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Dog clusterin,CLU ELISA Kit

  • 中文名稱:
    犬凝聚素(CLU)酶聯免疫試劑盒
  • 貨號:
    CSB-E13770c
  • 規格:
    96T/48T
  • 價格:
    ¥4200/¥3000
  • 其他:

產品詳情

  • 產品描述:
    犬凝聚素(CLU)酶聯免疫試劑盒(CSB-E13770c)為競爭法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的CLU含量。CLU是一個備受關注的靶點。它在多種生理和病理過程中發揮作用,如細胞凋亡、脂質代謝等。研究機制方面,主要聚焦其在疾病中的表達變化及作用途徑,探索通過調控CLU來干預疾病,為相關治療提供新的思路和靶點。試劑盒檢測范圍為7.813 ng/mL-500 ng/mL,靈敏度為4.963 ng/mL。該產品適用于探索犬類疾病模型中CLU蛋白的表達動態,例如通過分析血清或血漿樣本評估循環系統中CLU的濃度變化,或利用組織勻漿研究特定病理狀態下CLU的局部表達特征,為神經科學、腫瘤生物學及炎癥相關機制研究提供工具支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CLUClusterin ELISA kit; Glycoprotein 80 ELISA kit; Gp80) [Cleaved into: Clusterin beta chain; Clusterin alpha chain] ELISA kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    7.813 ng/mL-500 ng/mL
  • 靈敏度:
    4.963 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Competitive
  • 數據處理:
  • 貨期:
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 最新研究進展:
    CLU(也稱為apoJ)是一種高度保守的糖蛋白,廣泛存在于多種細胞類型和組織中。CLU參與了多種生物學過程,包括細胞凋亡、炎癥、脂代謝和細胞遷移等。最近的研究表明,CLU與多種疾病的發生和發展有關,如癌癥、心血管疾病、神經系統疾病和肝病等。此外,CLU還可能作為生物標志物來評估某些疾病的診斷和預后。
     
  • 功能:
    Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3. Plays a role in the clearance of immune complexes that arise during cell injury.
  • 基因功能參考文獻:
    1. Real time RT-PCR and western blotting analysis indicated there was a greater abundance of clusterin in cryptorchid dog testes. Furthermore, clusterin was detected in extracellular regions of cryptorchid dog testes. PMID: 29678567
    2. Clusterin may potentially serve as a marker for chronic spinal cord disease in the dog. PMID: 23990410
    3. The chaperone action of clusterin targets prefibrillar species to inhibit amyloid formation PMID: 17412999
    4. The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress PMID: 17451556
    5. The chaperone action of clusterin is important in quality control of extracellular protein folding PMID: 19878774
    6. The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins PMID: 21505792
    7. Clusterin is an extracellular holdase-type chaperone PMID: 10066740
    8. The chaperone action of clusterin is like that of the small heat shock proteins PMID: 10694874
    9. The chaperone action of clusterin is independent of ATP PMID: 11123922
    10. Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner. PMID: 20813109

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  • 亞細胞定位:
    Secreted. Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrion membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule.
  • 蛋白家族:
    Clusterin family
  • 數據庫鏈接:


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