在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human Anterior gradient protein 3 homolog(AGR3) ELISA kit

Human Anterior gradient protein 3 homolog(AGR3) ELISA kit

  • 中文名稱：
    人前梯度蛋白3同源物(AGR3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL001459HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人前梯度蛋白3同源物(AGR3)酶聯(lián)免疫試劑盒（CSB-EL001459HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的AGR3含量。AGR3是一種與促癌基因AGR2高度相關(guān)的同源蛋白，屬于蛋白質(zhì)二硫鍵異構(gòu)酶家族。它在乳腺癌、卵巢癌、前列腺癌和肝癌中表達(dá)，與腫瘤的分化程度、增殖速度和預(yù)后相關(guān)。研究顯示，AGR3在乳腺癌患者中表達(dá)與更長的無進(jìn)展生存期和更好的預(yù)后相關(guān)。其具體作用機(jī)制尚在研究中，但可能與蛋白質(zhì)折疊和巰基-二硫化物交換反應(yīng)有關(guān)。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，本試劑盒可應(yīng)用于科研領(lǐng)域中對AGR3蛋白表達(dá)量的精準(zhǔn)檢測，適用于腫瘤發(fā)生機(jī)制研究、疾病相關(guān)分子標(biāo)志物篩選、藥物干預(yù)效果評估等實(shí)驗(yàn)場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    AG-3 ELISA Kit; AG3 ELISA Kit; Agr3 ELISA Kit; AGR3_HUMAN ELISA Kit; Anterior gradient 3; xenopus; homolog of ELISA Kit; Anterior gradient homolog 3 ELISA Kit; Anterior gradient homolog 3 (Xenopus laevis) ELISA Kit; anterior gradient protein 3 ELISA Kit; Anterior gradient protein 3 homolog ELISA Kit; BCMP11 ELISA Kit; Breast cancer membrane protein 11 ELISA Kit; Gm888 ELISA Kit; hAG 3 ELISA Kit; hAG-3 ELISA Kit; HAG3 ELISA Kit; OTTHUMP00000158512 ELISA Kit; PDIA18 ELISA Kit; Protein disulfide isomerase family A member 18 ELISA Kit
  • 縮寫：
    AGR3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human AGR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %85
    Range %80-89
    1:2Average %91
    Range %86-95
    1:4Average %94
    Range %90-98
    1:8Average %97
    Range %92-101
  • 回收率：
    The recovery of human AGR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9085-95
    EDTA plasma (n=4)9489-99
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.713 2.662 2.688 2.515
    52.376 2.431 2.404 2.231
    2.51.934 2.001 1.968 1.795
    1.251.509 1.582 1.546 1.373
    0.6250.974 1.020 0.997 0.824
    0.3120.564 0.559 0.562 0.389
    0.1560.296 0.279 0.288 0.115
    00.178 0.167 0.173 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
  • 基因功能參考文獻(xiàn)：
    1. Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC. PMID: 29620196
    2. transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A PMID: 25868611
    3. Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer. PMID: 25875093
    4. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. PMID: 25751668
    5. Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. PMID: 25666661
    6. AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma PMID: 24747240
    7. AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression. PMID: 22361111
    8. AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. PMID: 21451362
    9. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein] PMID: 12592373
    10. specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members PMID: 15935701

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    AGR family
  • 組織特異性：
    Expressed in the lung, in the ciliated cells of the airway epithelium. Expression increased with differentiation of airway epithelial cells. Not detected in the mucous cells. Expressed in ciliated cells in the oviduct. Also detected in stomach, colon, pro
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24167

    OMIM: 609482

    KEGG: hsa:155465

    STRING: 9606.ENSP00000308606

    UniGene: Hs.100686



主站蜘蛛池模板： 无码人妻一区二区三区免费看成人 | 日韩av无码社区一区二区三区| 国产极品久久久久久久久| 亚洲综合激情另类专区| 成年美女黄网站色大免费视频| 欧美成人一区二区三区| 果冻传媒2021精品一区| 亚洲人成色77777在线观看大战| 下面一进一出好爽视频| 亚洲国产精品久久人人爱| 亚洲熟少妇在线播放999| 高潮潮喷奶水飞溅视频无码 | 日产精品卡二卡三卡四卡区满十八 | 999国产精品999久久久久久| www国产亚洲精品久久| 亚洲精品无码永久中文字幕| 国产边打电话边被躁视频| 性欧美老人牲交xxxxx视频| 精品国产一区二区三区麻豆| 中文字幕久久久久人妻| 免费国偷自产拍精品视频| 天堂网www中文在线 | 无码国内精品久久人妻 | 亚洲性猛交xxxx| 久久久婷婷五月亚洲97号色| 亚洲国产欧美国产综合久久 | 久久九九兔免费精品6| 亚洲另类欧美综合久久图片区| 色狠狠成人综合网| 天堂网在线最新版www中文网| 狠狠做久久深爱婷婷| 久久久久国产精品熟女影院| 一本加勒比hezyo无码资源网| 欧美506070老妇乱子伦| 天干天干啦夜天干天天爽| 欧美丰满熟妇xxxx性大屁股| 国产成+人+综合+亚洲欧美丁香花 欧美性黑人极品hd另类 | 伊人久久大香线蕉亚洲五月天 | 国产欧美日韩专区发布 | 波多野成人无码精品电影| 色妺妺在线视频|