在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human A disintegrin and metalloproteinase with thrombospondin motifs 18(ADAMTS18) ELISA kit

  • 中文名稱:
    人金屬肽酶含血小板反應(yīng)蛋白18(ADAMTS18)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL001306HU
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人金屬肽酶含血小板反應(yīng)蛋白18(ADAMTS18)酶聯(lián)免疫試劑盒(CSB-EL001306HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的ADAMTS18含量。ADAMTS18屬于ADAMTS蛋白酶家族,參與細(xì)胞外基質(zhì)的代謝和組織重塑。研究表明,它在多種生理和病理過程中發(fā)揮作用,如血管生成、腫瘤進(jìn)展等。其機制可能涉及對特定底物的蛋白水解切割,不過關(guān)于它的確切功能和作用機制仍在進(jìn)一步研究中。試劑盒檢測范圍為0.016ug/ml- 10ug/ml,支持科研領(lǐng)域?qū)DAMTS18蛋白表達(dá)的定量分析,適用于癌癥生物學(xué)研究、組織微環(huán)境調(diào)控、胚胎發(fā)育或疾病模型構(gòu)建等方向,為探索ADAMTS18在細(xì)胞遷移、血管形成或腫瘤轉(zhuǎn)移中的作用機制提供可靠工具本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    ADAMTS18 ELISA kit; ADAMTS21A disintegrin and metalloproteinase with thrombospondin motifs 18 ELISA kit; ADAM-TS 18 ELISA kit; ADAM-TS18 ELISA kit; ADAMTS-18 ELISA kit; EC 3.4.24.- ELISA kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.016ug/ml- 10ug/ml
  • 靈敏度:
    0.016ug/ml
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cell Biology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn):
    1. In summary, we demonstrate that ADAMTS18 silencing in breast cancer is significantly correlated with promoter CpG methylation. ADAMTS18 acts as an antagonist of AKT and NF-kappaB signaling, further suppressing EMT and metastasis of breast cancer cells. PMID: 28503860
    2. This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) PMID: 28814085
    3. Studies suggest that ADAM metallopeptidase with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target. PMID: 24896365
    4. Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers PMID: 24874986
    5. Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia. PMID: 23818446
    6. study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases PMID: 23356391
    7. the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation. PMID: 21862674
    8. ADAMTS18 mutations promote growth, migration, and metastasis in melanoma PMID: 21047771
    9. ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis. PMID: 19806480
    10. Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas. PMID: 17546048
    11. ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. PMID: 19249006

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT)
  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性:
    Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17110

    OMIM: 607512

    KEGG: hsa:170692

    STRING: 9606.ENSP00000282849

    UniGene: Hs.188746



主站蜘蛛池模板: 一本久久知道综合久久| 亚洲综合另类小说色区色噜噜| 丰满熟女高潮毛茸茸欧洲视频 | 国产萌白酱喷水视频在线播放| 国产国产裸模裸模私拍视频| 日韩av高清在线看片| 欧美熟妇另类久久久久久多毛| 少妇人妻上班偷人精品视频| 亚洲成a人片在线观看天堂无码不卡| 成人免费无码大片a毛片小说| 无码国产精品一区二区免费i6 | 爆乳高潮喷水无码正在播放| 精品av综合导航| 黑人巨茎美女高潮视频| 精品无码一区二区三区电影| 久久久国产精品va麻豆| aⅴ亚洲 日韩 色 图网站 播放 | 国产亚洲精品久久久久动漫| 天堂va欧美ⅴa亚洲va在线| 精品1卡二卡三卡四卡老狼| 国产又色又爽又黄又免费软件| 一区二区视频传媒有限公司| 国产免费网站看v片在线无遮挡| 国产成人综合在线视频| 精品人妻少妇一区二区三区在线 | 国产精品特黄aaaa片在线观看| 男男又爽又黄又无遮挡网站| 久人人爽人人爽人人片av| 日本道色综合久久影院| 欧美人与善在线com| 夜夜躁狠狠躁日日躁视频| 久久伊人五月丁香狠狠色| 丁香五月婷激情综合第九色| 久久激情五月丁香伊人| 国产伦理一区二区| 中文字幕久久综合伊人| 亚洲成亚洲成网| 好男人社区在线www| 国产猛男猛女超爽免费视频 | 国产亚洲人成无码网在线观看| 国产成人无码一区二区在线播放|