在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Anthrax toxin receptor 2(ANTXR2) ELISA kit

  • 中文名稱:
    人炭疽毒素受體2(ANTXR2)酶聯免疫試劑盒
  • 貨號:
    CSB-EL001833HU
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人炭疽毒素受體2(ANTXR2)酶聯免疫試劑盒(CSB-EL001833HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的ANTXR2含量。ANTXR2即炭疽毒素受體2,在細胞外基質相互作用及組織發(fā)育中發(fā)揮作用。其作為炭疽毒素的結合位點被深入研究,在癌癥領域也受關注,研究發(fā)現它在腫瘤血管生成中起作用,探索其機制有望為相關疾病治療提供新思路。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL,在科研領域,本產品可用于探索炭疽毒素作用機制、受體功能研究、腫瘤微環(huán)境中宿主 - 病原體互作分析,以及動物模型中相關蛋白表達水平的動態(tài)監(jiān)測,為感染性疾病、免疫調控及細胞信號通路研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    ANTXR2; CMG2; Anthrax toxin receptor 2; Capillary morphogenesis gene 2 protein; CMG-2
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    15.6 pg/mL-1000 pg/mL
  • 靈敏度:
    3.9 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human ANTXR2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %95
    Range %90-99
    1:2Average %90
    Range %84-100
    1:4Average %92
    Range %85-102
    1:8Average %92
    Range %89-98
  • 回收率:
    The recovery of human ANTXR2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9586-106
    EDTA plasma (n=4)9187-95
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.293 2.325 2.309 2.102
    5001.604 1.629 1.617 1.410
    2501.142 1.101 1.122 0.915
    1250.696 0.711 0.704 0.497
    62.50.492 0.503 0.498 0.291
    31.20.351 0.362 0.357 0.150
    15.60.282 0.271 0.277 0.070
    00.205 0.208 0.207
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Necessary for cellular interactions with laminin and the extracellular matrix.; (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm.
  • 基因功能參考文獻:
    1. A decreased CMG2 expression is a negative prognostic factor for soft tissue sarcoma patients. PMID: 29215551
    2. Results identified Gly116Val mutation in ANTXR2 associated with hyaline fibromatosis syndrome. PMID: 28103792
    3. Stability of domain 4 of the anthrax toxin protective antigen and the effect of the VWA domain of CMG2 on stability PMID: 27874231
    4. study examines 4 cases with clinical features of hyaline fibromatosis syndrome; identified a previously unreported splice junction mutation (c.946-2A-->G in intron 11) and a recurrent founder mutation ( c.1074delT) PMID: 27174544
    5. This study reports a novel association between ANTXR2 and ankylosing spondylitis in the Han Chinese. PMID: 26728147
    6. Case Report: systemic hyalinosis with a heterozygous mutation in CMG2. PMID: 26885603
    7. The association between ANTXR2 rs4333130 and ankylosing spondylitis was independent of HLA-B27 status. Clinical disease severity scores (BASDAI and BASFI) and pain score were higher in ANTXR2 rs4333130 CT genotype. PMID: 26590821
    8. Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation PMID: 26805886
    9. Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression PMID: 26703731
    10. miR-124 might induce autophagy to participate in AS by targeting ANTXR2, which might be implicated in pathological process of AS. PMID: 25736362
    11. The disulfide bond Cys255-Cys279 in the immunoglobulin-like domain of ANTXR2 is required for membrane insertion of anthrax protective antigen pore. PMID: 26107617
    12. CMG2 glycosylation provides a buffer towards genetic variation by promoting folding of the protein in the ER lumen. PMID: 25781883
    13. Results show that CMG2 has been shown to be able to regulate the proliferation and tubule formation of endothelial cells, but not the migration. PMID: 24993339
    14. Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene. PMID: 25169729
    15. data suggested that cellular cholesterol regulated ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell. PMID: 24924630
    16. Fused the ANTXR2 ectodomain to the C-terminus of bacterial Trigger Factor (TF), and the fusion protein was overly expressed as a dominant soluble protein in E coli. PMID: 24380801
    17. Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages. PMID: 24742682
    18. Loss of CMG2 expression is associated with breast cancer progression. PMID: 24667935
    19. A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation PMID: 24641616
    20. Investigated the kinetics of binding as a function of pH to the full-length monomeric anthrax protective antigen(PA)and to two variants to CMG2. Results suggest that for the full-length PA, low pH increases the binding affinity. PMID: 22855243
    21. 2 novel ANTXR2 mutations were identified in patients with hyaline fibromatosis syndrome PMID: 22383261
    22. ANTXR2 and IL-1R2 polymorphisms are not associated with ankylosing spondylitis in Chinese Han population. PMID: 20652271
    23. results reveal extensive diversity in cell lethality dependent on anthrax toxin PA-mediated toxin binding and uptake, and identify individual differences in CMG2 expression level as a determinant of this diversity PMID: 22315420
    24. ANTXR2 might not be a susceptibility gene of Ankylosing Spondylitis in Chinese Han. PMID: 22118297
    25. Missense mutations in the extracellular von Willebrand domain of CMG2 lead to protein folding defects. PMID: 21328543
    26. the molecular basis (spectrum of ANTXR2 mutations) of infantile systemic hyalinosis and juvenile hyaline fibromatosis in two unrelated Egyptian families PMID: 20331448
    27. Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding. PMID: 17183731
    28. Cytoplasmic delivery of lethal factor by anthrax toxin receptor 2 was mediated by cathepsin B. PMID: 19858192
    29. identification and characterization of juvenile hyaline fibromatosis and infantile systemic hyalinosis disease-causing mutations in the capillary morphogenesis factor-2 gene PMID: 12973667
    30. identification of 15 different mutations in the gene encoding capillary morphogenesis protein 2 in 17 families with juvenile hyaline fibromatosis or infantile systemic hyalinosis PMID: 14508707
    31. structures provide a template to begin probing the high-affinity capillary morphogenesis protein 2-protective antigen interaction and may facilitate understanding of toxin assembly/internalization PMID: 15079089
    32. crystal structure of the complex with anthrax toxin PMID: 15243628
    33. Molecular dynamics simulations explain the great strength that the protective antigen-capillary morphogenesis gene 2 complex achieves through extraordinary coordination of a divalent cation. PMID: 16473908
    34. Results suggest that, in vivo, slow folding, rather than misfolding, is responsible for ER retention, and that systemic hyalinosis can be qualified as a conformational disease. PMID: 19191226

    顯示更多

    收起更多

  • 相關疾病:
    Hyaline fibromatosis syndrome (HFS)
  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族:
    ATR family
  • 組織特異性:
    Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • 數據庫鏈接:

    HGNC: 21732

    OMIM: 228600

    KEGG: hsa:118429

    STRING: 9606.ENSP00000306185

    UniGene: Hs.162963



主站蜘蛛池模板: 精品夜夜澡人妻无码av| 国产成人av在线播放影院| 最新精品国偷自产在线老年人| 久久99热只有频精品8| 久久久久蜜桃精品成人片公司 | 中文字幕人妻互换av久久| 久久妇女高潮喷水多| 久久天天躁夜夜躁狠狠躁2022| 欧美品无码一区二区三区在线蜜桃 | www亚洲精品久久久| 亚洲精品无码成人片久久| 久久久久人妻一区精品| 无码成人一区二区三区| 国产特级毛片aaaaaa| 凸偷窥中国女人洗澡| 日韩精品少妇无码受不了| 精品人无码一区二区三区| 久久中文字幕人妻熟av女蜜柚m| 琪琪电影午夜理论片八戒八戒| 亚洲综合久久无码色噜噜赖水| 在线精品亚洲一区二区小说| 国产成人无码精品久久久露脸| 18禁美女裸体免费网站| 国产一区二区野外| 国产萌白酱喷水视频在线播放| 97久久超碰中文字幕| 欧美日韩在线视频一区| 亚洲中文字幕无码一区二区三区| 欧美精品亚洲精品日韩专区va| 亚洲免费网站观看视频| 亚洲熟妇无码av不卡在线| 草草影院发布页| 无套熟女av呻吟在线观看| 国产成人精品日本亚洲999| 精品久久人妻av中文字幕| 国产精品久久久久av福利动漫| 97成人碰碰久久人人超级碰oo| 人摸人人人澡人人超碰97| 欧美xxxx做受性欧美88| 九月婷婷人人澡人人添人人爽| 国精品人妻无码一区免费视频电影|