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中文名稱:人血管生成素1(ANGPT1)酶聯免疫試劑盒
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貨號:CSB-EL001706HU
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規格:96T/48T
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價格:¥3600/¥2500
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其他:
產品詳情
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產品描述:人血管生成素1(ANGPT1)酶聯免疫試劑盒(CSB-EL001706HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、組織培養上清液樣本中的ANGPT1含量。ANGPT1是一個重要靶點。它在血管生成、維持血管穩定等生理過程中發揮關鍵作用。其研究機制主要圍繞與受體結合,激活下游信號通路,調控內皮細胞行為。深入了解它有助于揭示相關疾病發病機制,并為開發治療藥物提供理論依據。試劑盒檢測范圍為1.25 ng/mL-80 ng/mL,靈敏度為0.091 ng/mL。適用于血管生物學機制研究、腫瘤微環境分析、心血管疾病模型構建等科研場景,可幫助研究者探索ANGPT1在血管生成異常、炎癥反應或器官纖維化等病理過程中的表達調控規律,為體外實驗或動物模型中的血管相關研究提供可靠的數據支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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縮寫:
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates, cell culture supernates
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檢測范圍:1.25 ng/mL-80 ng/mL
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靈敏度:0.091 ng/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Cardiovascular
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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線性度:
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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標準曲線:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
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數據處理:
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貨期:3-5 working days
引用文獻
- Hormone Receptor‐Dependent Correlations Between Angiopoietins and VEGF‐C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers V Montazeri, P Varshosaz, A Fakhrjou,Cancer Reports,2025
- The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients Pirouzpanah S, et al,Scientific Reports,2019
靶點詳情
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最新研究進展:最近的研究表明,ANGPT1在調節血管通透性和血管生成方面發揮著重要作用。它的缺失可能導致血管滲漏和心血管疾病等疾病的發生。最近的研究還發現,ANGPT1可以作為一種潛在的治療靶點,用于治療多種疾病,如腫瘤、心血管疾病和腎病等。
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功能:Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
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亞細胞定位:Secreted.
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數據庫鏈接:
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