Recombinant Mouse C-C motif chemokine 6 protein (Ccl6)

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中文名稱：

Recombinant Mouse C-C motif chemokine 6 protein(Ccl6) (Active)
貨號：

CSB-AP001251MO
規格：

￥2124
圖片：
其他：

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產品詳情

純度：

>97% as determined by SDS-PAGE.
內毒素：

Less than 1.0 EU/μg as determined by LAL method.
生物活性：

Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human CCR1 transfected murine BaF3 cells is in a concentration range of 10-100 ng/ml.
基因名：

Ccl6
Uniprot No.：

P27784
別名：

Ccl6; C10; Scya6C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6) [Cleaved into: CCL6(22-95); CCL6(23-95)]
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.Coli
分子量：

10.7 kDa
表達區域：

22-116aa
氨基酸序列

GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA
蛋白標簽：

Tag-Free
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, pH 8.0, 500 mM NaCl
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

5-10 business days
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
基因功能參考文獻：
1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
2. enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID: 19812544
3. the injury-induced expression of C10 at the mRNA and protein level PMID: 11895334
4. c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID: 12356575
5. CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID: 17234680
6. the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID: 19171873
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亞細胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
組織特異性：

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
數據庫鏈接：

KEGG: mmu:20305

STRING: 10090.ENSMUSP00000019071

UniGene: Mm.137