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Human α-subunits of hemoglobin(HB-α) ELISA Kit

  • 中文名稱:
    人血紅蛋白α亞基(HB-α)酶聯免疫試劑盒
  • 貨號:
    CSB-E13105h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人血紅蛋白α亞基(HB-α)酶聯免疫試劑盒(CSB-E13105h)為競爭法ELISA試劑盒,定量檢測血清、血漿、RBC裂解物樣本中的HBA1含量。HBA1編碼成人血紅蛋白的α亞基,在氧氣運輸等生理過程中至關重要。其異常與多種血紅蛋白病相關。研究主要聚焦基因變異對蛋白結構和功能的影響,以揭示疾病發病機制,為開發針對性診斷方法和治療策略提供依據。試劑盒檢測范圍為0.170 ng/mL-700 ng/mL,適用于體外培養紅細胞研究、血紅蛋白合成調控實驗、溶血性貧血動物模型評估等科研場景;滿足基礎研究與轉化醫學中對HB-α蛋白定量分析的需求,為探索血液相關疾病的分子機制提供可靠工具本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Alpha 1 globin ELISA Kit; Alpha globin ELISA Kit; Alpha one globin ELISA Kit; Alpha-globin ELISA Kit; HBA_HUMAN ELISA Kit; HBA1 ELISA Kit; HBA2 ELISA Kit; Hemoglobin alpha 1 ELISA Kit; Hemoglobin alpha 1 chain ELISA Kit; Hemoglobin alpha 1 globin chain ELISA Kit; Hemoglobin alpha 2 ELISA Kit; Hemoglobin alpha chain ELISA Kit; Hemoglobin subunit alpha ELISA Kit; MGC126895 ELISA Kit; MGC126897 ELISA Kit
  • 縮寫:
    HBA2
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, lysate for RBC
  • 檢測范圍:
    0.170 ng/mL-700 ng/mL
  • 靈敏度:
    0.17 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Competitive
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human HB-α in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)
    1:100 Average % 93
    Range % 84-103
    1:200 Average % 91
    Range % 85-99
    1:400 Average % 95
    Range % 85-103
    1:800 Average % 91
    Range % 83-98
  • 回收率:
    The recovery of human HB-α spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 88-101
    EDTA plasma (n=4) 95 87-102
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average
    700 0.248 0.252 0.250
    175 0.441 0.435 0.438
    44 0.528 0.514 0.521
    11 0.712 0.723 0.718
    2.7 0.867 0.861 0.864
    0.7 1.119 1.107 1.113
    0.17 1.738 1.716 1.727
    0 1.935 1.922 1.929
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Involved in oxygen transport from the lung to the various peripheral tissues.
  • 基因功能參考文獻:
    1. Relatively high but clinically normal HbA1c and TSH levels may increase the risk of CHD. PMID: 28345646
    2. Vaginal cell-derived Hb-alpha and Hb-beta may have antioxidative properties and protect cells from oxidative stress-induced inflammation possibly through Nrf2 downstream signaling. PMID: 28224676
    3. Data suggest that, in crystal form of Hb containing three protein molecules--Hbalpha(1)beta(2), allosteric effectors (phosphate, bezafibrate) induce conformational changes in direction from relaxed-state to tense-state; binding of each effector energetically stabilizes lowest affinity conformer more strongly than intermediate affinity conformer; minor Hb conformers have disproportionate effects on overall O(2) affinity. PMID: 28931607
    4. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA PMID: 26995402
    5. genome-wide association meta-analyses in individuals from 82 cohorts of European, African, East Asian and South Asian ancestry; identified 60 common genetic variants associated with HbA1c; 19 glycemic (GS-G) and 22 erythrocytic (GS-E) variants were associated with HbA1c at genome-wide significance; GS-G was associated with higher type 2 diabetes risk; GS-E was not PMID: 28898252
    6. This study presents comparison of two neutron structures of hemoglobins, human deoxyhemoglobin (T state) and equine cyanomethemoglobin (R state) and offers a direct observation of histidine residues that are likely to contribute to the Bohr effect. PMID: 27377386
    7. Dynamical differences of hemoglobin and the ionotropic glutamate receptor in different states have been revealed by a new dynamics alignment method. PMID: 28459140
    8. The studies suggest that impaired endocytosis of megalin/cubilin ligands, hemoglobin and albumin, rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients. PMID: 28356267
    9. Report association between HbA1c levels in diabetes mellitus type 2 in relation to the development of heart failure. PMID: 27647169
    10. Lower extremity amputation among patients with diabetes nearly halved over the past decade but only weakly correlated with hemoglobin A1c testing throughout the study period. PMID: 27206471
    11. A 1 % increase in HbA1c was associated with a higher risk for all-cause mortality in patients with type 2 diabetes and symptomatic cardiovascular disease PMID: 27431507
    12. 14 alpha thalassemia mutations were found among 95 Turkish patients. Most were gene deletions. A new alpha 1 cd 14 mutation was discovered. PMID: 26377141
    13. The hematological and molecular data of 35 patients with Hb H disease and the genotypes of alpha-gene mutations of 78 screened individuals were used to identify the genotypes of Hb H disease and genotype-phenotype correlations. the most common genotypes were -alpha3.7/--20.5, -alpha3.7/--26.5, and -alpha3.7/--17.5. Other small deletions, non-deleltional mutations, and combinations thereof in trans were associated with... PMID: 26316481
    14. that there is a quantitative relationship between the HbA1c levels and plaque textures in ultrasonic images of atherosclerotic patients PMID: 27431674
    15. An association has been found between the TXNIP gene methylation pattern and type 2 diabetes mellitus in ischemic stroke patients through epigenetic mechanisms, related to sustained hyperglycemia levels with HbA1c >/= 7%. PMID: 26643952
    16. People with new-onset diabetes mellitus based on HbA1c had higher mean hs-CRP level. PMID: 26824043
    17. This study describes hematological manifestations of subjects carrying some novel mutations comparable to the reported phenotype of alpha(+)-thal trait. PMID: 26531168
    18. The effect of the DPP-4 inhibitor alogliptin on HbA1c. PMID: 26125284
    19. Data suggest considering HbA1c as a reliable marker of cardiovascular and metabolic risk independent of fasting and post-load glycemia. PMID: 26520892
    20. Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic peritoneal dialysis patients. PMID: 26239161
    21. The most deleterious non-coding synonymous SNPs in the alpha-thalassemia HBA1 gene have been characterized in silico. PMID: 26824843
    22. The carrier rate of Hb Q-Thailand in Guangxi was 0.06%. PMID: 27060306
    23. In multivariable linear regression analyses, DeltaGA/HbA1c was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time. PMID: 26484352
    24. Poorer glucose control with HbA1C >/= 8% and decreased systolic heart function are significant risk factors that potentially contribute to worse prognosis for CABG or PCI treatment. PMID: 26261612
    25. In middle-aged Caucasian-Europeans, HbA1c alone is a poor indicator of cardiometabolic risk but is suitable for diagnosing diabetes. PMID: 26266799
    26. The lack of association between known risk factors for diabetes and HbA1c suggest that HbA1c in children without diabetes is relatively unaffected by factors associated with glycaemia. PMID: 25875773
    27. Data indicate that amplification, detection and analysis of targets in the alpha-globin genes (HBA1 and HBA2) by ratio assay copy enumeration (GRACE) PCR method completed within one hour. PMID: 26683685
    28. In a chronic kidney disease cohort, HbA1c values in the prediabetes range are associated with mortality. PMID: 25979978
    29. Both HbA1c and glycated albumin levels reflect the risk of subclinical atherosclerosis in middle-aged and elderly Chinese with impaired glucose regulation. PMID: 25854289
    30. Increase of HbA1c in patients with newly detected glucose abnormalities was associated with significantly reduced survival after AMI treated invasively. PMID: 24618476
    31. Co-inheritance of novel ATRX gene mutation and alpha-globin/beta-globin gene mutations has been found in transfusion dependent beta-thalassemia Saudi Arabia patients. PMID: 25976463
    32. Elevated mean platelet volume is significantly associated with higher HbA1c levels. PMID: 25249479
    33. HbA1c has a role in increased risk of cardiovascular disease and all-cause death PMID: 25874454
    34. In non-diabetic patients with suspected stable angina pectoris, there was no overall association between HbA1c levels and prognosis. PMID: 25770690
    35. Insulin-naive diabetic patients with A1C>8.8%, especially those who are taking >2 oral antidiabetic agents, have small chance to achieve good glycemic control with adding only basal insulin therapy. PMID: 25266893
    36. Although A1C is higher among type 2 diabetics with CKD stage 3 compared to those with eGFR >/=60, this appeared to be due to the confounding effect of other variables rather than the presence of CKD. PMID: 24893965
    37. Higher fasting plasma glucose levels rather HbA1c were strongly predictive of future hypertension among Japanese population. PMID: 25231510
    38. alpha1 gene sequencing showed the mutation CCT-->TCT (Pro-->Ser) at codon 119 (Hb Groene Hart) in alpha-thalassemia patients in Spain. In one case, there was an association with Hb J-Paris-I. PMID: 24530052
    39. With the corrections proposed here, HbA1c measurements can be better interpreted as a diagnostic marker in the early weeks of antidiabetic treatment. PMID: 25158164
    40. A new Hb variant was found in 4 diabetic patients. The alpha1 gene had a mutation GAC>AAC at codon 64 within exon 2. Substituting Asn for Asp does not produce any functional alteration, so it is a silent hemoglobinopathy. PMID: 25458507
    41. Overall postoperative complication rate was similar regardless of preoperative HbA1c in pancreaticoduodenectomy patients, but pancreatic fistula incidence was lower with elevated versus normal HbA1c. PMID: 25242683
    42. the first described case with homozygosity for the Hb Adana mutation, carried on the alpha1 gene. The relatively mild presentation of the case highlights the milder phenotypic consequences of nondeletional alpha mutations in the alpha1 vs. the alpha2 gene. PMID: 25342395
    43. Abnormal hemoglobin with alpha-thalassemia may lead to severe anemia. PMID: 25863092
    44. Data suggest co-inheritance of alpha-globin mutation/alpha-thalassemia alleviates severity of HBE-type beta-thalassemia in population of children/adolescents in Thailand; beta-thalassemia patients who co-inherited alpha-thalassemia had mild disease. PMID: 25238043
    45. Hemoglobin A1C and glycemic variability were both associated with beta cell function in patients with newly diagnosed type 2 diabetes. PMID: 24762059
    46. Data suggest two alpha-thalassemia patients and their family members exhibiting HbH disease spectrum exhibit two rare and unique alpha-globin gene cluster deletions (deletion of HBA1 and HBA2); families are described as Israeli Arabs. [CASE-REPORT] PMID: 25222045
    47. Data suggest hemoglobin glycation in diabetic patients and normal subjects is consistent; seven glycation sites have been unambiguously assigned in alpha- and beta-globin; the two major sites are alpha-Lys-61 (HbA1c) and beta-Lys-66. PMID: 24578002
    48. Elevated preoperative hemoglobin A1c levels are associated with an increased risk of readmission but not complications. PMID: 24887924
    49. Presented are complete structural and functional snapshots of nine equilibrium conformers of hemoglobin in the half-liganded and fully liganded states. Captured is the hemoglobin allosteric transition in a single crystal form. PMID: 24635037
    50. HbA1c levels lower than 6.0% and higher than 10% are associated with an increased risk of COPD in patients with type 2 diabetes. PMID: 25569658

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  • 相關疾病:
    Heinz body anemias (HEIBAN); Alpha-thalassemia (A-THAL); Hemoglobin H disease (HBH)
  • 蛋白家族:
    Globin family
  • 組織特異性:
    Red blood cells.
  • 數據庫鏈接:

    HGNC: 4823

    OMIM: 140700

    KEGG: hsa:3039

    STRING: 9606.ENSP00000322421

    UniGene: Hs.449630



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