KEGG: hsa:269

    STRING: 9606.ENSP00000257863

    UniGene: Hs.659889



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