在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat C-C motif chemokine 3 protein (Ccl3)

In Stock
  • 中文名稱:
    Recombinant Rat C-C motif chemokine 3 protein(Ccl3) (Active)
  • 貨號:
    CSB-AP001521RA
  • 規(guī)格:
    ¥852
  • 圖片:
  • 其他:

產(chǎn)品詳情

  • 純度:
    >98% as determined by SDS-PAGE.
  • 內(nèi)毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using human blood monocytes is in a concentration range of 10-100 ng/ml.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ccl3; Mip1a; Scya3; C-C motif chemokine 3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.Coli
  • 分子量:
    7.9 kDa
  • 表達(dá)區(qū)域:
    24-92aa
  • 氨基酸序列
    APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA
  • 蛋白標(biāo)簽:
    Tag-Free
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
  • 基因功能參考文獻(xiàn):
    1. The important chemokine macrophage inflammatory protein1alpha increases inflammatory responses and the secretion of inflammatory molecules from Kupffer cells, including tumor necrosis factoralpha, interleukin (IL)1beta and IL6. PMID: 28677732
    2. The present report demonstrates an increase in mRNA and protein levels in chemokines CCL3 and its receptor CCR5 in dorsal root ganglion in the rat model of remifentanil-induced hyperalgesia. Furthermore, the results pointed out that CCL3 and its receptor CCR5 might be implicated in remifentanil-induced hyperalgesia. PMID: 26550961
    3. Study shows that erythropoietin reduced chemokine CCL3 mRNA expression in rat cerebellar neuron-enriched preparations during neuroinflammation. PMID: 26178913
    4. The results of this study suggest a contribution of CCL3 in the spinal dorsal horn to paclitaxel-induced allodynia and may provide new therapeutic targets for paclitaxel-induced painful neuropathy. PMID: 25127716
    5. Expression levels of CCL3 in the spinal cord are up-regulated following nerve injury. PMID: 24589480
    6. NMDA-evoked neuronal injury differentially induces MIP-1alpha and MCP-1 production in microglia and astrocytes, respectively, through activation of different intracellular signaling pathways. PMID: 22791363
    7. Our data suggest that free radicals produced in CA1 neurons contribute to the recruitment and activation of microglia and neurodegeneration through MIP-1alpha expression. PMID: 18272692
    8. In this study we present data on long term increase in CCL3 mRNA expression and immunoreactivity following epileptogenic stimulus in a rat model of temporal lobe epilepsy. PMID: 21731074
    9. Data show significant concentration increases for CXCL1 and MIP-1alpha in the brain after soman-induced seizure onset. PMID: 21535896
    10. The active behavior of the MIP-1alpha gene in KCs following liver ischemia/reperfusion injury is assumed to be one of the major causes for the hepatic ischemia/reperfusion injury. PMID: 16804970
    11. P2Y6 activation by uridine 5'-diphosphate induces Ccl2 and Ccl3 expression in primary cultured microglia, astrocytes, and brain slices from neonatal and adult rats. PMID: 21317391
    12. a massive amount of ATP molecules released in the glioma tumor site may act as the regulator with P2XR signaling that increases MIP-1alpha and MCP-1 expression in tumor-infiltrating microglia/macrophages. PMID: 21162127
    13. These results suggest that MIP-1alpha is directly involved in the neurodegeneration induced in rats by PVC-211 murine leukemia virus by recruiting macrophages/microglia from the periphery into regions of the brain that eventually become diseased. PMID: 21051067
    14. expression is regulated by nicotine in alveolar macrophages PMID: 12101081
    15. The constitutive patterns of MIP-1 alpha mRNA and protein expression are demonstrated in rat brain throughout postnatal development within local microenvironments where the postnatal cell migration phenomenon occurs. PMID: 12899200
    16. Oligodendroglia express the CCL3 receptor CCR1, but not CCR5. CCL3 induced an intracellular rise in Ca(2+), a typical signalling event of G protein-coupled receptors. PMID: 14583384

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 天堂va欧美ⅴa亚洲va在线| 亚洲一区二区三区高清av| 亚洲欧洲专线一区| 无码精品a∨在线观看无广告| av无码人妻一区二区三区牛牛| 少妇被黑人4p到惨叫欧美人| 国产精品一区在线观看你懂的| 日韩精品成人无码专区免费| 亚洲a∨国产av综合av| 日韩亚洲国产综合高清| 亚洲a∨无码国产精品久久网| 无码aⅴ精品一区二区三区| 国产欧美日韩精品a在线观看| 影音先锋在线亚洲网站| 香蕉啪视频在线观看视频久| 亚洲国产日韩a在线播放| 影音先锋亚洲成aⅴ人在| 狠狠色综合网久久久久久| 日韩国产亚洲欧美中国v| 最新国产成人无码久久| 国产欧美一区二区精品久久久| 亚洲 中文 欧美 日韩 在线| 国产精品尹人在线观看| 校花高潮抽搐冒白浆| av无码一区二区三区| 337p西西人体大胆瓣开下部| 成人亚洲欧美久久久久| 在线天堂资源www| 国产成人精品123区免费视频| 国内精品卡一卡二卡三| 东北老女人高潮大喊舒服死了| 午夜羞羞影院男女爽爽爽| 中文字幕乱妇无码av在线| 亚洲综合在线视频自拍| 亚洲 熟女 久久 国产| 国产精品va无码一区二区| 日本熟妇人妻xxxxx| 欧洲亚洲国产成人综合色婷婷| 国产尤物精品自在拍视频首页| 天天躁夜夜躁狠狠眼泪| 老司机深夜18禁污污网站|